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Akademický článek

Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes

Autor: Ahmed El‐Boraie, Julie‐Anne Tanner, Andy Z.X. Zhu, Katrina G. Claw, Bhagwat Prasad, Erin G. Schuetz, Kenneth E. Thummel, Koya Fukunaga, Taisei Mushiroda, Michiaki Kubo, Neal L. Benowitz, Caryn Lerman, Rachel F. Tyndale

Publikováno v: Clinical and Translational Science, Vol 15, Iss 1, Pp 204-220 (2022)

Abstract CYP2A6 activity, phenotyped by the nicotine metabolite ratio (NMR), is a predictor of several smoking behaviors, including cessation and smoking‐related disease risk. The heritability of the NMR is 60–80%, yet weighted genetic risk score

Externí odkaz: https://doaj.org/article/227fec3dc8d24dc2934491cf383a5b28

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Akademický článek

Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities, targeting CYP3A4*1G allele function

Autor: Alison E. Fohner, Rachel Dalton, Kasse Skagen, Konner Jackson, Katrina G. Claw, Scarlett E. Hopkins, Renee Robinson, Burhan A. Khan, Bhagwat Prasad, Erin G. Schuetz, Deborah A. Nickerson, Timothy A. Thornton, Denise A. Dillard, Bert B. Boyer, Kenneth E. Thummel, Erica L. Woodahl

Publikováno v: Clinical and Translational Science, Vol 14, Iss 4, Pp 1292-1302 (2021)

Abstract The frequencies of genetic variants in the CYP3A4 and CYP3A5 genes differ greatly across global populations, leading to profound differences in the metabolic activity of these enzymes and resulting drug metabolism rates, with important conse

Externí odkaz: https://doaj.org/article/18c815b78eaf46c482f67ddc2280dfe6

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Akademický článek

Tracking the cultural niches of North American birds through time

Autor: Justin G. Schuetz, Alison Johnston

Publikováno v: People and Nature, Vol 3, Iss 1, Pp 251-260 (2021)

Abstract Conservation efforts are constrained by our poor grasp of changing relationships between humans and other species. We used internet query data describing relative public interest in different species of birds, and combined them with citizen

Externí odkaz: https://doaj.org/article/e30b8e22920749b7ac48aec5b02b567f

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Akademický článek

Vitamin D levels do not cause vitamin-drug interactions with dexamethasone or dasatinib in mice

Autor: Kavya Annu, Kazuto Yasuda, William V. Caufield, Burgess B. Freeman, Erin G. Schuetz

Publikováno v: PLoS ONE, Vol 16, Iss 10 (2021)

Vitamin D3 (VD3) induces intestinal CYP3A that metabolizes orally administered anti-leukemic chemotherapeutic substrates dexamethasone (DEX) and dasatinib potentially causing a vitamin-drug interaction. To determine the impact of VD3 status on system

Externí odkaz: https://doaj.org/article/70d4271398e1490ea4a69f7b7d98a340

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Akademický článek

Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters.

Autor: Samit Ganguly, David Finkelstein, Timothy I Shaw, Ryan D Michalek, Kimberly M Zorn, Sean Ekins, Kazuto Yasuda, Yu Fukuda, John D Schuetz, Kamalika Mukherjee, Erin G Schuetz

Publikováno v: PLoS ONE, Vol 16, Iss 7, p e0253852 (2021)

Abcg2/Bcrp and Abcb1a/Pgp are xenobiotic efflux transporters limiting substrate permeability in the gastrointestinal system and brain, and increasing renal and hepatic drug clearance. The systemic impact of Bcrp and Pgp ablation on metabolic homeosta

Externí odkaz: https://doaj.org/article/b18f9e558107487fa2603259aa77bcbd

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