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Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L

Autor: Milica Jevtic, Désirée Schatton, S. M. V. Kochan, S. Chandragiri, Elisa Motori, Hans-Georg Sprenger, Elena I. Rugarli, K. Ndoci, Patrick Giavalisco, Thomas Langer, S. Mueller, Vignesh Sakthivelu, G. Wani, J. M. Seeger, R. J. Acton, Matteo Bergami

The transition between quiescence and activation in neural stem and progenitor cells (NSPCs) is coupled to reversible changes in energy metabolism with key implications for life-long NSPC self-renewal and neurogenesis. How this metabolic plasticity i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68a156a3437704be32c14316655d12d1
https://doi.org/10.1101/2021.08.18.456709

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Vibration based detection of damage in fixed-fixed I-Beam using Particle Swarm Optimization

Autor: Sanjay W. Rukhande, Nitesh P. Yelve, Chirag G. Wani

Publikováno v: 2019 International Conference on Nascent Technologies in Engineering (ICNTE).

The service life of any structure must be smooth and safe. A breakdown period is start because of damages on the structure. In the literature, various studies are found which deal with the safety of structural beams. The risk of damage development is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dca74a2144beb880e19ddd1eff95bf79
https://doi.org/10.1109/icnte44896.2019.8945820

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Modulation of Ki67, p53 and RARbeta expression in normal, premalignant and malignant human oral epithelial cells by chemopreventive agents

Autor: S M, D'Ambrosio, R E, Gibson-D'Ambrosio, G, Wani, B, Casto, G E, Milo, G J, Kelloff, V E, Steele

Publikováno v: Anticancer research. 21(5)

Aberrant expression of Ki67, p53 and RARbeta are characteristic of many tumor types including those of the oral cavity. Chemopreventive agents may act by modulating their expression to more normal levels.The effects of 21 chemopreventive agents on th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2c7f28dfc4d33c8c6390fee826c37dc3
https://pubmed.ncbi.nlm.nih.gov/11848477

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Mdm2 mutant defective in binding p300 promotes ubiquitination but not degradation of p53: evidence for the role of p300 in integrating ubiquitination and proteolysis

Autor: Q, Zhu, J, Yao, G, Wani, M A, Wani, A A, Wani

Publikováno v: The Journal of biological chemistry. 276(32)

Turnover of the p53 tumor suppressor protein is mediated by Mdm2 through the ubiquitin proteolysis pathway. p300, a co-activator for p53, also participates in this process by complexing with Mdm2. We now report that the mutant Mdm2, defective in p53

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6adac4abaebc86341fb688df5b650928
https://pubmed.ncbi.nlm.nih.gov/11340074

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Human homologue of yeast Rad23 protein A interacts with p300/cyclic AMP-responsive element binding (CREB)-binding protein to down-regulate transcriptional activity of p53

Autor: Q, Zhu, G, Wani, M A, Wani, A A, Wani

Publikováno v: Cancer research. 61(1)

The tumor suppressor protein p53 regulates various cellular responses to DNA damage and plays a significant role in DNA repair. The nuclear p300/cyclic AMP-responsive element binding (CREB)-binding protein (CBP) proteins act as coactivators in suppor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a7b202e853e4a699ba2bbdb4f9296223
https://pubmed.ncbi.nlm.nih.gov/11196199

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Expression of the O6-alkylguanine-DNA alkyltransferase gene is elevated in human breast tumor cells

Autor: G, Wani, S M, D'Ambrosio

Publikováno v: Anticancer research. 17(6D)

In tumors, resistance to chemotherapeutic drugs that alkylate the O6 position of guanine correlates with the levels of the DNA repair protein, O6-alkylguanine DNA alkyltransferase (AGT). The expression of AGT gene in human breast tumors was evaluated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::545dc797c61d4514ee2e377f798c634b
https://pubmed.ncbi.nlm.nih.gov/9494526

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Expression of molecular biomarkers in primary breast tumors implanted into a surrogate host: increased levels of cyclins correlate with tumor progression

Autor: G, Wani, I, Noyes, G E, Milo, S M, D'Ambrosio

Publikováno v: Molecular medicine (Cambridge, Mass.). 3(4)

BACKGROUND: The overexpression or amplification of tumor suppressor and proto-oncogenes are important factors in the progression of breast cancer. Recent attention has focused on the cyclin genes, whose involvement in signal transduction pathways reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9585c94c961a2cea293f20f30a6e0048
https://pubmed.ncbi.nlm.nih.gov/9131589

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