Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

Autor: Tue Tb Bennike, Tobias R. Kollmann, Alansana Darboe, Peter Richmond, Hanno Steen, Ofer Levy, Asimenia Angelidou, Mehrnoush Malek, Casey P. Shannon, Daniel He, Anita Ahj van den Biggelaar, Guzman Sanchez-Schmitz, Ahwon Lee, Cai Bing, Elishia Roberts, Kim-Anh Lê Cao, Jorjoh Ndure, Joann Diray-Arce, Davide Ferrari, Reza Falsafi, Jainaba Njie-Jobe, Kinga K. Smolen, Momoudou Cox, Geraldine Masiria, William Ws Pomat, Rym Ben-Othman, Amrit Singh, Ryan Rr Brinkman, Erin E. Gill, John Paul Matlam, Scott Sj Tebbutt, Nelly Amenyogbe, Samuel Sj Hinshaw, Rebecca Ford, Robert E. W. Hancock, Daniel Dj Harbeson, G Saleu, Simon Sd van Haren, Matthew Ma Pettengill, Al Ozonoff, Olubukola Ot Idoko, Beate Kampmann, Wendy Kirarock

Publikováno v: Lee, A H, Shannon, C P, Amenyogbe, N, Bennike, T B, Diray-Arce, J, Idoko, O T, Gill, E E, Ben-Othman, R, Pomat, W S, van Haren, S D, Cao, K A L, Cox, M, Darboe, A, Falsafi, R, Ferrari, D, Harbeson, D J, He, D, Bing, C, Hinshaw, S J, Ndure, J, Njie-Jobe, J, Pettengill, M A, Richmond, P C, Ford, R, Saleu, G, Masiria, G, Matlam, J P, Kirarock, W, Roberts, E, Malek, M, Sanchez-Schmitz, G, Singh, A, Angelidou, A, Smolen, K K, The EPIC Consortium, Brinkman, R R, Ozonoff, A, Hancock, R E W, van den Biggelaar, A H J, Steen, H, Tebbutt, S J, Kampmann, B, Levy, O & Kollmann, T R 2019, ' Dynamic molecular changes during the first week of human life follow a robust developmental trajectory ', Nature Communications, vol. 10, no. 1, 1092 . https://doi.org/10.1038/s41467-019-08794-x
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature communications, 10 (1

Systems biology can unravel complex biology but has not been extensively applied to human newborns, a group highly vulnerable to a wide range of diseases. We optimized methods to extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2932549b71532d1598206a46d8ed0bad
https://vbn.aau.dk/da/publications/a883a18f-2630-4edf-a9b4-aa008fca0d0c

Pneumococcal responses are similar in Papua New Guinean children aged 3-5 years vaccinated in infancy with pneumococcal polysaccharide vaccine with or without prior pneumococcal conjugate vaccine, or without pneumococcal vaccination

Autor: Angela Fuery, Jacinta Francis, Deborah Lehmann, Mildred Lai, Anita H. J. van den Biggelaar, Christine Opa, Peter Richmond, Denise Anderson, G Saleu, William Pomat, Michael P. Alpers

Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0185877 (2017)
PLoS ONE

Trial design In an earlier trial, Papua New Guinean (PNG) children at high risk of pneumococcal disease were randomized to receive 0 or 3 doses of 7-valent pneumococcal conjugate vaccine (PCV7), followed by a single dose of 23-valent pneumococcal pol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42767967f5fd9a1d515c3ee9b27e1fa
https://doi.org/10.1371/journal.pone.0185877

Bacterial, viral and parasitic aetiology of paediatric diarrhoea in the highlands of Papua New Guinea

Autor: A Javati, S Lupiwa, A Atkinson, M Mens, Michael P. Alpers, Neal Alexander, B. West, Peter Howard, A. Clegg, R. C. Sanders, T Lupiwa, G Saleu, G Gerega, M. Kajoi

Publikováno v: Journal of Tropical Pediatrics. 46:10-14

Enteropathogens and clinical features associated with diarrhoea were investigated in 1526 children admitted over a 5-year period to the paediatric ward of a hospital in the highlands of Papua New Guinea. Overall, a recognized pathogen was isolated fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6aba4549645c4f1ab04eb4c06ab57d9
https://doi.org/10.1093/tropej/46.1.10

Bacterial and viral etiology of severe infection in children less than three months old in the highlands of Papua New Guinea

Autor: D Lewis, D. Lehmann, G Saleu, P Namuigi, A. Clegg, A Rongap, B Marjen, P Wai'in, M Omena, Audrey Michael, R. C. Sanders, Michael P. Alpers, M Kakazo, T Lupiwa, S Lupiwa

Publikováno v: The Pediatric Infectious Disease Journal. 18:S42-S49

Objective. Determine the bacterial and viral etiology of severe infection in young Papua New Guinean infants as part of a multicenter study in four developing countries aimed at improving case management guidelines. Methods. Between March, 1991, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e5aabd2560a41c760ed3bffa67a875
https://doi.org/10.1097/00006454-199910001-00008

Bacterial etiology of serious infections in young infants in developing countries: results of a multicenter study

Autor: M Sungu, John B. Carlin, Martin W. Weber, L Sombrero, F McCaul, R Facklam, F Palladin, K Woldeyesus, M Omena, P Wai'in, G Cassell, M Hendry, L Moore, F Harrell, AM Moreles, D Hazlett, A Rongap, Salvacion Gatchalian, A. Palmer, C Broome, B Belete, S Kebede, M Kakazo, Michael P. Alpers, A Yohanes, J Schachter, M Gratten, Audrey Michael, Peter Byass, H Eichenwald, Mark J. Manary, S Ringertz, S Parker, A Clegg, B Metchock, AM Obach, Ousman Secka, P Margolis, Brian Greenwood, M Grandien, T Desta, K Mulholland, S Lupiwa, V Sariano, L Abraham, K Mason, M Aidoo, H Tschappeler, Terry Nolan, F Tenover, P Namuigi, D. Lehmann, M Tilahun, B Marjen, J Hendrichsen, L Muhe, E Sunico, PH Makela, Richard A. Adegbola, P Palmer, Hilton Whittle, R Sehuko, R. C. Sanders, D Lewis, B Quiambao, S Gove, B Sam, A Lament, S Lulseged, O Ogunlesi, T Lupiwa, N Tafari, M Mens, G Saleu, T Cedulla, C John, J Bangali, L Duffy

Publikováno v: The Pediatric Infectious Disease Journal. 18:S17-S22

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28c9d46d1700108337b229fcd8ea2d76
https://doi.org/10.1097/00006454-199910001-00004