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Objective To explore the potential of salivary gland biopsy supernatants (the secretome) as a novel tool to aid in stratification of patients with sicca syndrome and to study local immunopathology in Sjögren’s syndrome.Methods Labial salivary glan

Externí odkaz: https://doaj.org/article/539dc20a783e49bdbfa5902bff2301dc

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Hyperresponsive cytosolic DNA-sensing pathway in monocytes from primary Sjögren’s syndrome

Autor: Erika Huijser, Iris L A Bodewes, Mirthe S Lourens, Cornelia G van Helden-Meeuwsen, Thierry P P van den Bosch, Dwin G B Grashof, Harmen J G van de Werken, Ana P Lopes, Joel A G van Roon, Paul L A van Daele, Zana Brkic, Willem A Dik, Marjan A Versnel

Publikováno v: Rheumatology (Oxford, England), 61(8), 3491-3496. Oxford University Press

Objectives Cytosolic DNA-sensing pathway stimulation prompts type I IFN (IFN-I) production, but its role in systemic IFN-I pathway activation in primary SS (pSS) is poorly studied. Here we investigate the responsiveness of pSS monocytes and plasmacyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbf012e6d8a391514da3e9bf2dc51a2
https://doi.org/10.1093/rheumatology/keac016

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In patients with primary Sjögren’s syndrome innate-like MAIT cells display upregulated IL-7R, IFN-γ, and IL-21 expression and have increased proportions of CCR9 and CXCR5-expressing cells

Autor: Anneline C, Hinrichs, Aike A, Kruize, Helen L, Leavis, Joel A G, van Roon

Publikováno v: Frontiers in Immunology. 13

IntroductionMucosal-associated invariant T (MAIT) cells might play a role in B cell hyperactivity and local inflammation in primary Sjögren’s syndrome (pSS), just like previously studied mucosa-associated CCR9+ and CXCR5+ T helper cells. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb15307902ebaa3d9d7300acadec900
https://doi.org/10.3389/fimmu.2022.1017157

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Trained Immunity in Primary Sjögren’s Syndrome

Autor: Erika, Huijser, Cornelia G, van Helden-Meeuwsen, Dwin G B, Grashof, Jessica R, Tarn, Zana, Brkic, Josje M A, Huisman, M Javad, Wahadat, Harmen J G, van de Werken, Ana P, Lopes, Joel A G, van Roon, Paul L A, van Daele, Sylvia, Kamphuis, Wan-Fai, Ng, Siroon, Bekkering, Leo A B, Joosten, Willem A, Dik, Marjan A, Versnel

Publikováno v: Frontiers in Immunology, 13
Frontiers in Immunology, 13:840751. Frontiers Media S.A.

BackgroundTrained immunity – or innate immune memory – can be described as the long-term reprogramming of innate immune cells towards a hyperresponsive state which involves intracellular metabolic changes. Trained immunity has been linked to athe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d26bbcee5f400b935c494c750247071
https://doi.org/10.3389/fimmu.2022.840751

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CCL5 Release by CCR9+ CD8 T Cells: A Potential Contributor to Immunopathology of Primary Sjögren’s Syndrome

Autor: Anneline C, Hinrichs, Sofie L M, Blokland, Aike A, Kruize, Floris P J, Lafeber, Helen L, Leavis, Joel A G, van Roon

Publikováno v: Frontiers in Immunology. 13

IntroductionIncreased CCL5 expression and CD8 T cells have been shown to be pivotal regulators of immunopathology in primary Sjögren’s syndrome (pSS) and pSS-like disease. Increased CCL5 expression by CCR9+ CD4 T cells has previously been implicat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d546d17172a223ee32b8062f8fd72a
https://doi.org/10.3389/fimmu.2022.887972

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