Zobrazeno 1 - 10
of 16
pro vyhledávání: '"G. Webb McKnight"'
Autor:
G. Webb McKnight, Michael Dicay, Gary R. Martin, John L. Wallace, Jose G. Ferraz, Carla S. Coffin
Publikováno v:
Digestive and Liver Disease. 42:103-109
Hydrogen sulphide (H2S) exerts several anti-inflammatory effects, accelerates the healing of experimental gastric ulcers, and can stimulate intestinal secretion. Little is known about H2S synthesis in the gastrointestinal tract. The aim of this study
Publikováno v:
The FASEB Journal. 27
Publikováno v:
European Journal of Pharmacology. 239:171-176
Intestinal epithelial permeability can be modulated by the immune system and can be greatly increased by transepithelial migration of neutrophils. Since immunosuppressants have been reported to inhibit the ability of neutrophils to migrate, we assess
Autor:
G. Webb McKnight, John L. Wallace
Publikováno v:
Gastroenterology. 99:295-304
The ability of the "mucoid cap" of mucus, fibrin, and cellular debris that forms over sites of superficial gastric damage to provide a relatively high-pH microenvironment was investigated in the rat. Furthermore, the effects of administration of nons
Publikováno v:
European journal of pharmacology. 280(1)
Nitric oxide has been reported to have paradoxical effects in experimental endotoxic shock, contributing to the hemodynamic consequences of endotoxin administration, but apparently protecting the gastrointestinal mucosa. A novel class of nitric oxide
Publikováno v:
Gastroenterology. 105(5)
Background: Acute administration of prostaglandin E (PGE) may be cytoprotective for hepatocytes in acute hepatitis and for gastric mucosa in cirrhotic rats. We examined the effects of long-term PGE treatment on liver and stomach in cirrhotic rats. Me
Publikováno v:
Gastroenterology. 103(3)
Cirrhosis was induced in Sprague-Dawley rats via ligation of the common bile duct. Changes in gastric blood flow and mucosal architecture were examined. Using an ex vivo gastric chamber preparation, the susceptibility of the cirrhotic gastric mucosa
Publikováno v:
Inflammation. 16(4)
The role of neutrophils in the pathogenesis of acute colitis was investigated using a rabbit model. Colitis was induced by intracolonic administration of trinitrobenzene sulfonic acid in 30% ethanol. Myeloperoxidase activity was measured at various t
Publikováno v:
Gastroenterology. 100(4)
The role of leukocyte adherence in the mechanism of gastropathy induced by nonsteroidal antiinflammatory drugs was investigated using a rabbit model. Gastric damage was induced by intragastric instillation of indomethacin [5 mg/mL] for a period of 30
Autor:
Catherine M. Keenan, Nancy I.A. Byles, John L. Wallace, Wallace K. MacNaughton, G. Webb McKnight
Publikováno v:
Gastroenterology. 98(5 Pt 1)
The ability of various leukotrienes to alter the susceptibility of the rat gastric mucosa to injury by 20% ethanol and the possible mechanism of action were examined using an ex vivo gastric chamber preparation. Intraarterial infusions of leukotriene