Zobrazeno 1 - 10
of 29
pro vyhledávání: '"G. W. G. Sharp"'
Publikováno v:
Bioscience Reports. 21:653-666
In rat islets, progesterone caused a prompt concentration-dependent inhibition of glucose-stimulated insulin release with an IC50 of 10 μM at 8.4 mM glucose. The inhibition was specific since both testosterone and 17β-estradiol had no such effect.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18690b4dffd3a45f7974077826ed33af
https://doi.org/10.1023/a:1014773010350
https://doi.org/10.1023/a:1014773010350
Autor:
G. W. G. Sharp, Shao Hua Tang
Publikováno v:
Diabetes. 47:905-912
Carbachol-stimulated insulin release in the RINm5F cell is associated with elevation of the cytosolic Ca2+ concentration ([Ca2+]i) through mobilization of Ca2+ from thapsigargin-sensitive intracellular stores and with the generation of diacylglycerol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda4e3325c85a2133be48d1eb09c5e85
https://doi.org/10.2337/diabetes.47.6.905
https://doi.org/10.2337/diabetes.47.6.905
Autor:
Mitsuhisa Komatsu, G. W. G. Sharp
Publikováno v:
Diabetes. 47:352-357
Under Ca2+-free conditions, activation of the pancreatic beta-cell with forskolin and 12-O-tetradecanoylphorbol 13-acetate (TPA) is permissive for the augmentation of insulin release by glucose and other nutrients. The ability of fatty acids to mimic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9015d0120c6348a3cc80013f2a619857
https://doi.org/10.2337/diabetes.47.3.352
https://doi.org/10.2337/diabetes.47.3.352
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 250:G691-G697
The effects of 3,4,5-trimethoxybenzoate 8-(N,N-diethylamino)octyl ester (TMB-8), an agent that traps calcium within intracellular stores, were studied on active electrolyte transport in rabbit ileum under basal conditions and after altering transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459d842f198b91fd04ca23e9ee7678bf
https://doi.org/10.1152/ajpgi.1986.250.5.g691
https://doi.org/10.1152/ajpgi.1986.250.5.g691
Publikováno v:
Journal of Clinical Investigation. 83:1953-1962
Calcium/calmodulin is involved in the regulation of basal rabbit ileal active Na and Cl absorption, but the mechanism by which elevated intracellular Ca2+ affects Na and Cl transport is unknown. To investigate the roles of the Ca2+/calmodulin and pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570316eab9fdcf438141486f804df445
https://doi.org/10.1172/jci114104
https://doi.org/10.1172/jci114104
Autor:
G W G Sharp, J Fischer
Publikováno v:
Biochemical Journal. 176:505-510
A comparison was made of the effects of cholera toxin and p[NH]ppG on the binding affinity of beta-adrenergic receptors in toad erythrocyte membranes. This was determined by studying the ability of isoproterenol and propranolol to compete for the rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd2b78129041a4cee73e88034e3be081
https://doi.org/10.1042/bj1760505
https://doi.org/10.1042/bj1760505
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 254:G543-G551
Basolateral plasma membranes play an integral role in coupling of stimulus to secretion of fluid and protein from the lacrimal gland. To determine if basolateral plasma membranes contain Ca2+- or adenosine 3', 5'-cyclic monophosphate (cAMP)-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd377a3247b2cfba15efab63581e986
https://doi.org/10.1152/ajpgi.1988.254.4.g543
https://doi.org/10.1152/ajpgi.1988.254.4.g543
Publikováno v:
Clinical Infectious Diseases. 8:S188-S201
The gastrointestinal tract is involved in both absorption and secretion of electrolytes and water, with absorption as the predominant process. In diarrheal diseases this balance is disturbed, and the result is net secretion. Most of the drugs used fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45652be64b724ab6ad632d9c9686fdd7
https://doi.org/10.1093/clinids/8.supplement_2.s188
https://doi.org/10.1093/clinids/8.supplement_2.s188
Autor:
J. McCullen, James L. Madara, K. Malmstrom, E. Emmer, Mark Donowitz, L. Reinlib, Richard P. Rood, G. W G Sharp, Michael Cohen, Heini Murer
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 252:G723-G735
High-voltage discharge or one cycle of freeze-thawing are shown to transiently permeabilize rabbit ileal brush-border membrane vesicles to macromolecules. Uptake of the radiolabeled macromolecule dextran, mol wt 70,000, used as a marker for vesicle p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da44a19b02a4fbf35167daf431a20cc
https://doi.org/10.1152/ajpgi.1987.252.6.g723
https://doi.org/10.1152/ajpgi.1987.252.6.g723
Publikováno v:
Journal of Endocrinology. 24:159-169
SUMMARY 1. An investigation of the mechanism of diurnal excretory rhythms has been carried out on four healthy male subjects in whom the excretory rhythms were reversed by a 12 hr. shift of the activity—sleep and light—dark schedules. 2. The diur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faacdd8ec1d11997d27662e7dbf17527
https://doi.org/10.1677/joe.0.0240159
https://doi.org/10.1677/joe.0.0240159