Zobrazeno 1 - 10
of 76
pro vyhledávání: '"G. Willemsens"'
Autor:
Gerard Charles Sanz, B Janssen, J. Van Dun, L Dillen, C. Van Hove, Walter Wouters, J Van heusden, P Moelans, H Bruwiere, R Van Ginckel, G Willemsens, B.-J. Van Der Leede, Wim Floren, Michel Janicot, Marc Venet
Publikováno v:
British Journal of Cancer
All-trans-retinoic acid is a potent inhibitor of cell proliferation and inducer of differentiation. However, the clinical use of all-trans-retinoic acid in the treatment of cancer is significantly hampered by its toxicity and the prompt emergence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b534dd2944d23dbc3395a820b97d63
http://europepmc.org/articles/PMC2375285
http://europepmc.org/articles/PMC2375285
Publikováno v:
Biochemical Pharmacology. 43:739-744
Ridogrel [(E)-5-[[[(3-pyridinyl)[3-(trifluoromethyl)phenyl] methylene]amino]oxy] pentanoic acid] is a potent inhibitor of the P450-dependent human platelet thromboxane A2 (TxA2) synthase. Fifty percent inhibition is already achieved at 5.0 +/- 0.37 n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0aac11d548645f52752dc8fef420e56
https://doi.org/10.1016/0006-2952(92)90238-e
https://doi.org/10.1016/0006-2952(92)90238-e
Autor:
I. Roels, Patrick Marichal, H. Vanden Bossche, D. Bellens, L. Le Jeune, M.-C. Coene, P. A. J. Janssen, G. Willemsens, J. Gorrens
Publikováno v:
Mycoses. 33:335-352
The N-1-substituted triazole antifungal, saperconazole, is a potent inhibitor of ergosterol synthesis in Candida albicans, Aspergillus fumigatus and Trichophyton mentagrophytes. Fifty % inhibition is already achieved at nanomolar concentrations. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3a221eb9c4cefd8fd0a62f986d493a
https://doi.org/10.1111/myc.1990.33.7-8.335
https://doi.org/10.1111/myc.1990.33.7-8.335
Publikováno v:
Biochemical Society Transactions. 18:10-13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19d6062f0e2da01828b1857bac4cced
https://doi.org/10.1042/bst0180010
https://doi.org/10.1042/bst0180010
Autor:
A. Raeymaekers, G. Vanden Bussche, Gerard Charles Sanz, E. Snoeck, R. De Coster, J. Bruynseels, W. Wouters, H. Vanden Bossche, M.-C. Coene, P. Van Rooy, G. Willemsens, Eddy Jean Edgard Freyne, P. A. J. Janssen
Publikováno v:
The Prostate. 16:345-357
R 75251, a new imidazole derivative, inhibited the conversion of androgens to estrogens, of progestins to androstenedione and testosterone, and of 11-deoxycorticosterone to corticosterone in human placenta microsomes, subcellular fraction of rat test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30ace7e98bb9f93cd53d728f40bbbaa
https://doi.org/10.1002/pros.2990160409
https://doi.org/10.1002/pros.2990160409
Autor:
P, Stoppie, M, Borgers, P, Borghgraef, L, Dillen, J, Goossens, G, Sanz, H, Szel, C, Van Hove, G, Van Nyen, G, Nobels, H, Vanden Bossche, M, Venet, G, Willemsens, J, Van Wauwe
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 293(1)
All-trans-retinoic acid (RA) regulates epithelial differentiation and growth through activation of specific nuclear RA receptors (RARs). Because high-rate metabolism largely impairs the biological efficacy of RA, we have sought for compounds capable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f9723d4893415e86456a49638d62381
https://pubmed.ncbi.nlm.nih.gov/10734183
https://pubmed.ncbi.nlm.nih.gov/10734183
Autor:
W. Cools, G. Willemsens, L. Le Jeune, Patrick Marichal, Hugo Verhoeven, H. Vanden Bossche, M-C. Coene
Publikováno v:
ACS Symposium Series ISBN: 9780841224575
Regulation of Isopentenoid Metabolism
Regulation of Isopentenoid Metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0abd76f4c64e1c13bce3e55a45c01464
https://doi.org/10.1021/bk-1992-0497.ch016
https://doi.org/10.1021/bk-1992-0497.ch016
Publikováno v:
Journal of Basic and Clinical Physiology and Pharmacology. 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8add2d43fb81863253f39cc7683134d
https://doi.org/10.1515/jbcpp.1992.3.s1.93
https://doi.org/10.1515/jbcpp.1992.3.s1.93
Publikováno v:
Medical Mycology. 13:63-73
The growth of Candida albicans was studied in control cultures and in the presence of miconazole or clotrimazole. Each drug prolonged the lag phase and reduced the total final population. Although miconazole, at the low concentrations used, was a les
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02e31658d671ce581a7367046759128b
https://doi.org/10.1080/00362177585190131
https://doi.org/10.1080/00362177585190131
Autor:
Hugo Verhoeven, M.-C. Coene, Patrick Marichal, J. Gorrens, Ludo Le Jeune, W. Lauwers, Dany Bellens, G. Willemsens, Roland De Coster, D. Beerens, W. Cools, Christian Haelterman, Hugo Vanden Bossche
Publikováno v:
Drug Development Research. 8:287-298
The N-substituted triazole, itraconazole, has high affinity for the cytochrome P-450 (cyt. P-450) isozyme involved in the 14α-demethylation of lanosterol in Candida albicans microsomes. Fifty per cent inhibition was already observed at itraconazole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c0932eac405495d8af19d15bc00b7cd
https://doi.org/10.1002/ddr.430080133
https://doi.org/10.1002/ddr.430080133