Zobrazeno 1 - 10
of 56
pro vyhledávání: '"G. Renuka Kumar"'
Autor:
Nathan L. Meyers, Tal Ashuach, Danielle E. Lyons, Mir M. Khalid, Camille R. Simoneau, Ann L. Erickson, Mehdi Bouhaddou, Thong T. Nguyen, G. Renuka Kumar, Taha Y. Taha, Vaishaali Natarajan, Jody L. Baron, Norma Neff, Fabio Zanini, Tokameh Mahmoudi, Stephen R. Quake, Nevan J. Krogan, Stewart Cooper, Todd C. McDevitt, Nir Yosef, Melanie Ott
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTHepatitis C virus (HCV) is the leading cause of death from liver disease. How HCV infection causes lasting liver damage and increases cancer risk remains unclear. Here, we identify bipotent liver stem cells as novel targets for HCV infection,
Externí odkaz:
https://doaj.org/article/f695e534948b44848663e858cae4c61b
Autor:
Rahul K. Suryawanshi, Taha Y. Taha, Maria McCavitt-Malvido, Ines Silva, Mir M. Khalid, Abdullah M. Syed, Irene P. Chen, Prachi Saldhi, Bharath Sreekumar, Mauricio Montano, Kafaya Foresythe, Takako Tabata, G. Renuka Kumar, Alicia Sotomayor-Gonzalez, Venice Servellita, Amelia Gliwa, Jenny Nguyen, Noah Kojima, Teresa Arellanor, Aallyah Bussanich, Victoria Hess, Maria Shacreaw, Lauren Lopez, Matthew Brobeck, Fred Turner, Yuzhu Wang, Sydney Ghazarian, Gregg Davis, Diviana Rodriguez, Jennifer Doudna, Lee Spraggon, Charles Y. Chiu, Melanie Ott
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
The emergence of SARS-CoV-2 recombinants is of particular concern as they can result in a sudden increase in immune evasion due to antigenic shift. Recent recombinants XBB and XBB.1.5 have higher transmissibility than previous recombinants such as
Externí odkaz:
https://doaj.org/article/312588b304fb40aebfd425ebdbee0658
Autor:
Taha Y. Taha, Irene P. Chen, Jennifer M. Hayashi, Takako Tabata, Keith Walcott, Gabriella R. Kimmerly, Abdullah M. Syed, Alison Ciling, Rahul K. Suryawanshi, Hannah S. Martin, Bryan H. Bach, Chia-Lin Tsou, Mauricio Montano, Mir M. Khalid, Bharath K. Sreekumar, G. Renuka Kumar, Stacia Wyman, Jennifer A. Doudna, Melanie Ott
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Although the SARS-CoV-2 Omicron variant (BA.1) spread rapidly across the world and effectively evaded immune responses, its viral fitness in cell and animal models was reduced. The precise nature of this attenuation remains unknown as genera
Externí odkaz:
https://doaj.org/article/49493a60ddbb416184e22cc9169a5aac
Autor:
Brian L. Le, Gaia Andreoletti, Tomiko Oskotsky, Albert Vallejo-Gracia, Romel Rosales, Katharine Yu, Idit Kosti, Kristoffer E. Leon, Daniel G. Bunis, Christine Li, G. Renuka Kumar, Kris M. White, Adolfo García-Sastre, Melanie Ott, Marina Sirota
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The novel SARS-CoV-2 virus emerged in December 2019 and has few effective treatments. We applied a computational drug repositioning pipeline to SARS-CoV-2 differential gene expression signatures derived from publicly available data. We utili
Externí odkaz:
https://doaj.org/article/4c2062c1199f494bb0611974876e19c4
Autor:
Yusuke Matsui, Lin Li, Mary Prahl, Arianna G. Cassidy, Nida Ozarslan, Yarden Golan, Veronica J. Gonzalez, Christine Y. Lin, Unurzul Jigmeddagva, Megan A. Chidboy, Mauricio Montano, Taha Y. Taha, Mir M. Khalid, Bharath Sreekumar, Jennifer M. Hayashi, Pei-Yi Chen, G. Renuka Kumar, Lakshmi Warrier, Alan H.B. Wu, Dongli Song, Priya Jegatheesan, Daljeet S. Rai, Balaji Govindaswami, Jordan Needens, Monica Rincon, Leslie Myatt, Ifeyinwa V. Asiodu, Valerie J. Flaherman, Yalda Afshar, Vanessa L. Jacoby, Amy P. Murtha, Joshua F. Robinson, Melanie Ott, Warner C. Greene, Stephanie L. Gaw
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
Pregnancy confers unique immune responses to infection and vaccination across gestation. To date, there are limited data comparing vaccine- and infection-induced neutralizing Abs (nAbs) against COVID-19 variants in mothers during pregnancy. We analyz
Externí odkaz:
https://doaj.org/article/e263e98537e14ce58365d0a07e07c9dc
Autor:
