Immune-based biomarker accurately predicts response to imiquimod immunotherapy in cervical high-grade squamous intraepithelial lesions

Autor: Natasja Hendriks, Sjoerd H van der Burg, Ziena Abdulrahman, Noel F C C de Miranda, Edith M G van Esch, Peggy J de Vos van Steenwijk, Antonios Somarakis, Arnold J Kruse, Anna J M van de Sande, Heleen J van Beekhuizen, Jurgen M J Piek, Loes F S Kooreman, Brigitte F M Slangen

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 11 (2022)

Background The complete response rate of cervical high-grade squamous intraepithelial lesion (cHSIL) patients to imiquimod immunotherapy is approximately 60%. Consequently, many patients are exposed to unnecessary adverse effects of imiquimod. On the

Externí odkaz: https://doaj.org/article/ae2985823b1043c281f9a4695715eadb

Immune-based biomarker accurately predicts response to imiquimod immunotherapy in cervical high-grade squamous intraepithelial lesions

Autor: Ziena Abdulrahman, Natasja Hendriks, Arnold J Kruse, Antonios Somarakis, Anna J M van de Sande, Heleen J van Beekhuizen, Jurgen M J Piek, Noel F C C de Miranda, Loes F S Kooreman, Brigitte F M Slangen, Sjoerd H van der Burg, Peggy J de Vos van Steenwijk, Edith M G van Esch

Publikováno v: Journal for ImmunoTherapy of Cancer, 10(11). BMJ PUBLISHING GROUP
Journal for ImmunoTherapy of Cancer, 10(11):e005288. BioMed Central Ltd
Journal for ImmunoTherapy of Cancer, 10(11):e005288. BioMed Central Ltd.

BackgroundThe complete response rate of cervical high-grade squamous intraepithelial lesion (cHSIL) patients to imiquimod immunotherapy is approximately 60%. Consequently, many patients are exposed to unnecessary adverse effects of imiquimod. On the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa6784953e399ce85d2a805a4a355de
https://doi.org/10.1136/jitc-2022-005288

Importance of the Immune Microenvironment in the Spontaneous Regression of Cervical Squamous Intraepithelial Lesions (cSIL) and Implications for Immunotherapy

Autor: Caroline L. P. Muntinga, Peggy J. de Vos van Steenwijk, Ruud L. M. Bekkers, Edith M. G. van Esch

Publikováno v: Journal of Clinical Medicine, 11(5):1432. Multidisciplinary Digital Publishing Institute (MDPI)

Cervical high-grade squamous intraepithelial lesions (cHSILs) develop as a result of a persistent high-risk human papilloma virus (hrHPV) infection. The natural course of cHSIL is hard to predict, depending on a multitude of viral, clinical, and immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08665e986d32ab7dac2fed879614cd93
https://doi.org/10.3390/jcm11051432

Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell Response

Autor: J Hanneke N G Oude Elberink, Marij J. P. Welters, Marjolein J. Kagie, Nikki M. Loof, Theo Stijnen, Linda F. M. Stynenbosch, Bart W. J. Hellebrekers, Marc van Beurden, Margriet J. G. Löwik, A. Rob P. M. Valentijn, Ineke E. Hamming, Sjoerd H. van der Burg, Tjalling Bosse, Henk W.R. Schreuder, Dorien M A Berends-van der Meer, Hans W. Nijman, Mariëtte I.E. van Poelgeest, Edith M G van Esch, Renee Vermeij, Gert Jan Fleuren, Toos Daemen, J. Baptist Trimbos, Cornelis J. M. Melief, Harry Hollema, Lorraine M. Fathers, Gemma G. Kenter, Jaap Oostendorp

Publikováno v: Clinical cancer research, 22(10), 2342-2350. American Association for Cancer Research Inc.
Clinical Cancer Research, 22(10), 2342-2350. AMER ASSOC CANCER RESEARCH
van Poelgeest, M I E, Welters, M J P, Vermeij, R, Stynenbosch, L F M, Loof, N M, Berends-van der Meer, D M A, Lowik, M J G, Hamming, I L E, van Esch, E M G, Hellebrekers, B W J, van Beurden, M, Schreuder, H W, Kagie, M J, Trimbos, J B M Z, Fathers, L M, Daemen, T, Hollema, H, Valentijn, A R P M, Oostendorp, J, Oude Elberink, H N G, Fleuren, G J, Bosse, T, Kenter, G G, Stijnen, T, Nijman, H W, Melief, C J M & van der Burg, S H 2016, ' Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell Response ', Clinical Cancer Research, vol. 22, no. 10, pp. 2342-2350 . https://doi.org/10.1158/1078-0432.CCR-15-2594
Clinical Cancer Research, 22(10), 2342. American Association for Cancer Research Inc.
Clinical Cancer Research, 22(10), 2342-2350. American Association for Cancer Research Inc.

Purpose: Therapeutic vaccination with human papillomavirus type 16 (HPV16) E6 and E7 synthetic long peptides (SLP) is effective against HPV16-induced high-grade vulvar and vaginal intraepithelial neoplasia (VIN/VaIN). However, clinical nonresponders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0019df04b3e776a79539df40f209528
https://doi.org/10.1158/1078-0432.ccr-15-2594

The diagnostic and therapeutic approach of a primary bilateral leiomyoma of the ovaries: a case report and a literature review

Autor: Maddy J. G. H. Smeets, E. M. G. van Esch, H. E. Schaafsma, S. E. van Wijngaarden, Johann P. T. Rhemrev

Publikováno v: Archives of Gynecology and Obstetrics, 283, 1369-71
Archives of Gynecology and Obstetrics, 283, 6, pp. 1369-71

Item does not contain fulltext INTRODUCTION: A primary fibroid (leiomyoma) arising from both ovaries is rare and can be difficult to diagnose as a result of the low incidence and its indistinctive presentation. A literature review on the diagnostic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc1e0294df64be10f2170b0412e5ef6
https://doi.org/10.1007/s00404-010-1576-0