Analysis of enhancement at small and large radiation doses for effectiveness of inactivation in cultured cells by combining two agents with radiation

Autor: Johannes Crezee, Nicolaas A. P. Franken, G. W. Barendsen, H. Petra Kok

Publikováno v: International journal of radiation biology, 92(9), 521-526. Informa Healthcare

To evaluate the enhancement effect of two combined radiation-sensitizing agents in mammalian cells at small doses as compared to large doses using the linear-quadratic (LQ) mathematical model. Data on clonogenic assays concerning the radio-enhancemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd2cd7e350fedc92a49e4067bc9fbe82
https://doi.org/10.1080/09553002.2016.1206226

Decay of γ-H2AX foci correlates with potentially lethal damage repair in prostate cancer cells

Autor: Nicolaas A. P. Franken, Lukas J.A. Stalpers, Hans M. Rodermond, Ahmed Güçlü, Suzanne Hovingh, Bregje van Oorschot, Nienke Losekoot, G. W. Barendsen, Albert A. Geldof

Publikováno v: Oncology Reports, 29(6), 2175-2180. Spandidos Publications
Oncology reports, 29(6), 2175-2180. Spandidos Publications
Van Oorschot, B, Hovingh, S E, Rodermond, H, Guclu, A, Losekoot, N, Geldof, A A, Barendsen, G W, Stalpers, LJ & Franken, N A P 2013, ' Decay of gamma-H2AX foci correlates with potentially lethal damage repair in prostate cancer cells ', Oncology Reports, vol. 29, no. 6, pp. 2175-2180 . https://doi.org/10.3892/or.2013.2364

To determine the relationship between ionizing radiation-induced levels of γ-H2AX foci and cell survival in cultured prostate cancer cell lines, three prostate cancer cell lines: LNCaP (wt TP53), DU145 (mut TP53) and PC3 (TP53 null), were studied. F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f31c8d45d74311b24b2a8a5d6bd99a
https://doi.org/10.3892/or.2013.2364

Dynamics of chromosomal aberrations, induction of apoptosis, BRCA2 degradation and sensitization to radiation by hyperthermia

Autor: Lukas J.A. Stalpers, Hans M. Rodermond, G. W. Barendsen, Rosemarie ten Cate, Arlene L. Oei, Nicolaas A. P. Franken, Judith W.J. Bergs

Publikováno v: International journal of molecular medicine, 38(1), 243-250. Spandidos Publications

Hyperthermia can transiently degrade BRCA2 and thereby inhibit the homologous recombination pathway. Induced DNA-double strand breaks (DSB) then have to be repaired via the error prone non-homologous end-joining pathway. In the present study, to inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccea4b722a0c9b2ed1c94f30e3eae2cc
https://pubmed.ncbi.nlm.nih.gov/27246457

Enhancement of the effectiveness of methotrexate for the treatment of solid tumours by application of local hyperthermia

Autor: E. M. Schopman, G. W. Barendsen, C. van Bree, J. B. A. Kipp

Publikováno v: International Journal of Hyperthermia. 11:561-573

Investigations were performed to assess the influence of hyperthermia on the pharmacokinetics of a chemotherapeutic drug and on the effectiveness of combined treatments for induction of tumour cell death and growth delay of experimental tumours. Trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05486e4276dc1ebe9befd390db40a4b
https://doi.org/10.3109/02656739509022490

Radiosensitization with Hyperthermia and Chemotherapeutic Agents: Effects on Linear-Quadratic Parameters of Radiation Cell Survival Curves

Autor: Judith W.J. Bergs, Chris van Bree, Arlene L. Oei, Lukas J.A. Stalpers, Johannes Crezee, Hans M. Rodermond, G. W. Barendsen, Petra Kok, Paul Cobussen, Suzanne Hovingh, Nicolaas A. P. Franken

Publikováno v: Current Topics in Ionizing Radiation Research
P. Franken, N A, Hovingh, S, Oei, A, Cobussen, P, J. Bergs, J W, van, C, Rodermond, H, Stalpers, L, Kok, P, W., G & Crezee, J 2012, Radiosensitization with Hyperthermia and Chemotherapeutic Agents: Effects on Linear-Quadratic Parameters of Radiation Cell Survival Curves . in Current Topics in Ionizing Radiation Research . Current Topics in Ionizing Radiation Research, Intech . https://doi.org/10.5772/34939

Radiosensitization effects of hyperthermia and chemotherapeutic agents as currently exploited in the clinic are discussed with respect to the linear quadratic parameters of dosesurvival curve presentations. Studies of different human tumour cell line

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd815f6aa68e4ecde49b4b5934cc1de
http://www.intechopen.com/articles/show/title/radiosensitization-with-hyperthermia-and-chemotherapeutic-agents-effects-on-linear-quadratic-paramet