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pro vyhledávání: '"G. Somjen"'
Autor:
George G. Somjen
Ions, their transport across membranes, and their flow through specialized ion channels are central to the understanding of brain function, normal and pathological. The first part of this book deals with the regulation of ions in brain extra- and int
Autor:
G. Somjen
The articles and short communications in this volume are based on papers pre sented to the Symposium on Cerebral Hypoxia and Stroke held in Budapest in August of 1987. Besides participants at the meeting, three scientists who were invited but could
Autor:
George G. Somjen
Publikováno v:
The Neuroscientist. 8:254-267
Ions in the brain are regulated independently from plasma levels by active transport across choroid plexus epithelium and cerebral capillary endothelium, assisted by astrocytes. In “resting” brain tissue, extracellular potassium ([K+]o) is lower
Publikováno v:
Journal of Neurophysiology. 87:1924-1937
Intrinsic optical signals (IOSs) induced by synaptic stimulation and moderate hypotonic swelling in brain tissue slices consist of reduced light scattering and are usually attributed to cell swelling. During spreading depression (SD), however, light-
Autor:
George G. Somjen
Publikováno v:
Brain Research. 885:94-101
Following up on an earlier chance observation, voltage-dependent whole-cell currents were recorded from isolated hippocampal neurons filled with the fluorescent dyes Fluo-3 and Fura-red, that were intermittently excited by 488 nm laser light. In the
Publikováno v:
Journal of Neurophysiology. 84:311-324
During hypoxia in the CA1 region of the rat hippocampus, spreading-depression-like depolarization (hypoxic spreading depression or HSD) is accompanied by both a negative shift of the extracellular DC potential (DeltaV(o)), and a sharp decrease in lig
Publikováno v:
Journal of Neurophysiology. 83:81-89
Previous studies have shown that exposing hippocampal slices to low osmolarity (πo) or to low extracellular NaCl concentration ([NaCl]o) enhances synaptic transmission and also causes interstitial calcium ([Ca2+]o) to decrease. Reduction of [Ca2+]os
Publikováno v:
Methods. 18:91-103
Optical imaging techniques have the potential to bring a combination of high spatial and temporal resolution to studies of brain function. Many optical techniques require the addition of a dye or fluorescent marker to the tissue, and such methods hav
Publikováno v:
Europe PubMed Central
Largo, Carlota, Geoffrey C. Tombaugh, Peter G. Aitken, Oscar Herreras, and George G. Somjen. Heptanol but not fluoroacetate prevents the propagation of spreading depression in rat hippocampal slices. J. Neurophysiol. 77: 9–16, 1997. We investigated