Zobrazeno 1 - 10
of 17
pro vyhledávání: '"G. R. Hudes"'
Publikováno v:
British Journal of Cancer
Increases of individual beta tubulin isotypes in antimicrotubule drug resistant cell lines have been reported by several laboratories. We have previously described elevations in beta(III)and beta(IVa)isotypes in estramustine and paclitaxel resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8fc52a8282dc5ac23707db3498d2187
https://doi.org/10.1054/bjoc.2001.1956
https://doi.org/10.1054/bjoc.2001.1956
Autor:
G R, Hudes, C E, Szarka, A, Adams, S, Ranganathan, R A, McCauley, L M, Weiner, C J, Langer, S, Litwin, G, Yeslow, T, Halberr, M, Qian, J M, Gallo
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(8)
Perillyl alcohol (POH) is a monoterpene with anticarcinogenic and antitumor activity in murine tumor models. Putative mechanisms of action include activation of the transforming growth factor beta pathway and/or inhibition of p21ras signaling, leadin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::958794677c4b1b12f161a06a286b6e07
https://pubmed.ncbi.nlm.nih.gov/10955786
https://pubmed.ncbi.nlm.nih.gov/10955786
Publikováno v:
Cancer. 85(2)
Chemotherapy has a limited impact on adenocarcinoma of the stomach. Although biochemical modulation of 5-fluorouracil (5-FU) by leucovorin (LV) and interferon-alpha (IFN-alpha) has improved the outcomes of patients with metastatic colorectal carcinom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::593f6e2a03186441ba8e8b7651d27ca6
https://pubmed.ncbi.nlm.nih.gov/10023694
https://pubmed.ncbi.nlm.nih.gov/10023694
Publikováno v:
The Prostate. 30(4)
beta-tubulin, the intracellular target of several antimicrotubule agents, is encoded by at least six genes and exists as multiple isotypes with tissue-specific expression. Previous in vitro studies indicated that tubulin isotype composition may affec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::04de860ba98d22a4a71c2838025929d6
https://pubmed.ncbi.nlm.nih.gov/9111604
https://pubmed.ncbi.nlm.nih.gov/9111604
Autor:
N, Haas, G R, Hudes
Publikováno v:
Cancer chemotherapy and biological response modifiers. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a9c9ee8200cb08932384711b897c332b
https://pubmed.ncbi.nlm.nih.gov/9551229
https://pubmed.ncbi.nlm.nih.gov/9551229
Publikováno v:
Cancer research. 56(11)
Estramustine (EM), an antimicrotubule agent, is effective against hormone-refractory prostate cancer when used in combination with vinblastine or paclitaxel. To understand the effect of EM on beta-tubulin, a cellular target for this class of drugs, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fed776f824cc6414e95d56edeb8506e
https://pubmed.ncbi.nlm.nih.gov/8653701
https://pubmed.ncbi.nlm.nih.gov/8653701
Publikováno v:
Seminars in oncology. 22(5 Suppl 12)
Combination antimicrotubule therapy with estramustine phosphate (EMP) and vinblastine has reproducible activity in metastatic hormone-refractory prostate cancer (HRPC) with an objective response rate of 31%. Although paclitaxel (Taxol; Bristol-Myers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e848cac0daf07c886c0c1dd46840c487
https://pubmed.ncbi.nlm.nih.gov/7481860
https://pubmed.ncbi.nlm.nih.gov/7481860
Publikováno v:
Seminars in oncology. 22(3 Suppl 6)
Estramustine phosphate is a unique antimitotic agent that binds to tubulin and microtubule-associated proteins. Preclinically, estramustine combined with other microtubule inhibitors, like vinblastine or paclitaxel (Taxol; Bristol-Myers Squibb Compan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3fef0f7792dcffaaf3a68faa3c0ebd50
https://pubmed.ncbi.nlm.nih.gov/7597435
https://pubmed.ncbi.nlm.nih.gov/7597435
Publikováno v:
Cancer. 75(10)
Estramustine previously has been shown to interact with P-glycoprotein and to restore intracellular accumulation of vinblastine and paclitaxel in cells overexpressing this drug transporter. However, the ability of estramustine to potentiate the cytot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::26b042ec2932289cb4ec0bd1caf3ae49
https://pubmed.ncbi.nlm.nih.gov/7736407
https://pubmed.ncbi.nlm.nih.gov/7736407
Publikováno v:
Cancer research. 54(5)
Topotecan (SKF 104864, hycamptamine, NSC 609699) is believed to exert its cytotoxic effects through inhibition of topoisomerase I, the activity of which recovers rapidly on removal of the drug in vitro. In vivo studies show that the activity of topot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ab036483a5649a1ff083746654dd0fe
https://pubmed.ncbi.nlm.nih.gov/8118810
https://pubmed.ncbi.nlm.nih.gov/8118810