Zobrazeno 1 - 10
of 936
pro vyhledávání: '"G. Stamatoyannopoulos"'
Autor:
Diana L. Browning, Jonah D. Hocum, G Stamatoyannopoulos, Grant D. Trobridge, Hongjie Wang, David J. Leap, Elizabeth M Everson
Publikováno v:
Gene therapy
Retroviral vector mediated stem cell gene therapy is a promising approach for the treatment of hematopoietic disorders. However, genotoxic side effects from integrated vector proviruses are a significant concern for the use of retroviral vectors in t
Autor:
G. Stamatoyannopoulos, B. Defaranas, G. R. Fraser, Ruth Sanger, R. R. Race, Christos Kattamis
Publikováno v:
Annals of Human Genetics. 27:395-403
Summary 1. The same recombination frequency (26 %) between the loci for G-6-PD and Xg was found in Greek populations as had been found in Israelis. Prof. Siniscalco's data from Sardinia do not agree with this frequency. 2. In four Greek populations s
Autor:
PH Fessas, C. Kitsos, D. Loukopoulos, B. Defaranas, L. Zannos-Mariolea, G. R. Fraser, G. Stamatoyannopoulos, Christos Kattamis, C. Choremis, Arno G. Motulsky
Publikováno v:
Annals of the New York Academy of Sciences. 119:415-435
Publikováno v:
Trends in Genetics. 13:61-66
Techniques are now available that allow the transfer of intact yeast artificial chromosome (YAC) DNA into transgenic mice. Coupled with the ability to perform mutagenesis on YAC sequences by homologous recombination in yeast, they enable the analysis
Publikováno v:
Blood. 83:3738-3745
A novel deletion in the human beta-globin gene cluster associated with increased levels of fetal hemoglobin (HbF) in adult life was molecularly characterized in a member of a family of Eastern European descent. The phenotype of the deletion, document
Publikováno v:
Journal of Biological Chemistry. 269:8287-8295
In order to gain further insights of the regulatory mechanisms of human beta-like globin gene switch during erythroid development, we have studied protein-DNA interaction in vivo at the human adult beta and fetal gamma globin promoters and their upst
Publikováno v:
Blood. 82:2899-2905
zeta-Globin is the embryonic form of the alpha chain of hemoglobin. Transgenic mice generated with zeta-globin constructs containing the zeta-globin gene, 557 bp of 5′ flanking sequence, and 2-kb of 3′ flanking sequence linked to the beta-globin
Autor:
K R Peterson, G Stamatoyannopoulos
Publikováno v:
Molecular and Cellular Biology. 13:4836-4843
To determine the effect of gene order on globin gene developmental regulation, we produced transgenic mice containing two tandemly arranged gamma- or beta-globin or gamma beta- and beta gamma-globin genes linked to a 2.5-kb cassette containing sequen
Autor:
P. M.S. Reddy, D. Higgs, Q Zhang, C. Y. Yu, G. Stamatoyannopoulos, T. Papayannopoulou, C. Bastiani, Che Kun James Shen
Publikováno v:
Molecular and Cellular Biology. 13:2298-2308
We studied the functional interaction between human embryonic zeta 2 globin promoter and the alpha globin regulatory element (HS-40) located 40 kb upstream of the zeta 2 globin gene. It was shown by transient expression assay that HS-40 behaved as an
Autor:
Jun-Wu Zhang, Fang-Niang Wang, G. Stamatoyannopoulos, Zhi-Ming Qiu, Guan-Yun Wu, Song-Sen Chen, Wen-Feng Song, Yan-Jun Zhao
Publikováno v:
Blood. 81:1624-1629
We have identified and molecularly characterized a novel deletion in the beta-globin gene cluster that is associated with elevated fetal hemoglobin in the adult. The propositus is a homozygote from the Yunnan province of China. The deletion spans abo