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Rearrangement of the Genes of Vesicular Stomatitis Virus Eliminates Clinical Disease in the Natural Host: New Strategy for Vaccine Development

Autor: E. B. Flanagan, G. W. Wertz, Luis L. Rodriguez, L. A. Ball, J. M. Zamparo

Publikováno v: Journal of Virology. 75:6107-6114

Gene expression among the nonsegmented negative-strand RNA viruses is controlled by distance from the single transcriptional promoter, so the phenotypes of these viruses can be systematically manipulated by gene rearrangement. We examined the potenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba55e30d445bd798e55678de06e8a74c
https://doi.org/10.1128/jvi.75.13.6107-6114.2001

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Human cytotoxic T cells stimulated by antigen on dendritic cells recognize the N, SH, F, M, 22K, and 1b proteins of respiratory syncytial virus

Autor: Peter J. M. Openshaw, A.H. Cherrie, K. Anderson, G. W. Wertz

Publikováno v: Journal of Virology. 66:2102-2110

We examined the human cytotoxic T-cell repertoire of nine adults to 9 of the 10 proteins of respiratory syncytial (RS) virus. Peripheral blood mononuclear cells from normal adults were stimulated with RS virus in vitro. The resulting polyclonal cultu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52989c08914100c577bf223743144cab
https://doi.org/10.1128/jvi.66.4.2102-2110.1992

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The 22,000-kilodalton protein of respiratory syncytial virus is a major target for Kd-restricted cytotoxic T lymphocytes from mice primed by infection

Autor: B. A. Askonas, Peter J. M. Openshaw, K. Anderson, G. W. Wertz

Publikováno v: Journal of Virology. 64:1683-1689

Recombinant vaccinia viruses containing the 22-kilodalton protein (matrixlike or 22K protein) or phosphoprotein gene from respiratory syncytial virus were constructed. These recombinant viruses expressed proteins which were immunoprecipitated by appr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f51edebd7329e48c3c5cdc66afeff31
https://doi.org/10.1128/jvi.64.4.1683-1689.1990

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Transcription and replication of nonsegmented negative-strand RNA viruses

Autor: S P J, Whelan, J N, Barr, G W, Wertz

Publikováno v: Current topics in microbiology and immunology. 283

The nonsegmented negative-strand (NNS) RNA viruses of the order Mononegavirales include a wide variety of human, animal, and plant pathogens. The NNS RNA genomes of these viruses are templates for two distinct RNA synthetic processes: transcription t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d58e9bf8730a7e342f0e700e111dfc4e
https://pubmed.ncbi.nlm.nih.gov/15298168

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Gene rearrangement attenuates expression and lethality of a nonsegmented negative strand RNA virus

Autor: G W Wertz, V P Perepelitsa, L A Ball

The nonsegmented negative strand RNA viruses comprise hundreds of human, animal, insect, and plant pathogens. Gene expression of these viruses is controlled by the highly conserved order of genes relative to the single transcriptional promoter. We ut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1d0a10d66fd4e1e78d25660d3ab514
https://europepmc.org/articles/PMC19865/

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Synthetic oligonucleotide probes differentiate respiratory syncytial virus subgroups in a nucleic acid hybridization assay

Autor: G W Wertz, Wayne M. Sullender

A new approach to respiratory syncytial virus subgroup differentiation has been developed on the basis of the hybridization of subgroup-specific synthetic oligonucleotides with viral mRNA. Two oligonucleotide probes were designed from the nucleotide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56541a24bdb7db2a8fa3265fd14cf06
https://europepmc.org/articles/PMC271971/

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RNase III cleaves vesicular stomatitis virus genome-length RNAs but fails to cleave viral mRNA's

Autor: G W Wertz, N L Davis

Publikováno v: Journal of Virology. 30:108-115

The procaryotic RNA processing enzyme RNase III (endoribonuclease III [EC 3.1.4.24]) was used to probe vesicular stomatitis virus (VSV) RNAs for specific sites that could be recognized and cleaved. The effect of the enzyme on the RNAs was monitored b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd816488924393257341018dd32157f1
https://doi.org/10.1128/jvi.30.1.108-115.1979

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Method of examining viral RNA metabolism in cells in culture: metabolism of vesicular stomatitis virus RNA

Autor: G W Wertz

Publikováno v: Journal of Virology. 16:1340-1344

A method is described for radioactively labeling viral RNA and then quickly halting further incorporation of radioactive precursor into RNA so that the fate of the labeled RNA can be followed. Small complementary RNAs synthesized during vesicular sto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb004ccbbad97382017c0028895c39ef
https://doi.org/10.1128/jvi.16.5.1340-1344.1975

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Identification of a tenth mRNA of respiratory syncytial virus and assignment of polypeptides to the 10 viral genes

Autor: Yung T. Huang, P L Collins, G W Wertz

Publikováno v: Journal of Virology. 49:572-578

Nine mRNAs, their cDNA clones, and a genome transcriptional map have been reported previously for respiratory syncytial virus (P. L. Collins and G. W. Wertz, Proc. Natl. Acad. Sci. U.S.A. 80:3208-3212, 1983). We report here the identification of a 10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13fde73e0a09947b21d293a483b5362
https://doi.org/10.1128/jvi.49.2.572-578.1984

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