Zobrazeno 1 - 10
of 48
pro vyhledávání: '"G. R. Dawson"'
Autor:
Steven Williams, Martina T. Mitterschiffthaler, Ellen McCulloch, Robin G. Morris, Colin T. Dourish, Ellen M. Migo, Owen O'Daly, Michael D. Kopelman, Andrew Simmons, Gordon K. Wilcock, G R Dawson, Elena Antonova, Kevin J. Craig, Stephen H D Jackson
Publikováno v:
Aging, Neuropsychology, and Cognition. 23:196-217
Spatial navigation requires a well-established network of brain regions, including the hippocampus, caudate nucleus, and retrosplenial cortex. Amnestic Mild Cognitive Impairment (aMCI) is a condition with predominantly memory impairment, conferring a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cac8da8b651f4a94b627bcbb2bbe045
https://doi.org/10.1080/13825585.2015.1073218
https://doi.org/10.1080/13825585.2015.1073218
Autor:
A. Rich, Sue Wilson, Kevin J. Craig, David J. Nutt, Jayne E Bailey, G R Dawson, Colin T. Dourish, Alison Diaper
Publikováno v:
Human Psychopharmacology: Clinical and Experimental. 28:562-575
It is generally thought that venlafaxine raises blood pressure at higher doses; however, some studies have found no effect or a decrease in blood pressure. The aim of this study was to evaluate the cardiovascular (CV) effects of 3weeks of dosing with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a485390b57db498ba65751b06b54de2
https://doi.org/10.1002/hup.2346
https://doi.org/10.1002/hup.2346
The effect of a clinically effective and non-effective dose of lorazepam on 7.5% CO2-induced anxiety
Autor:
A. Papadopoulos, Colin T. Dourish, Jayne E Bailey, Alison Diaper, David J. Nutt, G R Dawson, A. Rich
Publikováno v:
Human Psychopharmacology: Clinical and Experimental. 27:540-548
Symptoms of anxiety induced by 7.5% CO₂ inhalation can be attenuated by acute administration of GABA(A) receptor anxiolytics such as lorazepam and alprazolam. This study investigated if these effects are dose-related, by comparing a 0.5 mg dose (co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::218359ea7be09933f529a68e8f2873c5
https://doi.org/10.1002/hup.2261
https://doi.org/10.1002/hup.2261
Autor:
Sandra M. Sanabria-Bohórquez, J. N. de Hoon, K. Van Laere, Richard Hargreaves, Raymond E. Gibson, Spencer J. Tye, Leslie J. Street, Ruth M. McKernan, I De Lepeleire, Robert W. Carling, Keith A. Wafford, Andrew Pike, John R. Atack, Guy Bormans, Christine Ryan, David James Hallett, HD Burns, M. G Murphy, Wai-Si Eng, A. Van Hecken, G. R. Dawson
Publikováno v:
Journal of Psychopharmacology. 25:329-344
In the accompanying paper we describe how MRK-409 unexpectedly produced sedation in man at relatively low levels of GABAA receptor occupancy (∼10%). Since it was not clear whether this sedation was mediated via the α2/α3 or α1 GABAA subtype(s),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea0a5ae22a6d2851dd26b1e9a8bbbb4
https://doi.org/10.1177/0269881109354928
https://doi.org/10.1177/0269881109354928
Autor:
J. N. de Hoon, Guy Bormans, John R. Atack, M. G Murphy, Sandra M. Sanabria-Bohórquez, I De Lepeleire, A. Van Hecken, Keith A. Wafford, G. R. Dawson, K. Van Laere, Richard Hargreaves, Leslie J. Street, Ruth M. McKernan, Spencer J. Tye, HD Burns
Publikováno v:
Journal of Psychopharmacology. 25:314-328
MRK-409 binds to α1-, α2-, α3- and α5-containing human recombinant GABAA receptors with comparable high affinity (0.21–0.40 nM). However, MRK-409 has greater agonist efficacy at the α3 compared with α1 subtypes (respective efficacies relative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e190b386986f0d8f06dedccdb3ce130
