Zobrazeno 1 - 10
of 1 788
pro vyhledávání: '"G. Tomlinson"'
Autor:
N. Timilshina, A. Finelli, P. Richard, M. Komisarenko, L. Martin, G. Tomlinson, B. Sander, S. Alibhai
Publikováno v:
European Urology Open Science, Vol 19, Iss , Pp e1907- (2020)
Externí odkaz:
https://doaj.org/article/03ff02eb61b84188b1d85fbf5953011f
Autor:
Christopher B. Nelson, Samuel Rogers, Kaushik Roychoudhury, Yaw Sing Tan, Caroline J. Atkinson, Alexander P. Sobinoff, Christopher G. Tomlinson, Anton Hsu, Robert Lu, Eloise Dray, Michelle Haber, Jamie I. Fletcher, Anthony J. Cesare, Rashmi S. Hegde, Hilda A. Pickett
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The Eyes Absent proteins (EYA1-4) are a biochemically unique group of tyrosine phosphatases known to be tumour-promoting across a range of cancer types. To date, the targets of EYA phosphatase activity remain largely uncharacterised. Here, w
Externí odkaz:
https://doaj.org/article/c6f9e1aee6c04251a8ad3f7b91d37b75
Autor:
Joanne C. Clark, Eleyna M. Martin, Luis A. Morán, Ying Di, Xueqing Wang, Malou Zuidscherwoude, Helena C. Brown, Deirdre M. Kavanagh, Johan Hummert, Johannes A. Eble, Bernhard Nieswandt, David Stegner, Alice Y. Pollitt, Dirk-Peter Herten, Michael G. Tomlinson, Angel García, Steve P. Watson
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Fluorescence correlation spectroscopy on crosslinked nanobodies tested on C-type lectin-like receptor 2 (CLEC-2) show different outcomes for divalent and tetravalent nanobody ligands on CLEC-2 clustering, also dependent on CLEC-2 expression levels.
Externí odkaz:
https://doaj.org/article/7459f6954fe94e3e8043691e4c0d8e5b
Autor:
Chukiat Tantiwong, Joanne L. Dunster, Rachel Cavill, Michael G. Tomlinson, Christoph Wierling, Johan W. M. Heemskerk, Jonathan M. Gibbins
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Receptor diffusion plays an essential role in cellular signalling via the plasma membrane microenvironment and receptor interactions, but the regulation is not well understood. To aid in understanding of the key determinants of receptor diff
Externí odkaz:
https://doaj.org/article/2abb3eaafda6408294a30fc4910406b0
Autor:
Rodney G. Tomlinson
An avid reader of naval history since my father's service in World War II, I had been struck by the marked contrast between the touching personal depictions of WW II photo-journalism and the dearth of portrayals of sailors as persons, not just undefi
Autor:
Zahra Maqsood, Joanne C Clark, Eleyna M Martin, Yam Fung Hilaire Cheung, Luis A Morán, Sean E T Watson, Jeremy A Pike, Ying Di, Natalie S Poulter, Alexandre Slater, Bodo M H Lange, Bernhard Nieswandt, Johannes A Eble, Mike G Tomlinson, Dylan M Owen, David Stegner, Lloyd J Bridge, Christoph Wierling, Steve P Watson
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 11, p e1010708 (2022)
The clustering of platelet glycoprotein receptors with cytosolic YxxL and YxxM motifs, including GPVI, CLEC-2 and PEAR1, triggers activation via phosphorylation of the conserved tyrosine residues and recruitment of the tandem SH2 (Src homology 2) dom
Externí odkaz:
https://doaj.org/article/4aa0aa11395e4e1d8253e586a4861727
Autor:
