Zobrazeno 1 - 10
of 291
pro vyhledávání: '"G. de Geest"'
Autor:
Sonia Jangra, Alexander Lamoot, Gagandeep Singh, Gabriel Laghlali, Yong Chen, Tingting Ye, Adolfo García-Sastre, Bruno G. De Geest, Michael Schotsaert
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
There are considerable avenues through which currently licensed influenza vaccines could be optimized. We tested influenza vaccination in a mouse model with two adjuvants: Sendai virus-derived defective interfering (SDI) RNA, a RIG-I agonist; and an
Externí odkaz:
https://doaj.org/article/ec458a7862724502a5cded87814e573f
Autor:
Elly De Vlieghere, Koen Van de Vijver, Eva Blondeel, Nathan Carpentier, Rouba Ghobeira, Jarne Pauwels, Sebastian Riemann, Manon Minsart, Charlotte Fieuws, Johanna Mestach, Ans Baeyens, Nathalie De Geyter, Charlotte Debbaut, Hannelore Denys, Benedicte Descamps, Kathleen Claes, Anne Vral, Jo Van Dorpe, Kris Gevaert, Bruno G. De Geest, Wim Ceelen, Sandra Van Vlierberghe, Olivier De Wever
Publikováno v:
Biomaterials Research, Vol 27, Iss 1, Pp 1-18 (2023)
Abstract Background Long-term drug evaluation heavily relies upon rodent models. Drug discovery methods to reduce animal models in oncology may include three-dimensional (3D) cellular systems that take into account tumor microenvironment (TME) cell t
Externí odkaz:
https://doaj.org/article/3e5a307685aa4c44b056bfedd46942cf
Publikováno v:
Bioactive Materials, Vol 24, Iss , Pp 524-534 (2023)
Zwitterionic polymers are known to interact with cells and have been shown to reveal cancer cell specificity. In this work, the importance of the chemistry of the polymer backbone for the cellular specificity of amino-acid-derived polyzwitterions is
Externí odkaz:
https://doaj.org/article/984a404ccac145739fb6fdadb6eb662d
Autor:
Lauren A. Chang, Angela Choi, Raveen Rathnasinghe, Prajakta Warang, Moataz Noureddine, Sonia Jangra, Yong Chen, Bruno G. De Geest, Michael Schotsaert
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Eosinophils are important mediators of mucosal tissue homeostasis, anti-helminth responses, and allergy. Lung eosinophilia has previously been linked to aberrant Type 2-skewed T cell responses to respiratory viral infection and may also be a conseque
Externí odkaz:
https://doaj.org/article/f7543b749d5d433c9261b41937fc7018
Autor:
Raveen Rathnasinghe, Sonia Jangra, Chengjin Ye, Anastasija Cupic, Gagandeep Singh, Carles Martínez-Romero, Lubbertus C. F. Mulder, Thomas Kehrer, Soner Yildiz, Angela Choi, Stephen T. Yeung, Ignacio Mena, Virginia Gillespie, Jana De Vrieze, Sadaf Aslam, Daniel Stadlbauer, David A. Meekins, Chester D. McDowell, Velmurugan Balaraman, Michael J. Corley, Juergen A. Richt, Bruno G. De Geest, Lisa Miorin, PVI study group, Florian Krammer, Luis Martinez-Sobrido, Viviana Simon, Adolfo García-Sastre, Michael Schotsaert
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Here, Rathnasinghe et al. characterize the pathogenesis of a mouse-adapted SARS-CoV-2 in infected obese and aged mice, and identify mutations that are present in SARS-CoV-2 variants of concern, associated with higher transmissibility.
Externí odkaz:
https://doaj.org/article/12c6e893f2b043239df7246c95215cf6
Autor:
Sonia Jangra, Gabriel Laghlali, Angela Choi, Raveen Rathnasinghe, Yong Chen, Soner Yildiz, Lynda Coughlan, Adolfo García-Sastre, Bruno G. De Geest, Michael Schotsaert
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Influenza vaccine effectiveness could be improved by combination with an adjuvant with the potential to enhance the host-vaccine response both quantitatively and qualitatively. The goal of this study was to explore a RIG-I agonist (SDI-nanogel) and a
Externí odkaz:
https://doaj.org/article/8948680f21d34497a5a69b874b6560f4
Autor:
S. Saravanan, Anashwara Babu, Ronald Merckx, Zifu Zhong, Mageshwari Anandan, Venkatramaiah Nutalapati, Bruno G. De Geest, Richard Hoogenboom, Valentin Victor Jerca, Samarendra Maji
Publikováno v:
Materials Chemistry Frontiers. 7:1875-1885
Oligo(ethylene glycol) methacrylates functionalized with anthrapyrazolone are reported as fluorescent polymeric thermometers with a broad linear temperature sensing regime.
Publikováno v:
Polymer Chemistry. 14:2034-2044
We present the synthesis of different amine-functionalised poly(2-oxazoline)s, their dual pH and temperature response as well as their capability to as promising stimuli responsive drug delivery vectors.
Autor:
Eamy Nursaliza Yaacob, Parisa Norouzitallab, Bruno G. De Geest, Aline Bajek, Kristof Dierckens, Peter Bossier, Daisy Vanrompay
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Vibrio anguillarum causes high mortality in European sea bass (Dicentrarchus labrax) larviculture and is a hindering factor for successful sustainable aquaculture of this commercially valuable species. Priming of the innate immune system through admi
Externí odkaz:
https://doaj.org/article/0b489d768fb541a0b51f0ee0adee3927
Autor:
Victor Bosteels, Sandra Maréchal, Clint De Nolf, Sofie Rennen, Jonathan Maelfait, Simon J. Tavernier, Jessica Vetters, Evelien Van De Velde, Farzaneh Fayazpour, Kim Deswarte, Alexander Lamoot, Julie Van Duyse, Liesbet Martens, Cédric Bosteels, Ria Roelandt, Annelies Emmaneel, Sofie Van Gassen, Louis Boon, Gert Van Isterdael, Isabelle Guillas, Niels Vandamme, Doris Höglinger, Bruno G. De Geest, Wilfried Le Goff, Yvan Saeys, Kodi S. Ravichandran, Bart N. Lambrecht, Sophie Janssens
Publikováno v:
Science immunology, 8(83):eadd3955. American Association for the Advancement of Science
Dendritic cells (DCs) mature in an immunogenic or tolerogenic manner depending on the context in which an antigen is perceived, preserving the balance between immunity and tolerance. Whereas the pathways driving immunogenic maturation in response to