Zobrazeno 1 - 10
of 17
pro vyhledávání: '"G. Scott Chandler"'
Autor:
Zia Khan, Min Jung, Megan Crow, Rajat Mohindra, Vidya Maiya, Joshua S. Kaminker, David H. Hackos, G. Scott Chandler, Mark I. McCarthy, Tushar Bhangale
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-15 (2023)
Abstract Background Dose-limiting toxicities significantly impact the benefit/risk profile of many drugs. Whole genome sequencing (WGS) in patients receiving drugs with dose-limiting toxicities can identify therapeutic hypotheses to prevent these tox
Externí odkaz:
https://doaj.org/article/8203af64f2254efdb0211f8800973199
Autor:
Katrin Madjar, Rajat Mohindra, Gonzalo Durán-Pacheco, Rashad Rasul, Laurent Essioux, Vidya Maiya, G. Scott Chandler
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundImmune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer patients in the last decade, but immune-related adverse events (irAEs) pose significant clinical challenges. Despite advances in the management of these unique
Externí odkaz:
https://doaj.org/article/3908e581aa5f492fbf36449ebc775e8e
Autor:
Zia Khan, Christian Hammer, Jonathan Carroll, Flavia Di Nucci, Sergio Ley Acosta, Vidya Maiya, Tushar Bhangale, Julie Hunkapiller, Ira Mellman, Matthew L. Albert, Mark I. McCarthy, G. Scott Chandler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Endocrinopathies, such as thyroid autoimmunity, are common among patients treated with immune checkpoint inhibitors. Here, by using a polygenic risk score (PRS) derived from a hypothyroidism GWAS, the authors show that cancer patients with high PRS a
Externí odkaz:
https://doaj.org/article/c4d618dc88c448e799c4accf705c951a
Autor:
Christine Spencer, Shahneen Sandhu, Ira Mellman, Zia Khan, Julie Hunkapiller, Samantha Bucktrout, Ashis Saha, Jonathan Carroll, Claudia Yanez Arellano, Nicholas Bayless, Leonardo Nissola, Roslyn Wallace, Rajat Mohindra, G. Scott Chandler, Christian Hammer
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/629d7e62efc34dd9a228dc2109fa9d0c
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-3 (2019)
Editorial summary Personalized care of cancer patients undergoing treatment with immune checkpoint inhibitors will require approaches that can predict their susceptibility to immune-related adverse events. Understanding the role of germline genetic f
Externí odkaz:
https://doaj.org/article/4d49831177724f52b00d797b5b844e36
Autor:
David Roe, Ira Mellman, Mark McCarthy, Ashis Saha, Rajat Mohindra, Christian Hammer, Cameron Adams, G Scott Chandler
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/a9ad185c44b745b893e6606efca62005
Autor:
Thomas Powles, Sanjeev Mariathasan, Rajat Mohindra, G Scott Chandler, Corey Carter, Katrin Madjar, Bogdana I Balas, Laurent Essioux, Viraj Degaonkar
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/bb878d74a8b546d89c2326fb092c5031
Autor:
David Roe, Howard Rosoff, Dan Fu Ruan, Zia Khan, Pranay Dogra, Jonathan Carroll, Julie Hunkapiller, Rajat Mohindra, Minu K. Srivastava, Barzin Y. Nabet, G. Scott Chandler, Matthew L. Albert, Mark I. McCarthy, Ira Mellman, Amir Horowitz, Christian Hammer
Natural killer (NK) cells are educated through the binding of killer immunoglobulin like receptors (KIR) to human leukocyte antigen (HLA) proteins, but it is unknown whether the presence of these highly diverse KIR/HLA interactions influence response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b773af8f060a1dc565a7958fea1a593b
https://doi.org/10.1101/2022.12.06.22282592
https://doi.org/10.1101/2022.12.06.22282592
Autor:
Hannah Barman, Sriram Venkateswaran, Antonio Del Santo, Krishna Rao, Bharathwaj Raghunatha, Unice Yoo, Lisa Kottschade, Matthew Block, G Scott Chandler, Tyler Wagner, Rajat Mohindra
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Zia Khan, Min Jung, Megan Crow, Rajat Mohindra, Vidya Maiya, Joshua Kaminker, David Hackos, G. Scott Chandler, Mark McCarthy, Tushar Bhangale
Dose-limiting toxicities significantly impact the benefit/risk profile of many drugs. Whole genome sequencing (WGS) in patients receiving drugs with dose-limiting toxicities can identify therapeutic hypotheses to prevent these toxicities. Peripheral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::475494e22eba51cbe498b2e4669edc38
https://doi.org/10.21203/rs.3.rs-1816977/v1
https://doi.org/10.21203/rs.3.rs-1816977/v1