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Parallel single-cell and bulk transcriptome analyses reveal key features of the gastric tumor microenvironment

Autor: Boxi Kang, Jordi Camps, Biao Fan, Hongpeng Jiang, Mahmoud M. Ibrahim, Xueda Hu, Shishang Qin, Dennis Kirchhoff, Derek Y. Chiang, Shan Wang, Yingjiang Ye, Zhanlong Shen, Zhaode Bu, Zemin Zhang, Helge G. Roider

Publikováno v: Genome Biology, Vol 23, Iss 1, Pp 1-25 (2022)

Abstract Background The tumor microenvironment (TME) has been shown to strongly influence treatment outcome for cancer patients in various indications and to influence the overall survival. However, the cells forming the TME in gastric cancer have no

Externí odkaz: https://doaj.org/article/f607a81be80f4944938163ec4f1a798d

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Data from Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2)

Autor: Lars Roese, Bertolt Kreft, Ilan Vaknin, Gady Cojocaru, Inbal Barbiro, Meir Azulay, Ofer Levy, Zurit Levine, Andrew Drake, Andrew Pow, John Hunter, Anna-Lena Frisk, Helge G. Roider, Sven Golfier, Merlin V. Luetke-Eversloh, Wolf-Dietrich Doecke, Ilona Gutcher, Uwe Gritzan, Julia Huetter

The immunoglobulin-like domain containing receptor 2 (ILDR2), a type I transmembrane protein belonging to the B7 family of immunomodulatory receptors, has been described to induce an immunosuppressive effect on T-cell responses. Besides its expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2144ef0b970d839bedb826181349a4
https://doi.org/10.1158/2326-6066.c.6550420

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Table S5 from Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2)

Histopathological findings in 8 weeks and 12 months old wild-type and ILDR2-deficient C57BL/6mice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31629b8fe14b92073615c99892180cf9
https://doi.org/10.1158/2326-6066.22543822

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Supplementary Information from Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2)

Supplementary information

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17fe2a0db33965d3dfc6aa1526012afa
https://doi.org/10.1158/2326-6066.22543837.v1

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Figures S1-S8 from Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2)

Supplementary figures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f95813e0e502ffeed2631cf6adb8dc7
https://doi.org/10.1158/2326-6066.22543840.v1

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Data from Meta-Analysis of Human Cancer Single-Cell RNA-Seq Datasets Using the IMMUcan Database

Autor: Vassili Soumelis, Helge G. Roider, Jasna Medvedovic, Jack Pollard, Mahmoud M. Ibrahim, Melissa Saichi, Elise Amblard, Caroline Hoffmann, Lou Götz, Sidwell Rigade, Lucile Massenet-Regad, Robin Liechti, Floriane Noël, Jordi Camps

The development of single-cell RNA sequencing (scRNA-seq) technologies has greatly contributed to deciphering the tumor microenvironment (TME). An enormous amount of independent scRNA-seq studies have been published representing a valuable resource t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d986d1a119136bbee5ab979ce061c8
https://doi.org/10.1158/0008-5472.c.6514194.v1

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Supplementary Data from Meta-Analysis of Human Cancer Single-Cell RNA-Seq Datasets Using the IMMUcan Database

Supplementary Figure S1-4 and Supplementary Table S1-3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec01efb0045b9433381683e911db0e2
https://doi.org/10.1158/0008-5472.22432629.v1

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Meta-analysis of human cancer single cell RNA-seq datasets using the IMMUcan database

Autor: Jordi Camps, Floriane Noël, Robin Liechti, Lucile Massenet-Regad, Sidwell Rigade, Lou Götz, Caroline Hoffmann, Elise Amblard, Melissa Saichi, Mahmoud M. Ibrahim, Jack Pollard, Jasna Medvedovic, Helge G. Roider, Vassili Soumelis

Publikováno v: Cancer research.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d09ce056f4c53ecab3034107a57a653
https://pubmed.ncbi.nlm.nih.gov/36459564

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