Lisiena Hysenaj, Samantha Little, Kayla Kulhanek, Melia Magnen, Kriti Bahl, Oghenekevwe M. Gbenedio, Morgan Prinz, Lauren Rodriguez, Christopher Andersen, Arjun Arkal Rao, Alan Shen, Jean-Christophe Lone, Leonard C. Lupin-Jimenez, Luke R. Bonser, Nina K. Serwas, Eran Mick, Mir M. Khalid, Taha Y. Taha, Renuka Kumar, Jack Z. Li, Vivianne W. Ding, Shotaro Matsumoto, Mazharul Maishan, Bharath Sreekumar, Camille Simoneau, Irina Nazarenko, Michael G. Tomlinson, Khajida Khan, Anne von Gottberg, Alex Sigal, Mark R. Looney, Gabriela K. Fragiadakis, David M. Jablons, Charles R. Langelier, Michael Matthay, Matthew Krummel, David J. Erle, Alexis J. Combes, Anita Sil, Melanie Ott, Johannes R. Kratz, Jeroen P. Roose
Publikováno v:
Stem Cell Reports
Stem cell reports, vol 18, iss 3
Stem cell reports, vol 18, iss 3
Ancestral SARS coronavirus-2 (SARS-CoV-2) and variants of concern (VOC) caused a global pandemic with a spectrum of disease severity. The mechanistic explaining variations related to airway epithelium are relatively understudied. Here, we biobanked a
Autor:
Bishnu P Paudel, Aaron Lavel Moye, Hala Abou Assi, Roberto El-Khoury, Scott B Cohen, Jessica K Holien, Monica L Birrento, Siritron Samosorn, Kamthorn Intharapichai, Christopher G Tomlinson, Marie-Paule Teulade-Fichou, Carlos González, Jennifer L Beck, Masad J Damha, Antoine M van Oijen, Tracy M Bryan
Publikováno v:
eLife, Vol 9 (2020)
Telomeric G-quadruplexes (G4) were long believed to form a protective structure at telomeres, preventing their extension by the ribonucleoprotein telomerase. Contrary to this belief, we have previously demonstrated that parallel-stranded conformation
Externí odkaz:
https://doaj.org/article/44d7e6c98c07413a81971b3cbc70d688
Autor:
Peter J. Noy, Rebecca L. Gavin, Dario Colombo, Elizabeth J. Haining, Jasmeet S. Reyat, Holly Payne, Ina Thielmann, Adam B. Lokman, Georgiana Neag, Jing Yang, Tammy Lloyd, Neale Harrison, Victoria L. Heath, Chris Gardiner, Katharine M. Whitworth, Joseph Robinson, Chek Z. Koo, Alessandro Di Maio, Paul Harrison, Steven P. Lee, Francesco Michelangeli, Neena Kalia, G. Ed Rainger, Bernhard Nieswandt, Alexander Brill, Steve P. Watson, Michael G. Tomlinson
Publikováno v:
Haematologica, Vol 104, Iss 9 (2019)
Ca2+ entry via Orai1 store-operated Ca2+ channels in the plasma membrane is critical to cell function, and Orai1 loss causes severe immunodeficiency and developmental defects. The tetraspanins are a superfamily of transmembrane proteins that interact
Externí odkaz:
https://doaj.org/article/72942b750efd4ee2a4e3fd070b4f38e4
Autor:
Elizabeth J. Haining, Alexandra L. Matthews, Peter J. Noy, Hanna M. Romanska, Helen J. Harris, Jeremy Pike, Martina Morowski, Rebecca L. Gavin, Jing Yang, Pierre-Emmanuel Milhiet, Fedor Berditchevski, Bernhard Nieswandt, Natalie S. Poulter, Steve P. Watson, Michael G. Tomlinson
Publikováno v:
Platelets, Vol 28, Iss 7, Pp 629-642 (2017)
The tetraspanins are a superfamily of four-transmembrane proteins, which regulate the trafficking, lateral diffusion and clustering of the transmembrane proteins with which they interact. We have previously shown that tetraspanin Tspan9 is expressed
Externí odkaz:
https://doaj.org/article/450db8670693458ca5e511caed983da9