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Akademický článek
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Publikováno v:
Journal of Neurobiology. 34:304-318
Pancreatic islets are enveloped by a sheath of Schwann cells, the glial cells of the peripheral nervous system (PNS). The fact that Schwann cells of the PNS become reactive and express nerve growth factor (NGF) and other growth factors following axot
Publikováno v:
American Journal of Physiology-Renal Physiology. 269:F564-F570
DARPP-32, a dopamine- and adenosine 3',5'-cyclic monophosphate (cAMP)-regulated inhibitor of protein phosphatase-1, is highly colocalized with neuronal and nonneuronal D1-type receptors. DARPP-32 concentration is enriched in the renal outer medulla a
Autor:
Marc Montminy, Christopher V.E. Wright, R. Stein, Laura W. Gamer, J. Leonard, Y. Guz, G. Teitelman
Publikováno v:
Development. 121:11-18
The XlHbox 8 homeodomain protein of Xenopus and STF-1, its mammalian homolog, are selectively expressed by β cells of adult mouse pancreatic islets, where they are likely to regulate insulin expression. We sought to determine whether the expression
Publikováno v:
Molecular Endocrinology. 8:1798-1806
The development of endocrine cell types within the pancreas is thought to involve the progressive restriction of pluripotential stem cells, which gives rise to the four major cell types: insulin-, glucagon-, somatostatin-, and pancreatic polypeptide-
Publikováno v:
Molecular and Cellular Biology. 14:6704-6714
Pancreatic beta-cell-type-specific transcription of the insulin gene is principally regulated by a single cis-acting DNA sequence element, termed the insulin control element (ICE), which is found within the 5'-flanking region of the gene. The ICE act
Autor:
G. Teitelman, Eva Henderson, Roland Stein, Mina Peshavaria, Laura W. Gamer, Christopher V.E. Wright
Publikováno v:
Molecular Endocrinology. 8:806-816
The cis-acting sequences that mediate insulin gene expression exclusively in pancreatic islet beta-cells are localized within the 5'-flanking region between nucleotides -340 and -91. We have identified an evolutionarily conserved, A+T-rich element at
Publikováno v:
Developmental Biology. 163:480-490
Adrenal chromaffin cells and neurons of the sympathetic ganglia are derived from common precursors in the neural crest. The phenotype of the sympathoadrenal progenitor cell is unknown, but adult chromaffin cells are distinguished by the expression of
Autor:
G. L. W. G. Robinson, Mina Peshavaria, Roland Stein, Ming-Jer Tsai, G. Teitelman, Eva Henderson, Sheau-Yann Shieh
Publikováno v:
Scopus-Elsevier
Cell type-specific expression of the major differentiated products of alpha (glucagon) and beta (insulin) cells are regulated by sequences found within their 5'-flanking region. Specific transcription of the insulin gene appears to be principally con