Výsledky vyhledávání - "G. W. Newman"

Cytokines Enhance Neutrophils from Human Immunodeficiency Virus‐Negative Donors and AIDS Patients to Inhibit the Growth ofMycobacterium aviumIn Vitro

Autor: G. W. Newman, Joseph R. Guarnaccia, Heinz G. Remold, Powel Kazanjian

Publikováno v: The Journal of Infectious Diseases. 175:891-900

Mycobacterium avium is one of the most prevalent opportunistic infections in AIDS patients, and neither prophylaxis nor treatment against M. avium is effective. To evaluate host defense mechanisms against mycobacterial infections, studies investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0283928aeda68372a339a820e043a4
https://doi.org/10.1086/513987

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Plasminogen activator inhibitor type 2 prevents programmed cell death of human macrophages infected with Mycobacterium avium, serovar 4

Autor: H Gan, G W Newman, H G Remold

Publikováno v: The Journal of Immunology. 155:1304-1315

Although Mycobacterium avium is usually nonpathogenic in healthy individuals, in vitro infection of macrophages (M phi) from the majority of healthy donors induces death of the cells 2 wk after infection; this effect is in contrast to noninfected M p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0eb8f15dd167774be0cd6754091312f5
https://doi.org/10.4049/jimmunol.155.3.1304

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Human macrophages acquire a hyporesponsive state of tumor necrosis factor alpha production in response to successive Mycobacterium avium serovar 4 stimulation

Autor: Huixian Gan, G. W. Newman, Heinz G. Remold

Publikováno v: Infection and Immunity. 63:1921-1926

Human macrophages (M phi) from most donors respond to inoculation with Mycobacterium avium serovar 4 (M. avium) by tumor necrosis factor alpha (TNF-alpha) production, which is of critical importance for proper defense against microorganisms. An initi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb3de7e41729b131e1808791349527a
https://doi.org/10.1128/iai.63.5.1921-1926.1995

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Opposing regulatory effects of thioredoxin and eosinophil cytotoxicity-enhancing factor on the development of human immunodeficiency virus 1

Autor: Heinz G. Remold, G. W. Newman, D S Silberstein, Joseph R. Guarnaccia, M K Balcewicz-Sablinska

Publikováno v: The Journal of Experimental Medicine

Exogenous recombinant human thioredoxin (rTRX, > or = 500 nM), a dithiol reductase enzyme, inhibited the expression of human immunodeficiency virus (HIV) 1BaL in human macrophages (M phi) by 71% (range, 26-100%), as evaluated by p24 antigen productio

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https://doi.org/10.1084/jem.180.1.359

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Survival of human macrophages infected with Mycobacterium avium intracellulare correlates with increased production of tumor necrosis factor-alpha and IL-6

Autor: G W Newman, H X Gan, P L McCarthy, H G Remold

Publikováno v: The Journal of Immunology. 147:3942-3948

The long term survival of peripheral blood derived human macrophages (M phi) from normal, healthy donors after infection with Mycobacterium avium intracellulare (MAI) correlates with the increased induction of TNF-alpha and IL-6 mRNA and protein by t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e9d8c902715025858f481c061fa5990
https://doi.org/10.4049/jimmunol.147.11.3942

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Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host disease

Autor: Colin A. Sieff, Sunil Abhyankar, James L. M. Ferrara, G. W. Newman, Neben S, Philip L. McCarthy, Steven J. Burakoff, Robert C. Thompson

Publikováno v: Blood. 78:1915-1918

Graft-versus-host disease (GVHD) is the major complication of allogeneic bone marrow transplantation (BMT). Dysregulation of inflammatory monokines such as tumor necrosis factor alpha (TNF alpha) has been noted in both clinical and experimental GVHD.

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https://doi.org/10.1182/blood.v78.8.1915.1915

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Increased macrophage infiltration of gastric mucosa in Helicobacter pylori-infected children

Autor: A E, Whitney, T S, Emory, A M, Marty, P A, O'Shea, G W, Newman, B D, Gold

Publikováno v: Digestive diseases and sciences. 45(7)

The purpose of the study was to quantify gastric mucosal macrophages and define their association with the histopathologic features of stomach biopsies obtained from Helicobacter pylori-infected and uninfected children. Endoscopically obtained gastri

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https://pubmed.ncbi.nlm.nih.gov/10961712

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Virulence Determinants of Mycobacterium tuberculosis

Autor: G. W. Newman, F. D. Quinn, C. H. King

Publikováno v: Current Topics in Microbiology and Immunology ISBN: 9783642801686

Microbial pathogenicity has been defined as “the biochemical mechanisms whereby microorganisms cause disease” (Smith 1968); however, the actual process is much more dramatic. The interaction between host and pathogen during disease is a dynamic c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b07f75b133f78e9c079abba5651feec
https://doi.org/10.1007/978-3-642-80166-2_6