Zobrazeno 1 - 10
of 11
pro vyhledávání: '"G. S. Sach"'
Autor:
David J. Watkin, Keith Prout, G. J. Durant, D. G. Cooper, Ch R Ganellin, K. Burns, G. S. Sach
Publikováno v:
Acta Crystallographica Section B Structural Science. 49:547-559
The crystal and molecular structures of the following compounds showing histamine H2-antagonist activity have been determined: (1) N-Cyano-N'-methyl-N"-12[(2-pyridyl)methylthi_'o]ethyl } guanidine, C 11H 15 N5 S, Mr = 249.33, triclinic, P1, a = 7.482
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cd0f8d47f2e75a28e25c8a162f6bdb7
https://doi.org/10.1107/s0108768193000217
https://doi.org/10.1107/s0108768193000217
Autor:
Ch R Ganellin, K. Burns, D. G. Cooper, David J. Watkin, G. J. Durant, G. S. Sach, C. Bannister, Robert J. Ife, Keith Prout
Publikováno v:
Acta crystallographica. Section B, Structural science. 50
The crystal and molecular structures of ten compounds with strong structural resemblances to the cimetidine group of histamine H2-receptor antagonists, but exhibiting selective H1-receptor antagonist activity, (1)-(7), or H1 and H2 activity (8)-(10),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485396c1eadca30fd9ca50b33d1a7a4c
https://pubmed.ncbi.nlm.nih.gov/7911673
https://pubmed.ncbi.nlm.nih.gov/7911673
Publikováno v:
Farmaco (Societa chimica italiana : 1989). 46(1)
For a series of 2-(pyridin-2-ylbutylamino)-5-(3-picolinylmethyl)pyrimidin- 4(1H)-ones (isocytosines) substituted in the pyridine 3-position, activity as H1- and H2-receptor histamine antagonists appears to correlate with the size of the 3-substituent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6068ef722f226289500af1e1831a74d4
https://pubmed.ncbi.nlm.nih.gov/1675853
https://pubmed.ncbi.nlm.nih.gov/1675853
Publikováno v:
Experientia. 33:198-200
A series of nitrothiophene compounds, with activity against Schistosoma mansoni in mice, is described and shown to be more effective than the corresponding nitrofurans.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb764dfdac62e6a1109494ab7ca005a1
https://doi.org/10.1007/bf02124064
https://doi.org/10.1007/bf02124064
Autor:
Robert Blakemore, G. J. Durant, D. A. A. Owen, Charon R. Ganellin, Thomas Henry Brown, C. A. Harvey, Michael E. Parsons, A. C. Rasmussen, G. S. Sach, D. G. Cooper, Robert John Ife
Publikováno v:
New England and regional allergy proceedings. 7(2)
SK&F 93319 (icotidine), 2-[4-(3-methoxypyrid-2-yl)butylamino]-5-[(6-methylpyrid-3-yl )-methyl]- pyrimidin-4-one trihydrochloride, has been identified as a novel agent which combines into one molecule the ability to antagonize the actions of histamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88f0db1dfcc7af2e675f402979a61ef
https://pubmed.ncbi.nlm.nih.gov/2886901
https://pubmed.ncbi.nlm.nih.gov/2886901
Publikováno v:
Chemischer Informationsdienst. Organische Chemie. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8509832b08e643adbe513b6f90391cba
https://doi.org/10.1002/chin.197122305
https://doi.org/10.1002/chin.197122305
Publikováno v:
Journal of the American Chemical Society. 87:676-677
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b349df71786b16c6436341e9743c853a
https://doi.org/10.1021/ja01081a065
https://doi.org/10.1021/ja01081a065
Publikováno v:
Journal of the Chemical Society C: Organic. :487
2-Ethyl-2-devinylprotoporphyrin-IX dimethyl ester has been synthesised by the a-oxobilane route, the 4-vinyl group being introduced by a new method, viz. transformation of a β-acetoxyethyl side-chain present in one of the intermediate pyrroles. Prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d78c66b117b1a976eeb141dc57f64b7
https://doi.org/10.1039/j39710000487
https://doi.org/10.1039/j39710000487
Publikováno v:
Journal of the Chemical Society (Resumed). :578
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d28244cc938d27388dffbae02bd7e035
https://doi.org/10.1039/jr9640000578
https://doi.org/10.1039/jr9640000578
Publikováno v:
Journal of the Chemical Society (Resumed). :4458
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef48e8c9945017397eecb82c59f69095
https://doi.org/10.1039/jr9580004458
https://doi.org/10.1039/jr9580004458