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IL-4 alone and in combination with IL-10 protects against blood-induced cartilage damage

Autor: J.A. van Roon, F.P.J.G. Lafeber, N.W. Jansen, M.E. van Meegeren, M. J. G. Wenting, A.C.W. van Wesel, G. Roosendaal

Publikováno v: Osteoarthritis and Cartilage. 20:764-772

SummaryObjectiveIt has been reported that interleukin (IL)-10 limits blood-induced cartilage damage. Our aim was to study the effect of IL-4 alone and in combination with IL-10 on blood-induced cartilage damage.DesignHealthy human full thickness cart

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa7d90798f724e9cc5d4171a350b02f
https://doi.org/10.1016/j.joca.2012.04.002

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Akademický článek

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Salivary gland and peripheral blood T helper 1 and 2 cell activity in Sjogren's syndrome compared with non-Sjogren's sicca syndrome

Autor: E Knol, I C Bihari, J. W. J. Bijlsma, F.P.J.G. Lafeber, J M van Woerkom, Aike A. Kruize, M J G Wenting van Wijk, J. W. G. Jacobs, J.A. van Roon

Publikováno v: Annals of the Rheumatic Diseases. 64:1474-1479

Objectives: To investigate whether differences in T helper (Th) 1 and Th2 cell activity in salivary glands ("local") or ("peripheral") blood can discriminate between Sjogren's syndrome (SS) and non-Sjogren's sicca syndrome (nSS-sicca). Additionally,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae15ef6f49154fe4e2aaac1cfa34ddc
https://doi.org/10.1136/ard.2004.031781

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Short-Term Exposure of Cartilage to Blood Results in Chondrocyte Apoptosis

Autor: M. J. G. Wenting, Johannes W. J. Bijlsma, Michel J. J. Hooiveld, Floris P J G Lafeber, Marijke van den Berg, Goris Roosendaal

Publikováno v: The American Journal of Pathology. 162:943-951

Studies have shown that joint bleeding leads to cartilage degradation independent of concurrent synovitis. We hypothesized that the blood-induced cartilage damage is because of increased chondrocyte apoptosis after short-term exposure of whole blood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b892b9059af8d3f9f827c17c39319b
https://doi.org/10.1016/s0002-9440(10)63889-8

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Iron deposits and catabolic properties of synovial tissue from patients with haemophilia

Autor: G. Roosendaal, M. E. Vianen, M. J. G. Wenting, A. C. van Rinsum, H. M. van den Berg, F. P. J. G. Lafeber, J. W. J. Bijlsma

Publikováno v: The Journal of Bone and Joint Surgery. British volume. :540-545

Haemophilic arthropathy is characterised by iron deposits in synovial tissues. We investigated the suggestion that iron plays an important role in synovial changes. We obtained synovial tissue from six patients with haemophilia during arthroplasty, f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30f742c5c652594083fd7f161251bcfc
https://doi.org/10.1302/0301-620x.80b3.0800540

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Identification and expression of iron regulators in human synovium: evidence for upregulation in haemophilic arthropathy compared to rheumatoid arthritis, osteoarthritis, and healthy controls

Autor: B. S. Van Asbeck, Roger E. G. Schutgens, K. van Veghel, Floris P J G Lafeber, Goris Roosendaal, M. J. G. Wenting, Douwe H. Biesma, Laurens Nieuwenhuizen

Publikováno v: Haemophilia : the official journal of the World Federation of Hemophilia. 19(4)

Recurrent joint bleeding is the most common manifestation of severe haemophilia resulting in haemophilic arthropathy (HA). Iron plays a central role in the pathogenesis of the two main features of HA: synovitis and cartilage destruction. The aim of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022a2552a459bc50966b52d4fa9e45e3
https://pubmed.ncbi.nlm.nih.gov/23777533

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Increased interleukin (IL)-7R alpha expression in salivary glands of patients with primary Sjogren's syndrome is restricted to T cells and correlates with IL-7 expression, lymphocyte numbers and activity

Autor: Aike A. Kruize, A. Bikker, J. W. J. Bijlsma, M. J. G. Wenting, Marjan A. Versnel, F.P.J.G. Lafeber, J.A. van Roon

Publikováno v: Annals of the Rheumatic Diseases, 71(6), 1027-1033. BMJ Publishing Group

Objective: To identify interleukin (IL)-7Rα expression in the labial salivary gland (LSG) of patients with primary Sjogren's syndrome (pSS) and non-Sjogren's syndrome sicca (nSS-sicca) and to study its correlation with glandular infl ammation and IL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d38dea69d284a750374ee107cc4cb39
https://pure.eur.nl/en/publications/cc3f497a-57e6-435f-8b22-cc87e8704e29

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Intra-articular glucocorticoid injections decrease the number of steroid hormone receptor positive cells in synovial tissue of patients with persistent knee arthritis

Autor: Z. N. Jahangier, Johannes W. J. Bijlsma, Silvia Capellino, Floris P J G Lafeber, Marlies C van der Goes, Rainer H. Straub, Johannes W G Jacobs, M. J. G. Wenting, Luise Rauch

Objectives: To explore changes in the number of steroid hormone receptor positive cells in synovial tissue (ST) after intra-articular glucocorticoid injection, to correlate these changes with changes in clinical variables, and to evaluate whether the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16db9f59a0d6aa3706e95f0aa8ae9a95

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