Výsledky vyhledávání - "G. R. Douglas"

In vivo transgenic mutation assays

Autor: J A, Heddle, S, Dean, T, Nohmi, M, Boerrigter, D, Casciano, G R, Douglas, B W, Glickman, N J, Gorelick, J C, Mirsalis, H J, Martus, T R, Skopek, V, Thybaud, K R, Tindall, N, Yajima

Publikováno v: Environmental and molecular mutagenesis. 35(3)

Transgenic rodent gene mutation models provide quick and statistically reliable assays for mutations in the DNA from any tissue. For regulatory applications, assays should be based on neutral genes, be generally available in several laboratories, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9e02719958bc93ea898d15766add41be
https://pubmed.ncbi.nlm.nih.gov/10737959

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Comparative Performance of Conventional and Molecular Dosimetry Methods in Environmental Biomonitoring

Autor: Imre S. Otvos, G. van Frankenhuyzen, G. R. Douglas, Azam F. Tayabali, J. Dugal, J M Rancourt, Verner L. Seligy, A. G. Szabo, G. Rousseau

Publikováno v: Rapid Methods for Analysis of Biological Materials in the Environment ISBN: 9789048154555

Capacity building in environmental biomonitoring is a key component of sustainable development. This paper addresses this subject in relation to: practical methods for general and specific monitoring of environmental biohazards; conductance of compli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7b51e1aae5399b8cbff8618bbefa5c5
https://doi.org/10.1007/978-94-015-9534-6_22

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Evidence for the lack of base-change and small-deletion mutation induction by trichloroethylene in lacZ transgenic mice

Autor: G R, Douglas, J D, Gingerich, L M, Soper, M, Potvin, S, Bjarnason

Publikováno v: Environmental and molecular mutagenesis. 34(2-3)

Trichloroethylene (TCE) is a widely used industrial solvent employed mainly for degreasing and cold-cleaning metal parts. It is also used for dry cleaning, and in the production of a number of chemical products. It has been shown to induce liver and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::56263d22c9e12e81bc0a2697cf6999a3
https://pubmed.ncbi.nlm.nih.gov/10529743

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The ability of Medmont M600 automated perimetry to detect threats to fixation

Autor: L, Zhang, S M, Drance, G R, Douglas

Publikováno v: Journal of glaucoma. 6(4)

The authors studied the sensitivity and specificity of the Medmont M600 central 10 degrees program (Medmont PTY Ltd., Camberwell, Victoria, Australia) in identifying paracentral threats to fixation mapped on the Humphrey program 10-2 (Humphrey Inst.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0d5a1b798bead14aa5a24a6f152967ef
https://pubmed.ncbi.nlm.nih.gov/9264306

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Comparison of psychophysical and electrophysiological testing in early glaucoma

Autor: S L, Graham, S M, Drance, B C, Chauhan, N V, Swindale, P, Hnik, F S, Mikelberg, G R, Douglas

Publikováno v: Investigative ophthalmologyvisual science. 37(13)

To compare the sensitivity and specificity of a wide range of psychophysical and electrophysiological tests in the detection of early glaucomatous damage.Forty-three normals and 43 patients with early glaucoma, some still without field defects, were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cccb6bca612dcff64cef5c2b7a17dc62
https://pubmed.ncbi.nlm.nih.gov/8977479

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Database and software for the analysis of mutations at the lacZ locus in transgenic rodents

Autor: N F, Cariello, G R, Douglas

Publikováno v: Environmental and molecular mutagenesis. 28(2)

The use of transgenic rodents is becoming increasingly widespread in genetic toxicology. In an effort to centralize and standardize the information regarding mutations in rodents bearing the lacZ transgene, we have created a computerized database tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd6e19c545a2264dc64ad7b8dd7ac5d8
https://pubmed.ncbi.nlm.nih.gov/8844996

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Temporal and molecular characteristics of lacZ mutations in somatic tissues of transgenic mice

Autor: G R, Douglas, J, Jiao, J D, Gingerich, L M, Soper, J A, Gossen

Publikováno v: Environmental and molecular mutagenesis. 28(4)

In order to help establish criteria for optimizing protocols for in vivo mutation studies, lacZ transgenic mice (Muta mouse) were treated with five consecutive daily doses of ethylnitrosourea (50 mg/kg), sampled at times up to 55 days after treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3224328d9ce267236c6f65e9244f2b9a
https://pubmed.ncbi.nlm.nih.gov/8991059

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Ambulatory blood pressure monitoring in glaucoma. The nocturnal dip

Autor: S L, Graham, S M, Drance, K, Wijsman, G R, Douglas, F S, Mikelberg

Publikováno v: Ophthalmology. 102(1)

Hypoperfusion of the optic nerve head may be among the significant factors relating to glaucoma damage. The physiologic nocturnal blood pressure "dip" may be exaggerated in some patients and may compromise local vascular supply.Twenty-four-hour ambul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::20c1d79c285dddce3774a7ec5953af40
https://pubmed.ncbi.nlm.nih.gov/7831043

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