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Radioimmunoassay of unprocessed sheep blood extracts to follow angiotensin metabolism

Autor: J. C. Mackenzie, E. C. Osborn, G. V. Rigby, P. L. Sugden, A. Wilton

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 233:H527-H534

The acceptability of radioimmunoassay to determine the levels of compounds antigenic to anti-angiotensin antibodies, in unprocessed methanolic blood extracts, was established for sheep blood. This approach was used to follow the clearance of antigeni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9bdada9d866aba03fc882534c9b4f14
https://doi.org/10.1152/ajpheart.1977.233.4.h527

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Propantheline bromide plasma level, urinary excretion and pharmacological data in a comparison of the bioavailability of three oral formulations of Pro-Banthine

Autor: JR Shelton, E. F. Allan, Joan M Clarke, R. D. Brownsill, N. J. Haskins, R. F. Palmer, RM Perkins, A. J. Hawkins, G. C. Ford, Ian R Harrison, C. W. Vose, G. V. Rigby

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 8:219-224

To determine the comparative bioavailability of three oral formulations of propantheline bromide (PB) by both pharmacokinetic and pharmacodynamic parameters, six normal men received three standard Pro-Banthine 15 mg tablets, two prolonged acting (PA)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e292772e998995434604db7a807b896a
https://doi.org/10.1007/bf03188751

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Diuretic induced hypokalaemia: relationship to dosage interval and plasma aldosterone

Autor: JR Shelton, IR Harrison, GT McInnes, G. V. Rigby, RM Perkins

Publikováno v: British Journal of Clinical Pharmacology. 14:449-452

Plasma potassium and aldosterone responses to 9 days treatment with hydrochlorothiazide (100 mg/day) alone or in combination with spironolactone (100 mg/day), prescribed once daily or in doses 12 h apart, were examined in a double-blind, crossover st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4846d96d90c5a7fe944ef07d02058fc
https://doi.org/10.1111/j.1365-2125.1982.tb02007.x

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Do angiotensin-induced changes in sheep renal venous blood and plasma composition indicate a reversal of glomerular filtration?

Autor: L.M. Fearn, J.C. Mackenzie, G. V. Rigby, M.W. Rodgers, J. Wilson, E.C. Osborn, O. F. Mason

Publikováno v: Medical hypotheses. 23(2)

Angiotensin II markedly lowers the relative cell content of renal venous blood both with injection into the jugular vein and into the left ventricle of anaesthetised sheep; angiotensin I has a similar effect in this regard when given intravenously bu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49516b5b4a04b210996798efd9a79ffa
https://pubmed.ncbi.nlm.nih.gov/3614007

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Influence of angiotensin II on the concentration of arterial plasma electrolytes in anaesthetized sheep

Autor: P. L. Sugden, I. D. Chapman, E. C. Osborn, S. Howes, J. C. Mackenzie, D. M. Aitken, J. Wilson, G. V. Rigby, O. F. Mason

Publikováno v: The Journal of endocrinology. 104(1)

Angiotensin II and I significantly raised potassium and lowered sodium and chloride ion concentrations in arterial plasma, with peak changes occurring in the first 2 min of a 6-min infusion period. The octapeptide increased the arterial K+ level in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25639e6b000824082410ad9cdaba0034
https://pubmed.ncbi.nlm.nih.gov/3968498

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