Zobrazeno 1 - 9
of 9
pro vyhledávání: '"G. R. Sunagatullina"'
Publikováno v:
Russian Journal of Organic Chemistry. 58:724-726
Publikováno v:
Russian Journal of Organic Chemistry. 57:889-904
A new chiral 10,11-didehydro analog of epothilone D with isosteric substitution in the C15–C3 fragment of natural epothilones has been synthesized.
Publikováno v:
Russian Journal of Organic Chemistry. 56:1140-1145
Yamaguchi esterification of (2Z,5S,6E)-5-(hydroxymethyl)-2,6-dimethyl-7-(2-methyl-1,3-thiazol-4-yl)hepta-2,6-dienal with (2R,5R,6S,7S)-2-(methoxymethoxy)-3,3,5,7-tetramethyl-4-oxo-9-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl-6-[(triethylsilyl)oxy]nonanoic
Publikováno v:
Russian Journal of Organic Chemistry. 55:1370-1373
A synthetic approach is described for the transformation of R-(-)-carvone to methyl (2Z,5S,6E)-5-[(tert-butoxycarbonyl)amino]-2,6-dimethyl-7-(2-methyl-1,3-thiazol-4-yl)hepta-2,6-dienoate, the key building block for the convergent synthesis of the kno
Publikováno v:
Mendeleev Communications. 31:696-697
R-Carvone on heating with Pb(OAc)4 in benzene gives (2RS)-2-hydroxy-2-[(1S)-4-methyl-5-oxocyclohex-3-en-1-yl)]-prop-1-yl bis(acetoxy)acetate. Alkaline hydrolysis of this compound affords the corresponding diol which under acidic catalysis is transfor
Publikováno v:
Russian Journal of Organic Chemistry. 54:1548-1552
The synthesis of acyclic precursors to epothilone D analogs has been explored. Optimal conditions have been found for enolization of (1R)-1-(1,3-dithiolan-2-yl)-1-(methoxymethoxy)-2,2-dimethylpentan-3-one and its aldol condensation with C6‒C21 and
Publikováno v:
Russian Journal of Organic Chemistry. 55:1439-1441
Coupling of previously synthesized chiral building blocks via Yamaguchi esterification has been studied with the goal of obtaining epothilone D isosteres. Some peculiar features of the Yamaguchi esterification stage have been revealed, which are rela
Publikováno v:
Russian Journal of Organic Chemistry. 53:1687-1690
Synthesis was developed of a new chiral block for epothilone analogs from R-(‒)-pantolactone.
Publikováno v:
Mendeleev Communications. 28:587-588
Condensation of separately obtained C1–C9 and C10–C21 chiral blocks under Yamaguchi conditions affords the corresponding ester, an acyclic precursor of an epothilone D analogue. The reaction is accompanied by the formation of a side product of ac