Zobrazeno 1 - 10
of 366
pro vyhledávání: '"G. Radu"'
Autor:
Shen Li, Tomohiro Yokota, Ping Wang, Johanna ten Hoeve, Feiyang Ma, Thuc M. Le, Evan R. Abt, Yonggang Zhou, Rimao Wu, Maxine Nanthavongdouangsy, Abraham Rodriguez, Yijie Wang, Yen-Ju Lin, Hayato Muranaka, Mark Sharpley, Demetrios T. Braddock, Vicky E. MacRae, Utpal Banerjee, Pei-Yu Chiou, Marcus Seldin, Dian Huang, Michael Teitell, Ilya Gertsman, Michael Jung, Steven J. Bensinger, Robert Damoiseaux, Kym Faull, Matteo Pellegrini, Aldons J. Lusis, Thomas G. Graeber, Caius G. Radu, Arjun Deb
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)
Various populations of cells are recruited to the heart after cardiac injury, but little is known about whether cardiomyocytes directly regulate heart repair. Using a murine model of ischemic cardiac injury, we demonstrate that cardiomyocytes play a
Externí odkaz:
https://doaj.org/article/4f249dd668874f6a904b120bd8b43144
Publikováno v:
Annals of the Oradea University: Fascicle Management and Technological Engineering, Vol Volume XXX (XX), 2021/2, Iss 2 (2021)
Externí odkaz:
https://doaj.org/article/43a54ad2c2564fe7a633588d1b946a50
Autor:
Samantha B. Kemp, Noah Cheng, Nune Markosyan, Rina Sor, Il-Kyu Kim, Jill Hallin, Jason Shoush, Liz Quinones, Natalie V. Brown, Jared B. Bassett, Nikhil Joshi, Salina Yuan, Molly Smith, William P. Vostrejs, Kia Z. Perez-Vale, Benjamin Kahn, Feiyan Mo, Timothy R. Donahue, Caius G. Radu, Cynthia Clendenin, James G. Christensen, Robert H. Vonderheide, Ben Z. Stanger
Publikováno v:
Cancer Discovery. 13:298-311
Mutations in the KRAS oncogene are found in more than 90% of patients with pancreatic ductal adenocarcinoma (PDAC), with Gly-to-Asp mutations (KRASG12D) being the most common. Here, we tested the efficacy of a small-molecule KRASG12D inhibitor, MRTX1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5cc5c7c1f2d77d756131b0f1d60ef39
https://doi.org/10.1158/2159-8290.cd-22-1066
https://doi.org/10.1158/2159-8290.cd-22-1066
Autor:
Katharina Lückerath, Liu Wei, Wolfgang P. Fendler, Susan Evans-Axelsson, Andreea D. Stuparu, Roger Slavik, Christine E. Mona, Jeremie Calais, Matthew Rettig, Robert E. Reiter, Ken Herrmann, Caius G. Radu, Johannes Czernin, Matthias Eiber
Publikováno v:
EJNMMI Research, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract Background Prostate-specific membrane antigen (PSMA)-directed radioligand therapy (RLT) is a promising yet not curative approach in castration-resistant (CR) prostate cancer (PC). Rational combination therapies may improve treatment efficacy
Externí odkaz:
https://doaj.org/article/ee03584d5b0e4659899e23720969876c
Autor:
Matthew Garrett, Jantzen Sperry, Daniel Braas, Weihong Yan, Thuc M. Le, Jack Mottahedeh, Kirsten Ludwig, Ascia Eskin, Yue Qin, Rachelle Levy, Joshua J. Breunig, Frank Pajonk, Thomas G. Graeber, Caius G. Radu, Heather Christofk, Robert M. Prins, Albert Lai, Linda M. Liau, Giovanni Coppola, Harley I. Kornblum
Publikováno v:
Cancer & Metabolism, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract Background There is considerable interest in defining the metabolic abnormalities of IDH mutant tumors to exploit for therapy. While most studies have attempted to discern function by using cell lines transduced with exogenous IDH mutant enz
Externí odkaz:
https://doaj.org/article/642fab9d621f45ce80bff09ea33cbe6b
