Zobrazeno 1 - 10
of 39
pro vyhledávání: '"G. R. Uhl"'
Autor:
D. E. Dar, G. R. Uhl, Frank I. Carroll, B. S. Slusher, M. Thiruvazhi, Theresa A. Kopajtic, A. Gamliel, Shigeo Kitayama, Philip Abraham
Publikováno v:
European Journal of Medicinal Chemistry. 40:1013-1021
A series of trihexyphenidyl (THP) analogs were used to search for a derivative that could serve as a cocaine inhibitor. A compound that blocks binding of the cocaine analog carboxyfluorotropane (CFT), allows dopamine uptake and exhibits low side effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d9d2572ae3b5c0f28daea715f3563f
https://doi.org/10.1016/j.ejmech.2005.04.016
https://doi.org/10.1016/j.ejmech.2005.04.016
Autor:
Martin J. Corbett, Cecil Mark Eppler, J Linden, J.D. Hulmes, D R Luthin, B Johnson, J B Wang, G R Uhl
Publikováno v:
Journal of Biological Chemistry. 268:26447-26451
A rat brain opioid receptor protein was isolated by binding [epsilon-biotinyl-Lys32] beta-endorphin to membranes, solubilizing the receptor-ligand (R.L) complex with deoxycholate-lysophosphatidylcholine and purifying on immobilized streptavidin and w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8785420e32e5bc7b88582a015694cb47
https://doi.org/10.1016/s0021-9258(19)74335-x
https://doi.org/10.1016/s0021-9258(19)74335-x
Autor:
F. I. Carroll, B. S. Slusher, G. R. Uhl, D. E. Dar, Philip Abraham, Shigeo Kitayama, Theresa Kopajtic, M. Thiruvazhi, A. Gamliel
Publikováno v:
ChemInform. 37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd15a38447c9e39f34c9615695f4ad0f
https://doi.org/10.1002/chin.200608220
https://doi.org/10.1002/chin.200608220
Autor:
D L, Murphy, G R, Uhl, A, Holmes, R, Ren-Patterson, F S, Hall, I, Sora, S, Detera-Wadleigh, K P, Lesch
Publikováno v:
Genes, brain, and behavior. 2(6)
Current evidence indicates that virtually all neuropsychiatric disorders, like many other common medical disorders, are genetically complex, with combined influences from multiple interacting genes, as well as from the environment. However, additive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d734ce3141a921f34af05a2fb042b403
https://pubmed.ncbi.nlm.nih.gov/14653307
https://pubmed.ncbi.nlm.nih.gov/14653307
Publikováno v:
Genes, brain, and behavior. 2(2)
Homozygous mu-opioid receptor (MOR) knockout (KO) mice developed on a chimeric C57B6/129SV background lack morphine-induced antinociception, locomotion and reward. Therefore it appears that MOR largely mediates these morphine actions. However, one fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a0e98c3e11d964877622a6e80d20d261
https://pubmed.ncbi.nlm.nih.gov/12884968
https://pubmed.ncbi.nlm.nih.gov/12884968
Publikováno v:
DNA sequence : the journal of DNA sequencing and mapping. 12(5-6)
The functional significance of heterotrimeric guanine nucleotide binding protein (G protein) for the many physiological processes including the molecular mechanisms of drug addiction have been described. In investigating the changes of mRNA expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9ffa8d55c7cacf389f593146155fbf3f
https://pubmed.ncbi.nlm.nih.gov/11913780
https://pubmed.ncbi.nlm.nih.gov/11913780
Autor:
D J, Vandenbergh, L A, Rodriguez, E, Hivert, J H, Schiller, G, Villareal, E W, Pugh, H, Lachman, G R, Uhl
Publikováno v:
American journal of medical genetics. 96(5)
Substance abuse is a complex behavior that is caused by both environmental and genetic factors. Work to understand the genetic factors has focused on genes related to dopamine activity because of its critical role in rewarding and reinforcing behavio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5373f96b9c0f24542f138f94ec7f2ec6
https://pubmed.ncbi.nlm.nih.gov/11054777
https://pubmed.ncbi.nlm.nih.gov/11054777
Publikováno v:
Molecular pharmacology. 57(6)
Polar residues in dopamine transporter (DAT) transmembrane domains (TMs) are likely to act individually and even interactively in recognizing cocaine and dopamine. We initially evaluated the effects of alanine substitution mutants that remove the pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b262c35f9b7aae988301b8fd2c81ad96
https://pubmed.ncbi.nlm.nih.gov/10825379
https://pubmed.ncbi.nlm.nih.gov/10825379
Publikováno v:
The Journal of comparative neurology. 410(2)
Cholinergic activation of dopaminergic neurons in the ventral tegmental area (VTA) is thought to play a major role in cognitive functions and reward. These dopaminergic neurons differentially project to cortical and limbic forebrain regions, where th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6db6f09628501166ae67042bf1ef196f
https://pubmed.ncbi.nlm.nih.gov/10414527
https://pubmed.ncbi.nlm.nih.gov/10414527
Autor:
R B, Rothman, M L, Silverthorn, J R, Glowa, D, Matecka, K C, Rice, F I, Carroll, J S, Partilla, G R, Uhl, D J, Vandenbergh, C M, Dersch
Publikováno v:
Synapse (New York, N.Y.). 28(4)
[125I]RTI-55 is a cocaine analog with high affinity for dopamine (DA) and serotonin (5-HT) transporters. Quantitative ligand binding studies revealed a novel high affinity [125I]RTI-55 binding site assayed under 5-HT transporter (SERT) conditions whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::08fbe4f1e08f5093e6f1fe68a94edc63
https://pubmed.ncbi.nlm.nih.gov/9517841
https://pubmed.ncbi.nlm.nih.gov/9517841