Zobrazeno 1 - 10
of 215
pro vyhledávání: '"G. William Rebeck"'
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-17 (2024)
Abstract Microglia are highly dynamic cells that play a critical role in tissue homeostasis through the surveillance of brain parenchyma and response to cues associated with damage. Aging and APOE4 genotype are the strongest risk factors for Alzheime
Externí odkaz:
https://doaj.org/article/7936248805824daca77f40ec975cc4d4
Autor:
Griffin A. Greco, Mitchell Rock, Matthew Amontree, Maria Fe Lanfranco, Holly Korthas, Sung Hyeok Hong, R. Scott Turner, G. William Rebeck, Katherine Conant
Publikováno v:
Neurobiology of Disease, Vol 179, Iss , Pp 106057- (2023)
The APOE4 allele increases the risk for Alzheimer's disease (AD) in a dose-dependent manner and is also associated with cognitive decline in non-demented elderly controls. In mice with targeted gene replacement (TR) of murine APOE with human APOE3 or
Externí odkaz:
https://doaj.org/article/fd4b70330d404358b61b5d8721a3fd22
Autor:
Elena Galvano, Harshul Pandit, Jordy Sepulveda, Christi Anne S. Ng, Melanie K. Becher, Jeanne S. Mandelblatt, Kathleen Van Dyk, G. William Rebeck
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionTamoxifen is a common treatment for estrogen receptor-positive breast cancer. While tamoxifen treatment is generally accepted as safe, there are concerns about adverse effects on cognition.MethodsWe used a mouse model of chronic tamoxifen
Externí odkaz:
https://doaj.org/article/0caf651bc3014370b5cc81bca03cb233
Autor:
Christi Anne S. Ng, Lucas P. Biran, Elena Galvano, Jeanne Mandelblatt, Stefano Vicini, G. William Rebeck
Publikováno v:
Neurobiology of Disease, Vol 175, Iss , Pp 105915- (2022)
Many cancer survivors experience cancer-related cognitive impairment (CRCI), which is characterized by problems of attention, working memory, and executive function following chemotherapy and/or hormonal treatment. APOE4, the strongest genetic risk f
Externí odkaz:
https://doaj.org/article/0a4103d8ac614419bf60644ba43db267
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021)
Abstract Background APOE 4 is the strongest genetic risk factor for Alzheimer’s disease (AD), and obesity is a strong environmental risk factor for AD. These factors result in multiple central nervous system (CNS) disturbances and significantly inc
Externí odkaz:
https://doaj.org/article/8ea9e138801e4b9a957c50f4e333d0f8
Autor:
Sarah A. Flowers, G. William Rebeck
Publikováno v:
Neurobiology of Disease, Vol 136, Iss , Pp 104724- (2020)
The APOE4 protein affects the primary neuropathological markers of Alzheimer's disease (AD): amyloid plaques, neurofibrillary tangles, and gliosis. These interactions have been investigated to understand the strong effect of APOE genotype on risk of
Externí odkaz:
https://doaj.org/article/cbd468a3a1634b8b93bbcfd21a28e170
Autor:
G. William Rebeck
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 8, Pp 1493-1499 (2017)
The role of APOE in the risk of Alzheimer's disease (AD) has largely focused on its effects on AD pathological processes. However, there are increasing data that APOE genotype affects processes in normal brains. Studies of young cognitively normal hu
Externí odkaz:
https://doaj.org/article/e8352060605b4269bd4cf52ed9d72047
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6336 (2020)
Apolipoprotein E (APOE) is the major cholesterol carrier in the brain, affecting various normal cellular processes including neuronal growth, repair and remodeling of membranes, synaptogenesis, clearance and degradation of amyloid β (Aβ) and neuroi
Externí odkaz:
https://doaj.org/article/c6b79fe1aed64983b39ba7288f6a5f84
Autor:
Tamar Demby, G. William Rebeck, Christopher Albanese, Olga C. Rodriguez, Yichien Lee, Jeanne Mandelblatt
Publikováno v:
Journal of Clinical and Translational Science, Vol 3, Pp 1-1 (2019)
OBJECTIVES/SPECIFIC AIMS: Chemotherapy-related cognitive impairment (CRCI) affects 15-35% of breast cancer survivors and constitutes a significant challenge for survivor quality of life. Among older breast cancer survivors who received chemotherapy t
Externí odkaz:
https://doaj.org/article/847b5aec1e9a4ce599908fe13f2c0945
Autor:
Nahdia S. Jones, G. William Rebeck
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 1, p 63 (2018)
The APOE gene has three common alleles—E2, E3, and E4, with APOE4 being the strongest genetic risk factor for developing Alzheimer’s Disease (AD). Obesity is a global epidemic and contributes to multiple metabolic problems. Obesity is also a risk
Externí odkaz:
https://doaj.org/article/b5ce4d23de7142ea964f0cb144310d56