https://doi.org/10.1177/0269881109354927
https://doi.org/10.1177/0269881109354927
Autor:
M. S. B. Huda, John P.H. Wilding, Terence M. Dovey, Emma Boyland, G R Dawson, Jason C.G. Halford, Steven J. Cooper, Colin T. Dourish
Publikováno v:
Journal of Psychopharmacology. 24:99-109
Given the suggestion that many potential anti-obesity drugs may enhance within-meal satiation, few studies have directly measured the effects of any drug on the microstructure of human eating behaviour. The effects of 7 days dosing with sibutramine 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4ab5f12667a6c7181b724c80e64a29
https://doi.org/10.1177/0269881108095195
https://doi.org/10.1177/0269881108095195
Autor:
G. R. Dawson, H.V. Morris, John R. Atack, David N. Stephens, Thomas W. Rosahl, David S. Reynolds
Publikováno v:
Pharmacology Biochemistry and Behavior. 90:9-18
alpha2 subunit-containing GABA(A) receptors are involved in incentive learning associated with cocaine, and in cocaine addiction. Deletion of alpha2-containing receptors abolishes cocaine-induced behavioural sensitisation (BS), while selective activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8841a61a0a9de5f343925206cb1c004
https://doi.org/10.1016/j.pbb.2008.02.010
https://doi.org/10.1016/j.pbb.2008.02.010
Autor:
Paul J. Whiting, Frances A. Bromidge, Thomas W. Rosahl, David S. Reynolds, Robert J. Newman, John R. Atack, G. R. Dawson, Gillian F. O'Meara
Publikováno v:
Neuropharmacology. 44:190-198
The GABA(A) receptor system provides the major inhibitory control in the CNS, with the alpha 1 beta 2 gamma 2 subunit combination being the most abundant and widely distributed form of the receptor. The alpha1 subunit knock-out (alpha1 KO) mice had a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a56489c3aec247e418f4ae271fd539
https://doi.org/10.1016/s0028-3908(02)00370-2
https://doi.org/10.1016/s0028-3908(02)00370-2
Autor:
G R Dawson, Francesca Perini, John Francis William Deakin, Antony Loebel, Hiroyuki Nishikawa, K. Koblan, J. Nazimek, U. Campbell, S. Hopkins, Michael Browning
Publikováno v:
European Neuropsychopharmacology. 27:S60
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73681b26a39ec83835dae74541169b5c
https://doi.org/10.1016/s0924-977x(17)30131-1
https://doi.org/10.1016/s0924-977x(17)30131-1
Autor:
Owen O'Daly, Gordon K. Wilcock, Ellen McCulloch, Kevin J. Craig, Michael D. Kopelman, Stephen H D Jackson, Steven Williams, G R Dawson, Colin T. Dourish, Ellen M. Migo, Andrew Simmons, Martina T. Mitterschiffthaler, Robin G. Morris
Publikováno v:
Migo, E M, Mitterschiffthaler, M, O'Daly, O, Dawson, G R, Dourish, C T, Craig, K J, Simmons, A, Wilcock, G K, McCulloch, E, Jackson, S H D, Kopelman, M D, Williams, S C R & Morris, R G 2014, ' Alterations in working memory networks in amnestic mild cognitive impairment ', Aging, Neuropsychology and Cognition, vol. 22, no. 1, pp. 106-127 . https://doi.org/10.1080/13825585.2014.894958
Patients with amnestic mild cognitive impairment (aMCI) show preserved or mildly impaired working memory, despite their deficits in episodic memory. We aimed to identify performance and/or neural differences between aMCI patients and matched controls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b43e4e34a7861eabb666a48cd8d7720
https://kclpure.kcl.ac.uk/en/publications/60960e98-715a-4f00-af2e-fd989aa2acf6
https://kclpure.kcl.ac.uk/en/publications/60960e98-715a-4f00-af2e-fd989aa2acf6