Eran Mick, Jack Kamm, Angela Oliveira Pisco, Kalani Ratnasiri, Jennifer M. Babik, Gloria Castañeda, Joseph L. DeRisi, Angela M. Detweiler, Samantha L. Hao, Kirsten N. Kangelaris, G. Renuka Kumar, Lucy M. Li, Sabrina A. Mann, Norma Neff, Priya A. Prasad, Paula Hayakawa Serpa, Sachin J. Shah, Natasha Spottiswoode, Michelle Tan, Carolyn S. Calfee, Stephanie A. Christenson, Amy Kistler, Charles Langelier
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Here, the authors provide upper airway gene expression data from patients with COVID-19 and other viral and non-viral acute respiratory illnesses. They find attenuated activation of innate immune and pro-inflammatory pathways in COVID-19 as compared
Externí odkaz:
https://doaj.org/article/408b6cd697fa4ad18907bc9b834782d0
Autor:
Sachin J. Shah, Peter N. Barish, Priya A. Prasad, Amy Kistler, Norma Neff, Jack Kamm, Lucy M. Li, Charles Y. Chiu, Jennifer M. Babik, Margaret C. Fang, Yumiko Abe-Jones, Narges Alipanah, Francisco N. Alvarez, Olga Borisovna Botvinnik, Gloria Castaneda, Rand M. Dadasovich, Jennifer Davis, Xianding Deng, Joseph L. DeRisi, Angela M. Detweiler, Scot Federman, John Haliburton, Samantha Hao, Andrew D. Kerkhoff, G. Renuka Kumar, Katherine B. Malcolm, Sabrina A. Mann, Sandra Martinez, Rupa K. Mary, Eran Mick, Lusajo Mwakibete, Nader Najafi, Michael J. Peluso, Maira Phelps, Angela Oliveira Pisco, Kalani Ratnasiri, Luis A. Rubio, Anna Sellas, Kyla D. Sherwood, Jonathan Sheu, Natasha Spottiswoode, Michelle Tan, Guixia Yu, Kirsten Neudoerffer Kangelaris, Charles Langelier
Publikováno v:
EClinicalMedicine, Vol 27, Iss , Pp 100518- (2020)
Background: Most data on the clinical presentation, diagnostics, and outcomes of patients with COVID-19 have been presented as case series without comparison to patients with other acute respiratory illnesses. Methods: We examined emergency departmen
Externí odkaz:
https://doaj.org/article/2d343b2b38d34defb7023809f69ef7d7
Autor:
Hesong Han, Albert Vallejo Gracia, Joachim J. Røise, Lydia Boike, Kristoffer Leon, Ursula Schulze-Gahmen, Michael R. Stentzel, Teena Bajaj, Dake Chen, I.-Che Li, Maomao He, Kamyar Behrouzi, Zahra Khodabakhshi, Daniel K. Nomura, Mohammad R. K. Mofrad, G. Renuka Kumar, Melanie Ott, Niren Murthy
Publikováno v:
RSC advances, vol 13, iss 16
Covalent inhibitors of the papain-like protease (PLpro) from SARS-CoV-2 have great potential as antivirals, but their non-specific reactivity with thiols has limited their development. In this report, we performed an 8000 molecule electrophile screen
Autor:
Rahul K. Suryawanshi, Irene P. Chen, Tongcui Ma, Abdullah M. Syed, Noah Brazer, Prachi Saldhi, Camille R. Simoneau, Alison Ciling, Mir M. Khalid, Bharath Sreekumar, Pei-Yi Chen, G. Renuka Kumar, Mauricio Montano, Ronne Gascon, Chia-Lin Tsou, Miguel A. Garcia-Knight, Alicia Sotomayor-Gonzalez, Venice Servellita, Amelia Gliwa, Jenny Nguyen, Ines Silva, Bilal Milbes, Noah Kojima, Victoria Hess, Maria Shacreaw, Lauren Lopez, Matthew Brobeck, Fred Turner, Frank W. Soveg, Ashley F. George, Xiaohui Fang, Mazharul Maishan, Michael Matthay, Mary Kate Morris, Debra Wadford, Carl Hanson, Warner C. Greene, Raul Andino, Lee Spraggon, Nadia R. Roan, Charles Y. Chiu, Jennifer A. Doudna, Melanie Ott
Publikováno v:
Nature, vol 607, iss 7918
SARS-CoV-2 Delta and Omicron are globally relevant variants of concern. Although individuals infected with Delta are at risk of developing severe lung disease, infection with Omicron often causes milder symptoms, especially in vaccinated individuals1
Autor:
Vaibhav Upadhyay, Rahul Suryawanshi, Preston Tasoff, Maria McCavitt-Malvido, G. Renuka Kumar, Victoria Wong Murray, Cecilia Noecker, Jordan E. Bisanz, Yulin Hswen, Connie Ha, Bharat Sreekumar, Irene P. Chen, Susan V Lynch, Melanie Ott, Sulggi Lee, Peter J. Turnbaugh
Publikováno v:
bioRxiv
Viruses targeting mammalian cells can indirectly alter the gut microbiota, potentially compounding their phenotypic effects. Multiple studies have observed a disrupted gut microbiota in severe cases of SARS-CoV-2 infection that require hospitalizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238c469306fed048d9dc89107c880a2e
https://doi.org/10.1101/2022.12.07.519508
https://doi.org/10.1101/2022.12.07.519508