Zobrazeno 1 - 10
of 47
pro vyhledávání: '"G. S. Bova"'
Autor:
D. J. Woodcock, E. Riabchenko, S. Taavitsainen, M. Kankainen, G. Gundem, D. S. Brewer, P. Ellonen, M. Lepistö, Y. A. Golubeva, A. C. Warner, T. Tolonen, J. Jasu, W. B. Isaacs, M. R. Emmert-Buck, M. Nykter, T. Visakorpi, G. S. Bova, D. C. Wedge
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The evolutionary progression from primary to metastatic prostate cancer is largely uncharted, and the implications for liquid biopsy are unexplored. Here, the authors use deep genomic sequencing and histopathological information to trace tumor evolut
Externí odkaz:
https://doaj.org/article/6ef5ee7977814b898210580b5f7363d6
Autor:
Pekka Ellonen, Ekaterina Riabchenko, David C. Wedge, Y. A. Golubeva, Daniel Brewer, Matti Kankainen, Michael R. Emmert-Buck, Tapio Visakorpi, A. C. Warner, Maija Lepistö, J. Jasu, G. S. Bova, Dan J. Woodcock, Teemu Tolonen, William B. Isaacs, Matti Nykter, Sinja Taavitsainen, Gunes Gundem
Publikováno v:
Woodcock, D J, Riabchenko, E, Taavitsainen, S, Kankainen, M, Gundem, G, Brewer, D S, Ellonen, P, Lepistö, M, Golubeva, Y A, Warner, A C, Tolonen, T, Jasu, J, Isaacs, W B, Emmert-buck, M R, Nykter, M, Visakorpi, T, Bova, G S & Wedge, D C 2020, ' Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy ', Nature Communications, vol. 11, no. 1 . https://doi.org/10.1038/s41467-020-18843-5
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
The evolutionary progression from primary to metastatic prostate cancer is largely uncharted, and the implications for liquid biopsy are unexplored. We infer detailed reconstructions of tumor phylogenies in ten prostate cancer patients with fatal dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6788ffdd1cdb193b40d7588db221f973
http://www.nature.com/articles/s41467-020-18843-5
http://www.nature.com/articles/s41467-020-18843-5
Autor:
H. Urhonen, T. Visakorpi, H. Rauhala, Matti Nykter, J. Kesseli, Leena Latonen, A. Kohvakka, M. Sattari, G S Bova, E. Moradi
Publikováno v:
European Urology Supplements. 18:e3078
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec078de8b57f58e83b59f010ed9afe64
https://doi.org/10.1016/s1569-9056(19)33325-1
https://doi.org/10.1016/s1569-9056(19)33325-1
Autor:
Charles M. Ewing, Seong Tae Kim, Junjie Feng, Y. Yan, Jishan Sun, Zheng Zhang, Zhong Wang, Guangchao Sui, Lars Egevad, Siqun Zheng, Meimei Wan, Jun Luo, Jianfeng Xu, Robert L. Vessella, Scott D. Cramer, Tao Li, Guifang Yan, Chunmei C. Xie, Marta Gielzak, G. S. Bova, Wennuan Liu, Aubrey R. Turner, W. Isaacs, Henrik Grönberg, Johan Lindberg
Publikováno v:
Oncogene. 31:3939-3948
A clearer definition of the molecular determinants that drive the development and progression of prostate cancer (PCa) is urgently needed. Efforts to map recurrent somatic deletions in the tumor genome, especially homozygous deletions (HODs), have pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5b374b932b940fcb1a1d05d386d5a6
https://doi.org/10.1038/onc.2011.554
https://doi.org/10.1038/onc.2011.554
Publikováno v:
The Journal of Urology. :512-516
Under normal conditions genomic CpG islands are not methylated. Hypermethylation of a CpG island in the 5' regulatory region of a gene has the capacity to silence gene transcription. Recently, hypermethylation of a CpG island at D17S5 on chromosome 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d015ff3ed2a84c000bda97e4936d2728
https://doi.org/10.1097/00005392-199608000-00073
https://doi.org/10.1097/00005392-199608000-00073
Publikováno v:
The Prostate. 29:36-44
Molecular biologic studies have now identified a number of important genetic and epigenetic mechanisms that cause alterations in growth and differentiation genes in prostate cancer. In addition to DNA deletion and point mutation, DNA methylation repr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c8f679c80a7fe0912ea0daf5004320a
https://doi.org/10.1002/(sici)1097-0045(1996)6+<36::aid-pros8>3.0.co
https://doi.org/10.1002/(sici)1097-0045(1996)6+<36::aid-pros8>3.0.co
Autor:
T. Visakorpi, Hans Lilja, Johanna Schleutker, T. Wahlfors, K. Leinonen, Outi R. Saramäki, Teuvo L.J. Tammela, Janika Nättinen, Matti Nykter, L Sjöblom, G S Bova, T. Tolonen, Matti Annala
Publikováno v:
European Urology Supplements. 15:e1074
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c3789929ff855a3ab7397a12b965b00
https://doi.org/10.1016/s1569-9056(16)61075-8
https://doi.org/10.1016/s1569-9056(16)61075-8
Autor:
G S Bova, Marion J. G. Bussemakers, Charles M. Ewing, William B. Isaacs, James D. Brooks, Ronald A. Morton
Publikováno v:
Cold Spring Harbor Symposia on Quantitative Biology. 59:653-659
A number of genetic changes have been documented in prostate cancer, ranging from allelic loss to point mutations and changes in DNA methylation patterns (summarized in Fig. 1). To date, the most consistent changes are those of allelic loss events, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9668ae8ec1f5f90edbe64941dfcd26ab
https://doi.org/10.1101/sqb.1994.059.01.075
https://doi.org/10.1101/sqb.1994.059.01.075
Autor:
Gunes Gundem, David C. Wedge, Elli Papaemmanuil, Kevin J. Dawson, David E. Neal, Michael R. Emmert-Buck, Matti Annala, Hayley C. Whitaker, Calli Latimer, Victoria Goody, Sarah O’Meara, Douglas F. Easton, Ludmil B. Alexandrov, Rosalind A. Eeles, Gunilla Högnäs, Kati Kivinummi, Jose M. C. Tubio, Ultan McDermott, Barbara Kremeyer, Peter Van Loo, Christopher S. Foster, Matti Nykter, William B. Isaacs, Tapio Visakorpi, Zsofia Kote-Jarai, Peter J. Campbell, Colin Cooper, G. S. Bova, Daniel Brewer, Heini Kallio
Publikováno v:
Cancer Research. 75:956-956
Cancers emerge from an on-going Darwinian evolutionary process, often leading to multiple competing subclones within a single primary tumour. This evolutionary process culminates in the formation of metastases, which is the cause of 90% of cancer-rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::269647acecb6cdd6f76d570663a83145
https://doi.org/10.1158/1538-7445.am2015-956
https://doi.org/10.1158/1538-7445.am2015-956