Zobrazeno 1 - 10
of 21
pro vyhledávání: '"G. Wei Xu"'
Autor:
G Wei Xu, Julia I Toth, Sara R da Silva, Stacey-Lynn Paiva, Julie L Lukkarila, Rose Hurren, Neil Maclean, Mahadeo A Sukhai, Rabindra N Bhattacharjee, Carolyn A Goard, Bruno Medeiros, Patrick T Gunning, Sirano Dhe-Paganon, Matthew D Petroski, Aaron D Schimmer
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93530 (2014)
The NEDD8-activating enzyme (NAE) initiates neddylation, the cascade of post-translational NEDD8 conjugation onto target proteins. MLN4924, a selective NAE inhibitor, has displayed preclinical anti-tumor activity in vitro and in vivo, and promising c
Externí odkaz:
https://doaj.org/article/c25a0099eda545d9907d3b27a9070b27
Autor:
Neil MacLean, Shawn Brennan, Adam C. Smith, Rose Hurren, Allison Berger, Xiaoming Wang, Razq Hakem, Marcela Gronda, Mark D. Minden, Sara Farshchi Zarabi, Simon Kavanagh, Tary Traore, G. Wei Xu, Aaron D. Schimmer, Emil F. Pai, Samir H. Barghout, Ondrej Halgas, Michael Milhollen, Marc L. Hyer, Parasvi S. Patel, Danny V. Jeyaraju
Publikováno v:
Leukemia. 33:37-51
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy for which new therapeutic approaches are required. One such potential therapeutic strategy is to target the ubiquitin-like modifier-activating enzyme 1 (UBA1), the initiating enzyme
Autor:
Mathieu Lupien, Yulia Jitkova, Michael Mullokandov, Helen Loo Yau, Rima Al-awar, James R. Hawley, Rose Hurren, Troy Ketela, S. Kim, Veronique Voisin, Neil MacLean, Daniel D. De Carvalho, Mark D. Minden, Geethu E. Thomas, Val A. Fajardo, Ahmed Aman, Zhenyue Hao, Zaza Khuchua, G. Wei Xu, Gary D. Bader, Richard P. Bazinet, Juan J. Aristizabal Henao, Mingjing Xu, Paul J. LeBlanc, Ayesh K. Seneviratne, Steven M. Claypool, Steven M. Chan, Xiaoming Wang, Atan Gross, Aaron D. Schimmer, Ken D. Stark, David Sharon, Raphaël Chouinard-Watkins, Danny V. Jeyaraju, Caitlin Schafer, Marcela Gronda
Summary Tafazzin (TAZ) is a mitochondrial transacylase that remodels the mitochondrial cardiolipin into its mature form. Through a CRISPR screen, we identified TAZ as necessary for the growth and viability of acute myeloid leukemia (AML) cells. Genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b74e60e809d7c98db8697836fef410
https://europepmc.org/articles/PMC7137093/
https://europepmc.org/articles/PMC7137093/
Autor:
Gary D. Bader, Troy Ketela, Veronique Voisin, Danny V. Jeyaraju, Dilshad H. Khan, G. Wei Xu, Sajid A. Marhon, Yulia Jitkova, Michael Mullokandov, Rob C. Laister, Aaron D. Schimmer, Xiaoming Wang, Rose Hurren, Daniel D. De Carvalho, Marcela Gronda, Ayesh K. Seneviratne, Zachary Blatman, Neil MacLean, Mark D. Minden, Atan Gross, Yan Wu
Publikováno v:
Blood. 136(1)
Through a clustered regularly insterspaced short palindromic repeats (CRISPR) screen to identify mitochondrial genes necessary for the growth of acute myeloid leukemia (AML) cells, we identified the mitochondrial outer membrane protein mitochondrial
Autor:
Fieke W Hoff, Marcela Gronda, Jonathan St-Germain, Rose Hurren, G. Wei Xu, Changjiang Xu, Terzah M. Horton, Steven M. Kornblau, Yulia Jitkova, Xiaoming Wang, Andrea Arruda, Neil MacLean, Steven M. Chan, Sara Mirali, Boaz Nachmias, Yihua Qiu, David Sharon, Aaron D. Schimmer, Gary D. Bader, Veronique Voisin, Botham Aaron, Mark D. Minden, Brian Raught
Publikováno v:
Blood. 134:729-729
Acute myeloid leukemia (AML) cells and stem cells have unique mitochondrial characteristics with an increased reliance on oxidative phosphorylation (OXPHOS). To identify new biological vulnerabilities in the mitochondrial proteome of AML cells, we co
Autor:
Veronique Voisin, G. Wei Xu, Neil MacLean, Gary D. Bader, Rose Hurren, Ayesh K. Seneviratne, Aaron D. Schimmer, Boaz Nachmias, Xioaming Wang, Changjiang Xu, Liran I. Shlush
Publikováno v:
Blood. 134:2530-2530
Patients with relapsed AML (Acute Myeloid Leukemia) have a poor prognosis and few therapeutic options. Therefore, it remains critical to identify biological vulnerabilities in relapsed AML cells. To identify such vulnerabilities, we analyzed mRNA exp
Autor:
Barghout, Samir H, Parasvi S Patel, Xiaoming Wang, G Wei Xu, Kavanagh, Simon, Halgas, Ondrej, Zarabi, Sara F, Gronda, Marcela, Hurren, Rose, Jeyaraju, Danny V, Maclean, Neil, Hyer, Marc L, Berger, Allison, Tary Traore, Milhollen, Michael, Minden, Mark D, Pai, Emil F, Razq Hakem, Schimmer, Aaron D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0abee8e697ad2e4b5f92599500ed66b1
Autor:
Mingjing Xu, Ayesh Seneviratne, Val A. Fajardo, Geethu E. Thomas, G. Wei Xu, Rose Hurren, S. Kim, Neil MacLean, Xiaoming Wang, Marcela Gronda, Danny Jeyaraju, Yulia Jitkova, David Sharon, Ahmed Aman, Rima Al-awar, Steven Chan, Mark D. Minden, Paul LeBlanc, Aaron D. Schimmer
Publikováno v:
Cancer Research. 79:3003-3003
Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by the accumulation of malignant myeloid cells that have arrested maturation. Most therapeutic regimens approved or under development are cytotoxics. An alternate, but less expl
Autor:
Zachary Blatman, Rose Hurren, Aaron D. Schimmer, Geethu E. Thomas, Samir H. Barghout, Neil MacLean, G. Wei Xu
Publikováno v:
Blood. 132:1350-1350
UBA1 is the major ubiquitin-activating enzyme that initiates the ubiquitylation cascade whereby proteins are tagged with mono- or polyubiquitin to mark them for proteasomal degradation or modify their functions. Despite having equal levels of UBA1 pr
Autor:
Judd Berman, Vijay M. Shahani, Andrew Roughton, Mohsin Ali, Aaron D. Schimmer, Patrick T. Gunning, Julie L. Lukkarila, G. Wei Xu, Sirano Dhe-Paganon, Sara R. da Silva
Publikováno v:
ACS Medicinal Chemistry Letters. 2:577-582
MLN4924 is a selective inhibitor of the NEDD8-activating enzyme (NAE) and has advanced into clinical trials for the treatment of both solid and hematological malignancies. In contrast, the structurally similar compound 1 (developed by Millennium: The