Zobrazeno 1 - 10
of 292
pro vyhledávání: '"G. T. Stevenson"'
Autor:
John W. B. Bradfield
Publikováno v:
The Journal of Pathology. 142:233-234
Autor:
A. Horwich
Publikováno v:
Hematological Oncology. 2:219-219
Autor:
HABESHAW, J
Publikováno v:
Immunology Today; 1984, Vol. 5 Issue: 5 p153-153, 1p
Publikováno v:
The Journal of Immunology. 158:2242-2250
We describe a method for linking human normal Fc gamma1, via stable thioether bonds emerging from its hinge, to any molecule expressing a free sulfhydryl (SH) group. The Fc hinge may be closed by a disulfide (SS) bond or left open. Preparation begins
Publikováno v:
Clinical and Experimental Immunology. 107:364-371
SUMMARY Immunotherapy using MoAbs is inefficient due to limited activation of human effectors by mouse antibodies and multiple protective mechanisms available to host cells against autologous complement. We have used chemically engineered antibody co
Publikováno v:
The Journal of Immunology. 155:925-937
Multiple myeloma is a malignancy of plasma cells for which there is no effective treatment. To develop an immunotherapeutic agent, we have raised a high affinity mAb (AT13/5) against CD38, one of the few well-characterized surface Ags present on myel
Publikováno v:
Cancer Immunology Immunotherapy. 36:149-155
Apoptosis in three lymphoma cell lines has been studied following cytotoxicity induced in vitro by normal human blood lymphocytes utilizing either natural killer (NK) or antibody-dependent cellular cytotoxic (ADCC) mechanisms. Guinea-pig L2C leukaemi
Publikováno v:
Scandinavian Journal of Immunology. 36:221-231
Changes in the intracellular calcium ion concentration ([Ca2+]i) of monocytes, granulocytes, and NK cells have been studied following either (1) independent cross-linking of Fc gamma receptors (Fc gamma R) I, II, or III, with F(ab gamma')2 fragments
Publikováno v:
The Journal of Immunology. 147:60-69
To investigate whether the retargeting of resting CTL can benefit from cooperative signaling between the TCR/CD3 complex and various accessory molecules, such as CD2, CD4, CD5, and CD8, we have constructed a series of trispecific F(ab')3 derivatives.
Publikováno v:
The Journal of Immunology. 146:2461-2468
We have investigated the antigenic modulation induced by a number of antibody fragments and derivatives directed against the idiotype of the surface Ig of the L2C guinea pig B lymphoblastic leukemia, and studied the effects upon such modulation of th