Zobrazeno 1 - 10
of 581
pro vyhledávání: '"G. Sims"'
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract In many diseases, misfolded proteins accumulate within the endoplasmic reticulum (ER), leading to ER stress. In response, the cell initiates the unfolded protein response (UPR) to reestablish homeostasis. Additionally, in response to ER stre
Externí odkaz:
https://doaj.org/article/3f1160e39c86495c88208f8c2c5b0938
Publikováno v:
World Journal of Orthopedics. 14:348-361
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1ef9c85df3c933739a52c601ead3fe1
https://doi.org/10.5312/wjo.v14.i5.348
https://doi.org/10.5312/wjo.v14.i5.348
Autor:
Joseph L. Costello, Christopher J. Kershaw, Lydia M. Castelli, David Talavera, William Rowe, Paul F. G. Sims, Mark P. Ashe, Christopher M. Grant, Simon J. Hubbard, Graham D. Pavitt
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-18 (2017)
Abstract Background Translation factors eIF4E and eIF4G form eIF4F, which interacts with the messenger RNA (mRNA) 5′ cap to promote ribosome recruitment and translation initiation. Variations in the association of eIF4F with individual mRNAs likely
Externí odkaz:
https://doaj.org/article/e9827a4beac84ea28a009ec11d03c0fc
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-18 (2017)
Abstract Persistent endoplasmic reticulum (ER) stress is thought to drive the pathology of many chronic disorders due to its potential to elicit aberrant inflammatory signaling and facilitate cell death. In neurodegenerative diseases, the accumulatio
Externí odkaz:
https://doaj.org/article/5ab4b0dedef049549607f178396ecd73
Autor:
Savannah G. Sims, Gordon P. Meares
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Neurodegenerative diseases are associated with the accumulation of misfolded proteins in the endoplasmic reticulum (ER), leading to ER stress. To adapt, cells initiate the unfolded protein response (UPR). However, severe or unresolved UPR activation
Externí odkaz:
https://doaj.org/article/1ee6647be84b4fd2b1f2c2e4ee693925
Publikováno v:
Journal of Orthopaedic Case Reports. 12:31-34
Background: Diagnostic dilemma exists in differentiating between neck and shoulder pathology, as both can give a rise to shoulder and arm symptoms. In addition, the hypersensitivity of magnetic resonance imaging (MRI) scans may wrongly highlight non-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e6ce58a8569638cdaa1aeae5eb4f7d3
https://doi.org/10.13107/jocr.2022.v12.i04.2754
https://doi.org/10.13107/jocr.2022.v12.i04.2754
Publikováno v:
Journal of Surgical Case Reports. 2022
Failed back surgery syndrome is defined as increased or persistent pain following spinal surgery. Despite a relatively high incidence of failed back surgery syndrome (20%), patients may not be counselled regarding this complication pre-operatively. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fff6b52f386c0be47f49cbfa37dbdfe
https://doi.org/10.1093/jscr/rjac431
https://doi.org/10.1093/jscr/rjac431
Publikováno v:
World journal of orthopedics. 13(7)
Evidence regarding the effectiveness of using orthotics in improving comfort, increasing running speed and helping to reduce injury rate during running is limited and mixed. Alongside the increasing popularity of running is the increasing rate of run
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc027264a28feaa4e0ef50b40d4327b
https://pubmed.ncbi.nlm.nih.gov/36051374
https://pubmed.ncbi.nlm.nih.gov/36051374
Autor:
Lydia M Castelli, David Talavera, Christopher J Kershaw, Sarah S Mohammad-Qureshi, Joseph L Costello, William Rowe, Paul F G Sims, Christopher M Grant, Simon J Hubbard, Mark P Ashe, Graham D Pavitt
Publikováno v:
PLoS Genetics, Vol 11, Iss 5, p e1005233 (2015)
Translation initiation factor eIF4E mediates mRNA selection for protein synthesis via the mRNA 5'cap. A family of binding proteins, termed the 4E-BPs, interact with eIF4E to hinder ribosome recruitment. Mechanisms underlying mRNA specificity for 4E-B
Externí odkaz:
https://doaj.org/article/4442571fc9da4cb6b3f3487cf8c78944