Zobrazeno 1 - 10 of 767 pro vyhledávání: '"G. Pattenden"'
1
Akademický článek
Type II innate lymphoid cell plasticity contributes to impaired reconstitution after allogeneic hematopoietic stem cell transplantation
Autor: Sonia J. Laurie, Joseph P. Foster, Danny W. Bruce, Hemamalini Bommiasamy, Oleg V. Kolupaev, Mostafa Yazdimamaghani, Samantha G. Pattenden, Nelson J. Chao, Stefanie Sarantopoulos, Joel S. Parker, Ian J. Davis, Jonathan S. Serody
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Type II innate lymphoid cells (ILC2s) maintain homeostasis and barrier integrity in mucosal tissues. In both mice and humans, ILC2s poorly reconstitute after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Determining the mec
Externí odkaz: https://doaj.org/article/deafa590173041a485a51c32ab3e3f46
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2
Akademický článek
Nuclear actin structure regulates chromatin accessibility
Autor: Buer Sen, Zhihui Xie, Michelle D. Thomas, Samantha G. Pattenden, Sean Howard, Cody McGrath, Maya Styner, Gunes Uzer, Terrence S. Furey, Janet Rubin
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Polymerized β-actin may provide a structural basis for chromatin accessibility and actin transport into the nucleus can guide mesenchymal stem cell (MSC) differentiation. Using MSC, we show that using CK666 to inhibit Arp2/3 directed second
Externí odkaz: https://doaj.org/article/f739fc9dd5c349e3a0bd8f404b6721d5
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3
Akademický článek
Behind the screen: drug discovery using the big data of phenotypic analysis
Autor: Merrill M. Froney, Michael B. Jarstfer, Samantha G. Pattenden, Amanda C. Solem, Olubunmi O. Aina, Melissa R. Eslinger, Aeisha Thomas, Courtney M. Alexander
Publikováno v: Frontiers in Education, Vol 9 (2024)
Technological advances in drug discovery are exciting to students, but it is challenging for faculty to maintain the pace with these developments, particularly within undergraduate courses. In recent years, a High-throughput Discovery Science and Inq
Externí odkaz: https://doaj.org/article/e1f45109b2a44578b52ad0f2fcac0650
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5
Akademický článek
MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing
Autor: Tamara Vital, Aminah Wali, Kyle V. Butler, Yan Xiong, Joseph P. Foster, Shelsa S. Marcel, Andrew W. McFadden, Valerie U. Nguyen, Benton M. Bailey, Kelsey N. Lamb, Lindsey I. James, Stephen V. Frye, Amber L. Mosely, Jian Jin, Samantha G. Pattenden, Ian J. Davis
Publikováno v: Frontiers in Oncology, Vol 13 (2023)
Ewing sarcoma is a cancer of children and young adults characterized by the critical translocation-associated fusion oncoprotein EWSR1::FLI1. EWSR1::FLI1 targets characteristic genetic loci where it mediates aberrant chromatin and the establishment o
Externí odkaz: https://doaj.org/article/7ebda3c984ec4911991fbe839ad7aab9
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9
Data from Discrete Adaptive Responses to MEK Inhibitor in Subpopulations of Triple-Negative Breast Cancer
Autor: Gary L. Johnson, Ian J. Davis, Samantha G. Pattenden, Charlene Santos, Darshan Singh, Noah Sciaky, José F. Olivares-Quintero, Mélodie P. Noël, Samantha M. Bevill, Jon S. Zawistowski, Joseph P. Foster, Daniel R. Goulet
Triple-negative breast cancers contain a spectrum of epithelial and mesenchymal phenotypes. SUM-229PE cells represent a model for this heterogeneity, maintaining both epithelial and mesenchymal subpopulations that are genomically similar but distinct
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00a829429d0836350469a804f0b1f42e
https://doi.org/10.1158/1541-7786.c.6541198
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