Výsledky vyhledávání - "G. V. Fazakerley"

Solution Structure by NMR and Molecular Dynamics of a Duplex Containing a Guanine Opposite aN-(2-Deoxy-β-d-erythro-pentofuranosyl)formamide Lesion

Autor: C. Maufrais, Jean Cadet, Yves Boulard, G. V. Fazakerley

Publikováno v: Biochemistry. 39:5614-5621

One- and two-dimensional NMR spectroscopy has been used combined with molecular dynamics to determine the fine structure of the DNA duplex 5'-d(AGGAGCCACG).d(CGTGGFTCCT) where F is the N-(2-deoxy-beta-D-erythro-pentofuranosyl)formamide residue which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101bd92b5692f2dbfb4a1b0ada81b8df
https://doi.org/10.1021/bi9928849

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Solution structures of oligonucleotides containing either a guanine or a cytosine in front of a gap of one nucleotide

Autor: G. V. Fazakerley, V. Faibis, Y. Boulard

Publikováno v: Journal de Chimie Physique et de Physico-Chimie Biologique. 96:1566-1572

Nous presentons une etude par RMN et modelisation moleculaire sur deux duplexes d'ADN contenant une lacune de un nucleotide. La difference entre les deux oligonucleotides reside dans la base centrale en face de la lacune, une guanine ou une cytosine.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3507b38564a790d316cbad01fa89f83
https://doi.org/10.1051/jcp:1999234

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NMR Structure of an Oligonucleotide Containing A Base Pair 3-(2-Hydroxyethyl) Deoxyuridine-Adenine

Autor: G. V. Fazakerley, Yves Boulard, Lawrence C. Sowers

Publikováno v: Nucleosides and Nucleotides. 18:1603-1607

It has been shown that ethylene oxide reacts with dC at the N3 position to produce a potentially mutagenic lesion, 3-(2-hydroxyethyl) deoxyuridine (3-HE-dU). In this article, we report NMR and Molecular Mechanic studies of a duplex containing the 3-H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc49492ddcaa59dd815d0d44267b5512
https://doi.org/10.1080/07328319908044797

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Solution Structure of N-(2-Deoxy-d-erythro-pentofuranosyl)urea Frameshifts, One Intrahelical and the Other Extrahelical, by Nuclear Magnetic Resonance and Molecular Dynamics

Autor: A. Guy, R. Teoule, J. Cadet, Virginie Gervais, Jean A. H. Cognet, G. V. Fazakerley

Publikováno v: Biochemistry. 37:1083-1093

The presence of a N-(2-deoxy-D-erythro pentofuranosyl)urea (henceforth referred to as deoxyribosylurea) residue, ring fragmentation product of a thymine, in a frameshift situation in the sequence 5'd(AGGACCACG).d(CGTGGurTCCT) has been studied by 1H a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a0e64f372028cf9f251215498b1825
https://doi.org/10.1021/bi971202j

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Solution structure as a function of pH of two central mismatches, C·T and C·C, in the 29 to 39 K- ras gene sequence, by nuclear magnetic resonance and molecular dynamics 1 1Edited by T. Tinoco

Autor: Yves Boulard, J.A.H. Cognet, G. V. Fazakerley

Publikováno v: Journal of Molecular Biology. 268:331-347

The DNA duplexes 5' d(GCCACCAGCTC) x d(GAGCTXGTGGC), where the base X is either cytosine or thymine, have been studied by one and two-dimensional nuclear magnetic resonance, energy minimization and molecular dynamics. The sequence studied corresponds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ef1351cd3c12cceac70a9ce59efe999
https://doi.org/10.1006/jmbi.1997.0975

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Solution Structure of an Oncogenic DNA Duplex, the K-rasGene and the Sequence Containing a Central C·A or A·G Mismatch as a Function of pH: Nuclear Magnetic Resonance and Molecular Dynamics Studies

Autor: J.A.H. Cognet, M. Le Bret, J. Gabarro-Arpa, C. Carbonnaux, Yves Boulard, G. V. Fazakerley

Publikováno v: Journal of Molecular Biology. 246:194-208

The DNA duplex 5′ d(GCCACCAGCTC)-d(GAGCTGGTGGC) corresponds to the sequence 29 to 39 of the K- ras gene, which contains a hot spot for mutations. This has been studied by one and two-dimensional nuclear magnetic respnance, energy minimization and m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7ac24c0890b9c19376a4269b668398
https://doi.org/10.1006/jmbi.1994.0076

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Helical Parameters, Fluctuations, Alternative Hydrogen Bonding, and Bending in Oligonucleotides Containing a Mistmatched Base-pair by NOESY Distance Restrained and Distance Free Molecular Dynamics

Autor: J.A.H. Cognet, G. V. Fazakerley, Yves Boulard

Publikováno v: Journal of Molecular Biology. 246:209-226

We have analysed and compared the molecular structures and dynamics of the DNA duplex, that corresponds to the sequence 29 to 39 of the K-ras gene, where the central base-pair is the normal C.G base or a mismatch base-pair C.A, C.A+, A.G and A+.G. Mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc248caf8ccb5a445c6d35f55b0dfd5
https://doi.org/10.1006/jmbi.1994.0077

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Structures of Oligonucleotides Containing 5-(methoxymethyl)-2′-deoxyuridine Determined by NMR Spectroscopy

Autor: S. Mellac, Lawrence C. Sowers, G. V. Fazakerley

Publikováno v: Journal of Biomolecular Structure and Dynamics. 11:1017-1033

Base pairing of 5-(methoxymethyl)-2'-deoxyuridine (MMdU) opposite either adenine or guanine in a seven base pair oligonucleotide duplex has been studied by NMR spectroscopy. When paired with A, we observe that the MMdU.A base pair adopts Watson-Crick

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90286c617737fad1630381d7a4a70b4a
https://doi.org/10.1080/07391102.1994.10508049

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Allosteric and catalytic binding of S-adenosylmethionine to Escherichia coli DNA adenine methyltransferase monitored by 3H NMR

Autor: W Guschlbauer, A Bergerat, G V Fazakerley

Publikováno v: Proceedings of the National Academy of Sciences. 88:6394-6397

Adenine methylation of GATC sequences in DNA is carried out by the DNA adenine methyltransferase with the methyl group source being the cofactor S-adenosylmethionine. We report 3H NMR studies on the interaction of DNA adenine methyltransferase with S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00310f4cb608bcf265a0719d7d67ef6
https://doi.org/10.1073/pnas.88.15.6394

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