Zobrazeno 1 - 10
of 120
pro vyhledávání: '"G. Svahn"'
Autor:
Per-Ola Carlsson, Daniel Espes, Sofia Sisay, Lindsay C. Davies, C. I. Edvard Smith, Mathias G. Svahn
Publikováno v:
Diabetologia.
Aim/hypothesis This study aimed to investigate the safety and efficacy of treatment with allogeneic Wharton’s jelly-derived mesenchymal stromal cells (MSCs) in recent-onset type 1 diabetes. Methods A combined Phase I/II trial, composed of a dose es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9caaf3489987e603d25dd776acf8bbe
https://doi.org/10.1007/s00125-023-05934-3
https://doi.org/10.1007/s00125-023-05934-3
Autor:
Mathias G. Svahn, Per-Ola Carlsson
Publikováno v:
Clinical Trials in Degenerative Diseases, Vol 3, Iss 2, Pp 32-37 (2018)
Background and objectives: The Wharton’s jelly of the umbilical cord tissue contains a high density of mesenchymal stromal cells (MSCs). Wharton’s jelly derived mesenchymal stromal cells have immunosuppressive potential that can be utilized for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48319c37a8b49dac2689f58463d8b490
http://www.clinicaltdd.com/article.asp?issn=2542-3975
http://www.clinicaltdd.com/article.asp?issn=2542-3975
Autor:
Karin E. Lundin, Iulian I. Oprea, Mathias G. Svahn, Pedro Moreno, C. I. Edvard Smith, Oscar E. Simonson, Eman M. Zaghloul
Publikováno v:
Genetica. 137:47-56
In both basic research as well as experimental gene therapy the need to transfer genetic material into a cell is of vital importance. The cellular compartment, which is the target for the genetic material, depends upon application. An siRNA that medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e269cde12abbfb5e75c2e03e64d9561b
https://doi.org/10.1007/s10709-009-9372-0
https://doi.org/10.1007/s10709-009-9372-0
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 26:1501-1504
As initial studies of block coupling of peptides with C-terminal glycines, we have evaluated of coupling of glycine building blocks under various conditions to a preassembled solid support bound LNA-fragment. Potentially competing side reaction have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be940cb97412d4bed98d85e5ea652d0e
https://doi.org/10.1080/15257770701542934
https://doi.org/10.1080/15257770701542934
Autor:
E. Oscar Simonson, Maroof Hasan, Pedro Moreno, Iulian I. Oprea, C. I. Edvard Smith, Karin E. Lundin, Elisabeth Törnquist, Mathias G. Svahn
Publikováno v:
Biomolecular Engineering. 22:185-192
Low cellular uptake and poor nuclear transfer hamper the use of non-viral vectors in gene therapy. Addition of functional entities to plasmids using the Bioplex technology has the potential to improve the efficiency of transfer considerably. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54437c109a0a94c328d18b9f32e0f8c
https://doi.org/10.1016/j.bioeng.2005.07.003
https://doi.org/10.1016/j.bioeng.2005.07.003
Publikováno v:
Karolinska Institutet
Non-viral gene delivery is an important approach in order to establish safe in vivo gene therapy in the clinic. Although viral vectors currently exhibit superior gene transfer efficacy, the safety aspect of viral gene delivery is a concern. In order
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c20bb427aaa6eff79d453142471dd3
https://doi.org/10.2174/138161205774580813
https://doi.org/10.2174/138161205774580813
Publikováno v:
Journal of Controlled Release. 98:169-177
Linking peptide functions directly to nucleic acids can be used to improve transfection. We have previously demonstrated this by sequence-specific hybridization of a bifunctional peptide nucleic acid (PNA) consisting of a nucleic acid binding moiety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20190904ae6bcec2888d91016be24240
https://doi.org/10.1016/j.jconrel.2004.04.012
https://doi.org/10.1016/j.jconrel.2004.04.012
Autor:
Mathias G. Svahn, Mikael Leijon, Karin E. Lundin, Rongbin Ge, Lars Branden, C. I. Edvard Smith, Elisabeth Törnquist
Publikováno v:
Biomolecular Engineering. 21:51-59
Peptide nucleic acid (PNA) is a DNA analog with broad biotechnical applications, and possibly also treatment applications. Its suggested uses include that of a specific anchor sequence for biologically active peptides to plasmids in a sequence-specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0965993913301d2a3dc6271ae02f9f65
https://doi.org/10.1016/j.bioeng.2003.10.003
https://doi.org/10.1016/j.bioeng.2003.10.003
Publikováno v:
Acta Radiologica. 42:218-224
Purpose: To compare the femorotibial rotation, the patellar translation, the hip-knee-ankle angle and the Q-angle in patients with a dislocation of the patella with those of healthy volunteers. Further, the clinically measured Q-angle was compared to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d59e919ee7f15737e949504726dc30e8
https://doi.org/10.1080/028418501127346521
https://doi.org/10.1080/028418501127346521
Publikováno v:
Acta Radiologica. 41:310-316
Purpose: To establish a correlation between radiation dose and diagnostic accuracy when employing a new digital method for angle determinations. The specific intention was to determine how far the radiation dose can be reduced without losing measurin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e1a9d721cd1fc5e8e7488e052a07113
https://doi.org/10.1080/028418500127345541
https://doi.org/10.1080/028418500127345541