Zobrazeno 1 - 10
of 1 796
pro vyhledávání: '"G. Rosenfeld"'
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 4, Pp 772-787 (2024)
Abstract Although often located at a distance from their target gene promoters, enhancers are the primary genomic determinants of temporal and spatial transcriptional specificity in metazoans. Since the discovery of the first enhancer element in simi
Externí odkaz:
https://doaj.org/article/b25ed807a93a4fb98861d6651c9d6d44
Publikováno v:
Siberian Journal of Life Sciences and Agriculture, Vol 14, Iss 3, Pp 143-153 (2022)
Increasing the biological and nutritional value of breast milk substitutes by enriching different macro- and micronutrients is an important issue. To a certain extent, the nutritional value of milk is determined by its antioxidant activity. The res
Externí odkaz:
https://doaj.org/article/0a43be572fd447d7819aa29daca31610
Publikováno v:
Online Journal of Rural Nursing and Health Care, Vol 20, Iss 2, Pp 78-107 (2020)
Purpose: Self-care is an essential component of secondary prevention of coronary artery disease (CAD) for rural women after undergoing invasive coronary interventions (ICI). The purpose of the study was to describe self-care behavior experiences of r
Externí odkaz:
https://doaj.org/article/5821da1993d44d549d0b9c9fc0f0220d
Autor:
Nicholas K. Vinckier, Nisha A. Patel, Ryan J. Geusz, Allen Wang, Jinzhao Wang, Ileana Matta, Austin R. Harrington, Matthew Wortham, Nichole Wetton, Jianxun Wang, Ulupi S. Jhala, Michael G. Rosenfeld, Christopher W. Benner, Hung-Ping Shih, Maike Sander
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
How epigenetic regulation affects pancreatic development is unclear. Here, the authors show that the histone demethylase LSD1 regulates the epigenetic state of developmental enhancers during pancreatic specification and controls how these enhancers r
Externí odkaz:
https://doaj.org/article/219e2bb5225f43dcb77d228c096f4de8
Autor:
Hai‐feng Shen, Wen‐juan Zhang, Ying Huang, Yao‐hui He, Guo‐sheng Hu, Lei Wang, Bing‐ling Peng, Jia Yi, Ting‐ting Li, Rui Rong, Xiao‐yan Chen, Jun‐yi Liu, Wen‐juan Li, Kenny Ohgi, Shao‐Wei Li, Michael G. Rosenfeld, Wen Liu
Publikováno v:
Advanced Science, Vol 8, Iss 9, Pp n/a-n/a (2021)
Abstract Emerging evidence suggested that epigenetic regulators can exhibit both activator and repressor activities in gene transcriptional regulation and disease development, such as cancer. However, how these dual activities are regulated and coord
Externí odkaz:
https://doaj.org/article/ec880b50ff614bc8a1c441bf0a205ceb
Autor:
Seung-Soo Kim, Adam D Hudgins, Jiping Yang, Yizhou Zhu, Zhidong Tu, Michael G Rosenfeld, Teresa P DiLorenzo, Yousin Suh
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257265 (2021)
Type 1 diabetes (T1D) is an organ-specific autoimmune disease, whereby immune cell-mediated killing leads to loss of the insulin-producing β cells in the pancreas. Genome-wide association studies (GWAS) have identified over 200 genetic variants asso
Externí odkaz:
https://doaj.org/article/ef6473d563c743d89291adf7966b5f00
Autor:
Yuliang Tan, Lu Yao, Amir Gamliel, Sreejith J. Nair, Havilah Taylor, Kenny Ohgi, Aneel K. Aggarwal, Michael G. Rosenfeld
Publikováno v:
Nature structural & molecular biology, vol 30, iss 2
Enhancer activation serves as the main mechanism regulating signal-dependent transcriptional programs, ensuring cellular plasticity, yet central questions persist regarding their mechanism of activation. Here, by successfully mapping topoisomerase I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b5f81fae90789670794094cb8cc3681
https://doi.org/10.1038/s41594-022-00883-8
https://doi.org/10.1038/s41594-022-00883-8
Autor:
Zhengyu Luo, Xiaorong Wang, Hong Jiang, Ruoyu Wang, Jian Chen, Yusheng Chen, Qianlan Xu, Jun Cao, Xiaowen Gong, Ji Wu, Yungui Yang, Wenbo Li, Chunsheng Han, C. Yan Cheng, Michael G. Rosenfeld, Fei Sun, Xiaoyuan Song
Publikováno v:
iScience, Vol 23, Iss 4, Pp - (2020)
Summary: Three-dimensional chromatin structures undergo dynamic reorganization during mammalian spermatogenesis; however, their impacts on gene regulation remain unclear. Here, we focused on understanding the structure-function regulation of meiotic
Externí odkaz:
https://doaj.org/article/72a3812777ad4f4483c16dabaca76593
Autor:
Werner F. Blum, Jürgen Klammt, Serge Amselem, Heike M. Pfäffle, Marie Legendre, Marie-Laure Sobrier, Marie-Pierre Luton, Christopher J. Child, Christine Jones, Alan G. Zimmermann, Charmian A. Quigley, Gordon B. Cutler, Jr, Cheri L. Deal, Jan Lebl, Ron G. Rosenfeld, John S. Parks, Roland W. Pfäffle
Publikováno v:
EBioMedicine, Vol 36, Iss , Pp 390-400 (2018)
Background: Pituitary development and GH secretion are orchestrated by multiple genes including GH1, GHRHR, GLI2, HESX1, LHX3, LHX4, PROP1, POU1F1, and SOX3. We aimed to assess their mutation frequency and clinical relevance in children with severe G
Externí odkaz:
https://doaj.org/article/eb38d45a2af84fb1a420e9f01ae4ca4c
Autor:
Jürgen Klammt, David Neumann, Evelien F. Gevers, Shayne F. Andrew, I. David Schwartz, Denise Rockstroh, Roberto Colombo, Marco A. Sanchez, Doris Vokurkova, Julia Kowalczyk, Louise A. Metherell, Ron G. Rosenfeld, Roland Pfäffle, Mehul T. Dattani, Andrew Dauber, Vivian Hwa
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Severe growth hormone insensitivity syndrome (GHIS) with immunodeficiency is caused by autosomal recessive mutations in STAT5B. Here the authors report heterozygous STAT5B mutations with dominant-negative effects, causing mild GHIS without immune def
Externí odkaz:
https://doaj.org/article/2f6935ea40d3432bb5ef0a1b2cc1c995