Zobrazeno 1 - 10
of 57
pro vyhledávání: '"G. Sithanandam"'
Autor:
L M Anderson, G Sithanandam
Publikováno v:
Cancer Gene Therapy. 15:413-448
ERBB3, a member of the epidermal growth factor receptor (EGFR) family, is unique in that its tyrosine kinase domain is functionally defective. It is activated by neuregulins, by other ERBB and nonERBB receptors as well as by other kinases, and by nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d5bfca6cb285d037e4dddce7270f9c
https://doi.org/10.1038/cgt.2008.15
https://doi.org/10.1038/cgt.2008.15
Publikováno v:
Molecular and Cellular Biology. 12:3733-3742
B-Raf, a member of the Raf family of serine/threonine kinases, is expressed primarily in the brain and in the nervous system. In this study, the biochemical properties of the B-Raf protein were investigated in nerve growth factor (NGF)-responsive cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f80fa706a224ca109fed370b96af0ff2
https://doi.org/10.1128/mcb.12.9.3733
https://doi.org/10.1128/mcb.12.9.3733
Publikováno v:
Journal of Biological Chemistry. 266:23753-23760
Treatment of PC12 cells with nerve growth factor does not alter the levels of B-raf mRNA, but does induce rapid phosphorylation of B-raf proteins. Phosphorylation was observed after 1.5 min and reached a maximum by 10-15 min. B-raf protein was phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ccf5ef9d5fa3747892dbadc019aee05
https://doi.org/10.1016/s0021-9258(18)54347-7
https://doi.org/10.1016/s0021-9258(18)54347-7
Autor:
G. Sithanandam, A. Ashworth, C.J. Marshall, David G. Campbell, Y. Saito, U. Rapp, Philip Cohen, Sally A. Cowley, Dario R. Alessi
Publikováno v:
Europe PubMed Central
Scopus-Elsevier
Scopus-Elsevier
Many growth factors whose receptors are protein tyrosine kinases stimulate the MAP kinase pathway by activating first the GTP-binding protein Ras and then the protein kinase p74raf-1. p74raf-1 phosphorylates and activates MAP kinase kinase (MAPKK). T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a425817edc02502cdcdba4dc8a33066b
http://ora.ox.ac.uk/objects/uuid:bef492d5-b812-415e-902a-8adced3e7725
http://ora.ox.ac.uk/objects/uuid:bef492d5-b812-415e-902a-8adced3e7725
Autor:
Terry D. Copeland, Robert M. Stephens, Ulf R. Rapp, David R. Kaplan, G Sithanandam, Deborah K. Morrison
Publikováno v:
Molecular and cellular biology. 12(9)
B-Raf, a member of the Raf family of serine/threonine kinases, is expressed primarily in the brain and in the nervous system. In this study, the biochemical properties of the B-Raf protein were investigated in nerve growth factor (NGF)-responsive cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3fddc7f2046e95a94185565e5330e8
https://pubmed.ncbi.nlm.nih.gov/1508179
https://pubmed.ncbi.nlm.nih.gov/1508179
Publikováno v:
Oncogene. 7(4)
The B-raf gene was localized to human chromosome region 7p11-7qter by Southern blot analysis of its segregation in a panel of rodent-human hybrids, using a B-raf cDNA clone. Chromosomal in situ hybridization refined the localization to 7q33-36. Analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3aab1133808d64cf4d4859ada793cc9c
https://pubmed.ncbi.nlm.nih.gov/1565476
https://pubmed.ncbi.nlm.nih.gov/1565476
Publikováno v:
The Journal of biological chemistry. 266(35)
Treatment of PC12 cells with nerve growth factor does not alter the levels of B-raf mRNA, but does induce rapid phosphorylation of B-raf proteins. Phosphorylation was observed after 1.5 min and reached a maximum by 10-15 min. B-raf protein was phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22b54e4f030017ffa072be631925663d
https://pubmed.ncbi.nlm.nih.gov/1748651
https://pubmed.ncbi.nlm.nih.gov/1748651
Publikováno v:
Oncogene. 5(12)
A 2.2 kb cDNA clone which presumably includes the complete human B-raf coding sequence was isolated from a human testes cDNA library. Sequence analysis showed the presence of all three conserved regions CR1, CR2 and CR3 previously identified in raf p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::63b47b5ef9ec6eb50905959b5fcf5bad
https://pubmed.ncbi.nlm.nih.gov/2284096
https://pubmed.ncbi.nlm.nih.gov/2284096
Publikováno v:
Molecular and cellular biology. 10(7)
A genomic DNA fragment containing the Raf-1 promoter region was isolated by using a cDNA extension clone. Nucleotide sequencing of genomic DNA clones, primer extension, and S1 nuclease assays have been used to identify the 5' ends of Raf-1 RNAs. Cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2030d7fdc83a6a90f5b11094b583bd2c
https://pubmed.ncbi.nlm.nih.gov/1694010
https://pubmed.ncbi.nlm.nih.gov/1694010
Publikováno v:
Critical reviews in oncogenesis. 2(1)
There are three active raf genes in man and at least two in Xenopus and Drosophila. The mammalian c- and A-raf genes have 16 coding exons, which span 40 and 20 kb, respectively. B-raf is larger and extends over greater than 46 kb. Human c-raf-1 maps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d42d9aebabd34e49217120b68d90ca93
https://pubmed.ncbi.nlm.nih.gov/2091747
https://pubmed.ncbi.nlm.nih.gov/2091747