The Splicing History of an mRNA Affects Its Level of Translation and Sensitivity to Cleavage by the Virion Host Shutoff Endonuclease during Herpes Simplex Virus Infections

Autor: G. Sullivan Read, Jouliana Sadek

During lytic herpes simplex virus (HSV) infections, the virion host shutoff (Vhs) (UL41) endoribonuclease degrades many cellular and viral mRNAs. In uninfected cells, spliced mRNAs emerge into the cytoplasm bound by exon junction complexes (EJCs) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::029346d299b0a9c5a6d4dccbce1f977d
https://europepmc.org/articles/PMC5110170/

Small Interfering RNAs That Deplete the Cellular Translation Factor eIF4H Impede mRNA Degradation by the Virion Host Shutoff Protein of Herpes Simplex Virus

Autor: Lora A. Shiflett, Nandini Sarma, Deepali Agarwal, G. Sullivan Read

Publikováno v: Journal of Virology. 82:6600-6609

The herpes simplex virus (HSV) virion host shutoff (Vhs) protein is an endoribonuclease that accelerates decay of many host and viral mRNAs. Purified Vhs does not distinguish mRNAs from nonmessenger RNAs and cuts target RNAs at many sites, yet within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e2825f002c5b7e1a67d7a63b15cfdd
https://doi.org/10.1128/jvi.00137-08

mRNA Decay during Herpes Simplex Virus (HSV) Infections: Protein-Protein Interactions Involving the HSV Virion Host Shutoff Protein and Translation Factors eIF4H and eIF4A

Autor: Pinghui Feng, G. Sullivan Read, David N. Everly

Publikováno v: Journal of Virology. 79:9651-9664

During lytic infections, the virion host shutoff (Vhs) protein of herpes simplex virus accelerates the degradation of both host and viral mRNAs. In so doing, it helps redirect the cell from host to viral protein synthesis and facilitates the sequenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf702ef836ee79067f97360a6a82fecb
https://doi.org/10.1128/jvi.79.15.9651-9664.2005

mRNA Degradation by the Virion Host Shutoff (Vhs) Protein of Herpes Simplex Virus: Genetic and Biochemical Evidence that Vhs Is a Nuclease

Autor: G. Sullivan Read, Pinghui Feng, David N. Everly, I. Saira Mian

During lytic infections, the virion host shutoff (Vhs) protein (UL41) of herpes simplex virus destabilizes both host and viral mRNAs. By accelerating the decay of all mRNAs, it helps redirect the cell from host to viral gene expression and facilitate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859bfa59d9d10444952d58f53d3a5e14
https://europepmc.org/articles/PMC136990/

New Ways of Initiating Translation in Eukaryotes?

Autor: M. Holcik, M Jr Gale, S. A. Chappell, J. Hershey, B. He, N. Standart, Robert J. Schneider, N. Nakashima, Jing Chen, J. Pelletier, T. Rouault, D. R. Morris, O. Donzé, J. B. Harford, L. E. Maquat, A. A.M. Thomas, F. Bayard, T. Skern, S. Miyamoto, T. Hohn, A. Siddiqui, Ian Mohr, S. M. Tahara, D. R. Cavener, L. S. Jefferson, R. Andino, Y. Groner, S. Lemon, S. R. Kimball, E. G. Moss, E. Goldman, W. Sossin, B. Joshi, A. Dasgupta, B. J. Lamphear, K. Igarashi, G. Sullivan Read, V. P. Mauro, R. J. Kaufman, Daniel R. Schoenberg, N. Sonenberg, M. Hatzoglou, J. D. Richter, Leslie A. Schiff, R. E. Lloyd, R. M. Krug, P. Hershey, G. Witherell, C. U.T. Hellen, G. C. Scheper, A. C. Prats, V. I. Agol, W. Filipowicz, A. Palmenberg, R. E. Rhoads, M. Kiledjian, J. L.E. Darlix, L. Gehrke, V. Racaniello, P. J. Farabaugh, R. Rivera-Pomar, M. W. Hentze, M. Wormington, O. Elroy-Stein, M. B. Mathews, M. G. Katze, B. L. Semler, T. Pe'ery, N. T. Parkin, A. Sachs, A. Kimchi, Raymond Kaempfer, S. Peltz, R. Jagus, E. V. Pilipenko, C. P. Hunter, K. Kirkegaard, M. Kozak, R. Duncan, A. E. Koromilas, R. Jackson, Encarnación Martínez-Salas, E. Wimmer, T. V. Pestova, V. Kruys, J. Wilusz, P. Sarnow, J. J. Toulmé

Three interesting ideas about the initiation of translation in eukaryotes have recently emerged in the literature. One is the possibility that internal initiation of translation might occur not only with viral but also with some cellular mRNAs. The s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ece8c041f3a06cd631e6d435c8bd8c
https://europepmc.org/articles/PMC86772/