Výsledky vyhledávání - "G. Roger Askew"

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity

Autor: Stephen B. Spurgin, Kai Sun, William L. Holland, Judith Simcox, Cai Li, Ying Lin, Christine M. Kusminski, G Roger Askew, Jiyoung Park, Philipp E. Scherer, Donald A. McClain

Publikováno v: Nature Medicine. 18:1539-1549

Over the past decade, efforts have focused on the connection between mitochondrial dysfunction and the etiology of obesity, insulin resistance and the progression of type 2 diabetes mellitus (T2DM)1,2. Numerous studies indicate that metabolic disorde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462fdde579ef5dff2d67fa627ff4a9b4
https://doi.org/10.1038/nm.2899

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Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality

Autor: G. Roger Askew, Tianhui Zhou, Victoria Roberts, Katherine A. Fitzgerald, Lih-Ling Lin, Suzana Marusic, Vincent Ling, J. Perry Hall, Nancy L. Stedman, Zhaozhao Jiang, Paresh Thakker, Mark Ryan, Erica Marchlik, Wen Kuang, Richard Pfeifer, Stephen C. Benoit, Nadege Goutagny, Thaddeus Carlson

Publikováno v: Journal of Leukocyte Biology. 88:1171-1180

Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues, altered circulating immune cell compartments, and increased susceptibility to LPS-induced lethality. TBK1 is critical for immunity against microbial pathogens that activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2beab5dc81f0829fdc1fe59e4ebc328c
https://doi.org/10.1189/jlb.0210071

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Estrogen-Binding Sites and Their Functional Capacity in Estrogen Receptor Double Knockout Mouse Brain

Autor: G. Roger Askew, Tammy L. Dellovade, Paul J. Shughrue, Istvan Merchenthaler

Publikováno v: Endocrinology. 143:1643-1650

Early studies found estrogen-binding sites in the ER knockout (ERalphaKO) mouse brain, suggesting a splice variant of ERalpha or another ER. The discovery of ERbeta suggested that binding was due to ERbeta, although questions about an ERgamma remaine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faaec7a7d30ecaecc3a113433a722329
https://doi.org/10.1210/endo.143.5.8772

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Identification of a Specific Role for the Na,K-ATPase α2 Isoform as a Regulator of Calcium in the Heart

Autor: G. Roger Askew, Alison L. Woo, Ingrid L. Grupp, Jerry B. Lingrel, Richard A. Walsh, Gunter Grupp, Paul F. James, Michelle L. Croyle

Publikováno v: Molecular Cell. 3:555-563

It is well accepted that inhibition of the Na,K-ATPase in the heart, through effects on the Na/Ca exchanger, raises the intracellular Ca2+ concentration and strengthens cardiac contraction. However, the contribution that individual isoforms make to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407d2f50deb7c5ea7c2c39235fc46c23
https://doi.org/10.1016/s1097-2765(00)80349-4

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Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood

Autor: Neal Green, Lih-Ling Lin, J. Perry Hall, G. Roger Askew, Katherine J. Seidl, Tam Steve Yik-Kai, James D. Clark, Yonghan Hu, Jean-Baptiste Telliez, John W. Cuozzo, Sang Hsu, Aaron Winkler, Yahya Kurdi, Julie Liu

Publikováno v: The Journal of biological chemistry. 282(46)

Tumor necrosis factor alpha (TNFalpha) is a pro-inflammatory cytokine that controls the initiation and progression of inflammatory diseases such as rheumatoid arthritis. Tpl2 is a MAPKKK in the MAPK (i.e. ERK) pathway, and the Tpl2-MEK-ERK signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5eadac314a1eb8f1e36a24b92d3647c
https://pubmed.ncbi.nlm.nih.gov/17848581

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PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis

Autor: Deborah Luxenberg, Brenda A. Carito, Beatriz M. Carreno, G. Roger Askew, Tom Brown, Mihai L. Azoitei, Steve Benoit, Michael W. Leach, Christopher Groves, Laura L. Carter, Kim L. Milarski, Jeffrey W. Pelker, Junqing Cui, Mary Collins, Suzana Marusic, Jason Jussif, Gretchen Ireland, Karen Percival

Publikováno v: Journal of neuroimmunology. 182(1-2)

Interactions between PD-1 and its two differentially expressed ligands, PD-L1 and PD-L2, attenuate T cell activation and effector function. To determine the role of these molecules in autoimmune disease of the CNS, PD-1-/-, PD-L1-/- and PD-L2-/- mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2fa608723b65159db30929bd58e9174
https://pubmed.ncbi.nlm.nih.gov/17182110

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Na,K-ATPase: Cardiac Glycoside Binding and Functional Importance of Negatively Charged Amino Acids of Transmembrane Regions

Autor: Patrick J. Schultheis, G. Roger Askew, Elizabeth A. Jewell-Motz, Earl T. Wallick, Jerry B. Lingrel, James W. Van Huysse, William J. O'Brien

Publikováno v: The Sodium Pump ISBN: 9783642725135

Na+/K+-ATPase is the receptor for cardiac glycosides, a class of drugs used to treat congestive heart failure and arrhythymias. Binding of these compounds to the enzyme is antagonized by K+ ions suggesting that the binding sites for these ligands may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfd2253f98f87e1c053e7a31a2c2d415
https://doi.org/10.1007/978-3-642-72511-1_48

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