Zobrazeno 1 - 6
of 6
pro vyhledávání: '"G. Stephen Noell"'
Autor:
Ravi G. Kurumbail, Patrick Robert Verhoest, Stefanus J. Steyn, Zdenek Berger, Travis T. Wager, Bethany L. Kormos, Jayasankar Jasti, Paul Galatsis, Jaclyn Louise Henderson, Warren D. Hirst, Elie Needle, Yi Chen, Karen J. Coffman, G. Stephen Noell, Christopher Houle, Matthew Merrill Hayward
Publikováno v:
Journal of Medicinal Chemistry. 58:419-432
Leucine rich repeat kinase 2 (LRRK2) has been genetically linked to Parkinson's disease (PD) by genome-wide association studies (GWAS). The most common LRRK2 mutation, G2019S, which is relatively rare in the total population, gives rise to increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d07c27f7b39f821bc72af5c98828c6
https://doi.org/10.1021/jm5014055
https://doi.org/10.1021/jm5014055
Autor:
John Dunlop, Paul Galatsis, Kieran F. Geoghegan, Hualin Xi, Paula Loos, Greg Luerman, Chuong Nguyen, Harry Samaroo, G. Stephen Noell, Andrés Hurtado-Lorenzo, Elie Needle, Warren D. Hirst
Publikováno v:
Journal of Neurochemistry. 128:561-576
Genetic mutations in leucine-rich repeat kinase 2 (LRRK2) have been linked to autosomal dominant Parkinson's disease. The most prevalent mutation, G2019S, results in enhanced LRRK2 kinase activity that potentially contributes to the etiology of Parki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e246fffdb7d2b6338743e5fd5a4fbd7d
https://doi.org/10.1111/jnc.12483
https://doi.org/10.1111/jnc.12483
Autor:
Wendy L. Thomas, G. Stephen Noell, Mark A. Findeis, June R. Merwin, Henry C. Chiou, George L. Spitalny, Timothy D. McKee, Mary E. DeRome
Publikováno v:
Bioconjugate Chemistry. 5:612-620
In vivo gene therapy shows promise as a treatment for both genetic and acquired disorders. The hepatic asialoglycoprotein receptor (ASGPr) binds asialoorosomucoid-polylysine-DNA (ASOR-PL-DNA) complexes and allows targeted delivery to hepatocytes. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484f487c30da257b4f9d657d58b44a4c
https://doi.org/10.1021/bc00030a017
https://doi.org/10.1021/bc00030a017
Autor:
G. Stephen Noell, Maurizio Zanetti, Naomi F. Rothfield, William C. Earnshaw, Sabine Hildebrandt, Dolores Vázquez-Abad
Publikováno v:
Autoimmunity. 10:41-48
Anti-topoisomerase I autoantibodies (anti-topo I) are associated with proximal scleroderma and are of prognostic significance in patients with Raynaud's phenomenon. Polyclonal anti-idiotypic sera were raised against affinity-purified anti-topo I from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7420342c7f24b59a4e12ebd811a0a8
https://doi.org/10.3109/08916939108997146
https://doi.org/10.3109/08916939108997146
CD5-mediated specific delivery of DNA to T lymphocytes: compartmentalization augmented by adenovirus
Autor:
G. Stephen Noell, Wendy L. Thomas, Ellen P. Carmichael, Henry C. Chiou, Mary E. DeRome, June R. Merwin, Norma Robert, George L. Spitalny
Publikováno v:
Journal of immunological methods. 186(2)
Specific DNA delivery has been achieved via interactions between an asialoorosomucoid-polylysine conjugate and the asialoglycoprotein receptor. We have now extended this technology to another cell type. In order to achieve DNA delivery uniquely to T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563f8ee33cff3666b26c154443f172c6
https://pubmed.ncbi.nlm.nih.gov/7594625
https://pubmed.ncbi.nlm.nih.gov/7594625
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