Výsledky vyhledávání

Optimization of precision nanofiber micelleplexes for DNA delivery

Autor: Steven T. G. Street, Hayley C. Parkin, Lennard Shopperly, Josie Chrenek, Keiran Letwin, Stephanie M. Willerth, Ian Manners

Publikováno v: Biomaterials Science. 11:3512-3523

Several factors important for understanding the formation and biological activity of nanofiber micelleplexes are examined and optimized in this work. These studies should inform the future design of more advanced polymeric DNA delivery systems.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c0d7c9820af107504e26433663e3154
https://doi.org/10.1039/d2bm02014a

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Phase III Randomized Trial of Maintenance Taxanes Versus Surveillance in Women With Advanced Ovarian/Tubal/Peritoneal Cancer: A Gynecologic Oncology Group 0212:NRG Oncology Study

Publikováno v: Journal of Clinical Oncology. 40:4119-4128

PURPOSE To compare taxane maintenance chemotherapy, paclitaxel (P) and paclitaxel poliglumex (PP), with surveillance (S) in women with ovarian, peritoneal, or fallopian tube (O/PC/FT) cancer who attained clinical complete response after first-line pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703d9b1ede924d762a06acf7ea13d7aa
https://doi.org/10.1200/jco.22.00146

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Precision polymer nanofibers with a responsive polyelectrolyte corona designed as a modular, functionalizable nanomedicine platform

Autor: Steven T. G. Street, Yunxiang He, Robert L. Harniman, Juan Diego Garcia-Hernandez, Ian Manners

Publikováno v: Polymer Chemistry. 13:3009-3025

Length-controlled polyelectrolyte nanofibers have been produced via Crystallization-Driven Self-Assembly. The morphological effects on long-term stability, enzymatic biodegradability, and cellular toxicity have been studied.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6fc91f355ed576d542d468d65be6716
https://doi.org/10.1039/d2py00152g

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Uniform, length-tunable antibacterial 1D diblock copolymer nanofibers

Autor: Hayley C. Parkin, J. Diego Garcia-Hernandez, Steven T. G. Street, Rebecca Hof, Ian Manners

Publikováno v: Polymer Chemistry. 13:2941-2949

Length-controlled, low dispersity, 1D nanofibers are promising alternatives for treating bacterial infections due to their unique size and shape.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ad041e4d2836d8194c86aa7f9d85fe7
https://doi.org/10.1039/d2py00262k

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Severe Legionella and Histoplasma Pneumonia Acquired From Spring Water

Autor: Natalie G Street, Sohiub N Assaf, Shawnt Tosonian, Elman Urbina Meneses, Megan D Edwards

Publikováno v: Cureus.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e89ba30188dc4d164dd2dc8974272da
https://doi.org/10.7759/cureus.34765

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Loupe a New Generation TEM System for Near Surface Applications

Autor: G. Street

Publikováno v: 5th Asia Pacific Meeting on Near Surface Geoscience & Engineering.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df9e1c87fdca118ac0cfbbe74f051d54
https://doi.org/10.3997/2214-4609.202378035

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Cargo Encapsulation in Uniform, Length-Tunable Aqueous Nanofibers with a Coaxial Crystalline and Amorphous Core

Autor: J. Diego Garcia-Hernandez, Yuetong Kang, Yifan Zhang, Steven T. G. Street, Ian Manners

Publikováno v: Macromolecules. 54:5784-5796

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6117bc1317a20efd7b319be84f583fef
https://doi.org/10.1021/acs.macromol.1c00672

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Imide Condensation as a Strategy for the Synthesis of Core‐Diversified G‐Quadruplex Ligands with Anticancer and Antiparasitic Activity**

Autor: Michael P. O'Hagan, M. Carmen Galan, Juan Carlos Morales, Gregory Hollingworth, Steven T. G. Street, Pablo Peñalver

Publikováno v: Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Street, S, Peñalver, P, O'Hagan, M, Hollingworth, G, Morales, J C & Galan, M C 2021, ' Imide Condensation as a Strategy for the Synthesis of Core-diversified G-quadruplex Ligands with Anti-cancer and Anti-parasitic Activity ', Chemistry-A European Journal, vol. 27, no. 28, pp. 7712-7721 . https://doi.org/10.1002/chem.202100040
Chemistry (Weinheim an Der Bergstrasse, Germany)
Digital.CSIC. Repositorio Institucional del CSIC
instname

A facile imide coupling strategy for the one‐step preparation of G‐quadruplex ligands with varied core chemistries is described. The G‐quadruplex stabilization of a library of nine compounds was examined using FRET melting experiments, and CD,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e0fbe0813f6ae070ea58b44d3f80a0
https://doi.org/10.1002/chem.202100040

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Cellular uptake and targeting of low dispersity, dual emissive, segmented block copolymer nanofibers

Autor: Yunxiang He, Ian Manners, Steven T. G. Street, Paul Verkade, Lorna Hodgson, Xu-Hui Jin

Publikováno v: Chemical Science
Street, S T G, He, Y, Jin, X-H, Hodgson, L, Verkade, P & Manners, I 2020, ' Cellular uptake and targeting of low dispersity, dual emissive, segmented block copolymer nanofibers ', Chemical Science, vol. 11, no. 32, pp. 8394-8408 . https://doi.org/10.1039/d0sc02593c

Polymer-based nanoparticles show substantial promise in the treatment and diagnosis of cancer and other diseases. Herein we report an exploration of the cellular uptake of tailored, low dispersity segmented 1D nanoparticles which were prepared from a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa155cf5a7c1f6928cb363913bd03c7a
https://doi.org/10.1039/d0sc02593c

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