Numerical study of intrathecal drug delivery to a permeable spinal cord: effect of catheter position and angle

Autor: Benjamin Kehlet, Bryn A. Martin, G. Pizzichelli, Øyvind Evju, Marie E. Rognes, Edoardo Sinibaldi, Kent-Andre Mardal

Publikováno v: Computer Methods in Biomechanics and Biomedical Engineering. 20:1599-1608

Intrathecal delivery is a procedure involving the release of therapeutic agents into the cerebrospinal fluid (CSF) hrough a catheter. It holds promise for treating high-impact central nervous system pathologies, for which systemic administration rout

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628d95e7f1093a4a07ee161b9537a7ba
https://doi.org/10.1080/10255842.2017.1393805

A numerical investigation of intrathecal isobaric drug dispersion within the cervical subarachnoid space

Autor: Edoardo Sinibaldi, Kent-Andre Mardal, Mikael Mortensen, Per Thomas Haga, Bryn A. Martin, G. Pizzichelli, Miroslav Kuchta, Soroush Heidari Pahlavian

Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0173680 (2017)
PLoS ONE

Intrathecal drug and gene vector delivery is a procedure to release a solute within the cerebrospinal fluid. This procedure is currently used in clinical practice and shows promise for treatment of several central nervous system pathologies. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a9dd21c5de1fa4d336cdc78087325e
https://doaj.org/article/51ea410f33344f88ad71db479f3f5dda

Closed-loop control scheme for the Euglycemic Hyperinsulinemic Clamp: validation on virtual patients

Autor: Simona Panunzi, A. De Gaetano, Pasquale Palumbo, Pierdomenico Pepe, G. Pizzichelli

Publikováno v: Scopus-Elsevier
19th IFAC World Congress, Cape Town, South Africa, 2014
info:cnr-pdr/source/autori:P. Palumbo, G. Pizzichelli, P. Pepe, S. Panunzi, A. De Gaetano/congresso_nome:19th IFAC World Congress/congresso_luogo:Cape Town, South Africa/congresso_data:2014/anno:2014/pagina_da:/pagina_a:/intervallo_pagine

A closed-loop control scheme is here investigated, for the Euglycemic Hyperinsulinemic Clamp (EHC), the gold standard experiment to estimate the individual insulin sensitivity. During the EHC large amounts of insulin are administered intra-venously t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc299925a28dea258ed91cec6628dcc9
https://doi.org/10.3182/20140824-6-za-1003.01934

Model-based control of plasma glycemia: Tests on populations of virtual patients

Autor: G. Pizzichelli, Simona Panunzi, A. De Gaetano, Pasquale Palumbo, Pierdomenico Pepe

Publikováno v: Mathematical biosciences 257 (2014): 2–10. doi:10.1016/j.mbs.2014.09.003
info:cnr-pdr/source/autori:Palumbo, Pasquale; Pizzichelli, G.; Panunzi, Simona; Pepe, Pierdomenico; De Gaetano, Andrea M./titolo:Model-based control of plasma glycemia: Tests on populations of virtual patients/doi:10.1016%2Fj.mbs.2014.09.003/rivista:Mathematical biosciences/anno:2014/pagina_da:2/pagina_a:10/intervallo_pagine:2–10/volume:257

Closed-loop devices delivering medical treatments in an automatic fashion clearly require a thorough preliminary phase according to which the proposed control law is tested and validated as realistically as possible, before arranging in vivo experime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10d97a5c6e2ff959e37a18cb6a95aea
http://hdl.handle.net/11697/16549

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