Autor:
Bao Ying Chen, Jessica R. Salas, Alyssa O. Trias, Arely Perez Rodriguez, Jonathan E. Tsang, Miriam Guemes, Thuc M. Le, Zoran Galic, H. Michael Shepard, Lawrence Steinman, David A. Nathanson, Johannes Czernin, Owen N. Witte, Caius G. Radu, Kenneth A. Schultz, Peter M. Clark
Publikováno v:
Immunology. 168:152-169
Multiple sclerosis (MS) is an autoimmune disease driven by lymphocyte activation against myelin autoantigens in the central nervous system leading to demyelination and neurodegeneration. The deoxyribonucleoside salvage pathway with the rate-limiting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc2389100509e821a331ad70ab321fa
https://doi.org/10.1111/imm.13569
https://doi.org/10.1111/imm.13569
Autor:
Adriana Cecilia Csakvari, Cristian Moisa, Dana G. Radu, Leonard M. Olariu, Andreea I. Lupitu, Anca Ofelia Panda, Georgeta Pop, Dorina Chambre, Vlad Socoliuc, Lucian Copolovici, Dana Maria Copolovici
Publikováno v:
Molecules, Vol 26, Iss 13, p 4041 (2021)
Cannabis sativa L. (hemp) is a plant used in the textile industry and green building material industry, as well as for the phytoremediation of soil, medical treatments, and supplementary food products. The synergistic effect of terpenes, flavonoids,
Externí odkaz:
https://doaj.org/article/06f664885bb341dc80900773748b052e
Autor:
Thuc M. Le, Soumya Poddar, Joseph R. Capri, Evan R. Abt, Woosuk Kim, Liu Wei, Nhu T. Uong, Chloe M. Cheng, Daniel Braas, Mina Nikanjam, Peter Rix, Daria Merkurjev, Jesse Zaretsky, Harley I. Kornblum, Antoni Ribas, Harvey R. Herschman, Julian Whitelegge, Kym F. Faull, Timothy R. Donahue, Johannes Czernin, Caius G. Radu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Leukemic cells depend on the nucleotide synthesis pathway to proliferate. Here the authors use metabolomics and proteomics to show that inhibition of ATR reduced the activity of these pathways thus providing a valuable therapeutic target in leukemia.
Externí odkaz:
https://doaj.org/article/ea735642f5484b8db7d0f34fe2f452fc
Autor:
Razmik Ghukasyan, Keke Liang, Kevin Chau, Luyi Li, Charlotte Chan, Evan R. Abt, Thuc Le, Joon Y. Park, Nanping Wu, Alykhan Premji, Robert Damoiseaux, Tony Luu, Amanda Labora, Khalid Rashid, Jason M. Link, Caius G. Radu, Timothy R. Donahue
Publikováno v:
Clinical Cancer Research.
Purpose: STING (Stimulator of Interferon Genes) agonists are currently in development for treatment of solid tumors, including pancreatic ductal adenocarcinoma (PDAC). Response rates to STING agonists alone have been promising yet modest and combinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adb2fc8f672f9fc3e778d9ebd8c1a176
https://doi.org/10.1158/1078-0432.ccr-22-3322
https://doi.org/10.1158/1078-0432.ccr-22-3322
Autor:
Ben Z. Stanger, Robert H. Vonderheide, James G. Christensen, Cynthia Clendenin, Caius G. Radu, Timothy R. Donahue, Feiyan Mo, Benjamin Kahn, Kia Z. Perez-Vale, William P. Vostrejs, Molly Smith, Salina Yuan, Nikhil Joshi, Jared B. Bassett, Natalie V. Brown, Liz Quinones, Jason Shoush, Jill Hallin, Il-Kyu Kim, Rina Sor, Nune Markosyan, Noah Cheng, Samantha B. Kemp
KRASG12D inhibition alters the tumor immune microenvironment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a7afbfb1eadc3d2b6d4bd86368d034
https://doi.org/10.1158/2159-8290.22541970.v1
https://doi.org/10.1158/2159-8290.22541970.v1
