Zobrazeno 1 - 10
of 50
pro vyhledávání: '"G. T. Rogers"'
Publikováno v:
Fatigue under Thermal and Mechanical Loading: Mechanisms, Mechanics and Modelling ISBN: 9789048146888
This paper describes an experimental system developed to conduct thermal mechanical fatigue (TMF) and biaxial fatigue testing of materials. As such the biaxial mechanical loadings may be either pure torsion or combined axial-torsion using thin-wall t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fea3dd5059b188b0479e096422c6185
https://doi.org/10.1007/978-94-015-8636-8_2
https://doi.org/10.1007/978-94-015-8636-8_2
Publikováno v:
Annals of oncology : official journal of the European Society for Medical Oncology. 5(10)
The concept of generating cytotoxic agents from non-toxic prodrugs at tumour sites by antibody vectored enzyme introduces a wide range of opportunities. Various prodrug-enzyme combinations have been described and encouraging results reported in xenog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba07b005404534fdf2abf5272bed595e
https://pubmed.ncbi.nlm.nih.gov/7696159
https://pubmed.ncbi.nlm.nih.gov/7696159
Galactosylated antibodies and antibody-enzyme conjugates in antibody-directed enzyme prodrug therapy
Autor:
S K, Sharma, K D, Bagshawe, P J, Burke, J A, Boden, G T, Rogers, C J, Springer, R G, Melton, R F, Sherwood
Publikováno v:
Cancer. 73
Antibody directed enzyme prodrug therapy (ADEPT) has been studied as a two- and three-phase system in which an antibody to a tumor-associated antigen has been used to deliver an enzyme to tumor sites where it can convert a relatively nontoxic prodrug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ce28a0e737ce4b716a97e68a7d53a7f7
https://pubmed.ncbi.nlm.nih.gov/8306255
https://pubmed.ncbi.nlm.nih.gov/8306255
Autor:
S K, Sharma, K D, Bagshawe, C J, Springer, P J, Burke, G T, Rogers, J A, Boden, P, Antoniw, R G, Melton, R F, Sherwood
Publikováno v:
Disease markers. 9(3-4)
Monoclonal anti-CEA antibody, A5B7, and its fragments conjugated to CPG2 localize to a peak concentration in the LS174T xenografts within 24 h after injection, but enzyme activity persists in plasma such that prodrug injection has to be delayed for 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ec4d2883b2a337754f508781e6f06c8d
https://pubmed.ncbi.nlm.nih.gov/1813212
https://pubmed.ncbi.nlm.nih.gov/1813212
Autor:
K D, Bagshawe, S K, Sharma, C J, Springer, P, Antoniw, J A, Boden, G T, Rogers, P J, Burke, R G, Melton, R F, Sherwood
Publikováno v:
Disease markers. 9(3-4)
Following an extensive series of studies in nude mice with human xenografts a pilot scale clinical trial of antibody directed enzyme prodrug therapy has been initiated. The principle is to activate a relatively inert prodrug to an active cytotoxin by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ecbc23a80e0a843717138cb40ab5d74f
https://pubmed.ncbi.nlm.nih.gov/1813213
https://pubmed.ncbi.nlm.nih.gov/1813213
Publikováno v:
Journal of Aircraft. 13:495-499
It is demonstrated that wing-tip vortices with buoyant cores can be made in a wind tunnel. Wing-tip vortices generated by an aircraft often become buoyant, because of heating effects due to the jet exhaust or in connection with a descending motion in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae6446deee860ffa45ebbda10b92cb51
https://doi.org/10.2514/3.58682
https://doi.org/10.2514/3.58682
Autor:
G. T. Rogers
Publikováno v:
Journal of Applied Electrochemistry. 12:379-391
Galvani, Volta, Davy and Faraday all recognized that life on earth and electrochemistry are intimately connected. The controlled transduction and flow of energy is at the heart of both.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbcad9c3f340a67b1c5ff28327a98ffe
https://doi.org/10.1007/bf00610478
https://doi.org/10.1007/bf00610478
Publikováno v:
British Journal of Cancer
Saline extracts of human bronchogenic tumours, soluble in 50% saturated ammonium sulphate and also fractions from Sephadex G-200 chromatography were used to raise antisera in rabbits. After absorbing the antisera with normal tissue extracts, direct O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd997dd8eed30df78369fd58bd11e33
https://doi.org/10.1038/bjc.1975.77
https://doi.org/10.1038/bjc.1975.77
Autor:
A.C.W. To, R. E. Fray, J. Taylor‐Papadimitriou, K.C. Watts, N. F. Morris, G. T. Rogers, O. A. N. Husain, S. Lader
Publikováno v:
BJOG: An International Journal of Obstetrics and Gynaecology. 91:1037-1041
Summary. This study was designed to determine whether immunohistochemical stains for tumour-associated markers may be useful in the detection and differential diagnosis of premalignant and malignant lesions of the cervix. The expression of four marke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6927eaae525843ee1e2e80a107f076a6
https://doi.org/10.1111/j.1471-0528.1984.tb03684.x
https://doi.org/10.1111/j.1471-0528.1984.tb03684.x
Publikováno v:
British Journal of Cancer
The use of perchloric acid and water for the extraction of CEA from tumour and foetal tissues has been investigated. In the case of tumour, lower recoveries of CEA were obtained from perchloric acid extracts than from aqueous extracts of the same tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ec46c44789989cd8f916adffee6054
https://doi.org/10.1038/bjc.1978.25
https://doi.org/10.1038/bjc.1978.25