Zobrazeno 1 - 10
of 208
pro vyhledávání: '"G. Pizzorno"'
Autor:
J R Bertino, Diane E. McCloskey, B G Rowan, Cynthia A. Russell, Enrico Mini, John J. McGuire, G. Pizzorno
Publikováno v:
Journal of Biological Chemistry. 266:6181-6187
Determinants of methotrexate (MTX) resistance in cell lines resistant to short, but not continuous, MTX exposure were investigated since such lines may have relevance to clinical resistance. CCRF-CEM R30dm (R30dm), cloned from CCRF-CEM R30/6 (a MTX-r
Publikováno v:
Cancer research. 61(18)
Uridine phosphorylase (UPase) is a key enzyme in the pyrimidine salvage pathway. It reversibly catalyzes the catabolism of uridine to uracil; controls the homeostatic regulation of uridine concentration in plasma and tissues; and plays a role in the
Autor:
X Y, Peng, J H, Won, T, Rutherford, T, Fujii, D, Zelterman, G, Pizzorno, E, Sapi, J, Leavitt, B, Kacinski, R, Crystal, P, Schwartz, A, Deisseroth
Publikováno v:
Cancer research. 61(11)
A 2.4-kb truncated L-plastin promoter was inserted either 5' to the LacZ gene (Ad-Lp-LacZ) or 5' to the cytosine deaminase (CD) gene (Ad-Lp-CD) in a replication-incompetent adenoviral vector backbone. Infectivity and cytotoxicity experiments with the
Publikováno v:
The Journal of biological chemistry. 276(16)
Uridine phosphorylase (UPase), a key enzyme in the pyrimidine salvage pathway, is associated with the intermediate filament protein vimentin, in NIH 3T3 fibroblasts and colon 26 cells. Affinity chromatography was utilized to purify UPase from colon 2
Publikováno v:
European Journal of Cancer Supplements. 8:141-142
Autor:
B, Burtness, M, Belker, M, Stoltz, K M, Peccerillo, L A, Lamb, S E, Chmael, A, McKeon, M B, Clark, J, Winship, J C, Marsh, G, Pizzorno, V T, DeVita
Publikováno v:
Cancer journal (Sudbury, Mass.). 6(5)
(E)-2'-fluoromethylene-2'-deoxycytidine is a novel antimetabolite. Preclinical tests have shown antiproliferative activity in various human tumor xenograft models and have also indicated that efficacy is greatest with frequent dosing schedules. We co
Autor:
W J, Hwu, R R, Salem, J, Pollak, M, Rosenblatt, E, D'Andrea, J J, Leffert, S, Faraone, J C, Marsh, G, Pizzorno
Publikováno v:
Oncology research. 11(11-12)
A dose escalation study of hepatic arterial infusion of doxorubicin during hemodynamic isolation of the liver (the Delcath system) was conducted to: 1) study the pharmacokinetics of regional doxorubicin therapy, and 2) define therapeutic efficacy in
Publikováno v:
Cancer research. 59(19)
Uridine phosphorylase (UPase) plays an important role in the activation of 5-fluorouracil and in the regulation of tissue and plasma concentration of uridine, a potential biochemical modulator of 5-fluorouracil therapy. UPase expression is affected b
Publikováno v:
Cancer research. 59(1)
Biochemical modulation of 5-fluorouracil (5-FU) has been used over the past 20 years to improve the therapeutic efficacy of this antineoplastic agent. Recently, modulation of the catabolic pathway of this fluoropyrimidine has been the focus of extens