Výsledky vyhledávání - "G. PRIMOFIORE"

Pyrido[1,2-a]pyrimidin-4-one derivatives as a novel class of selective aldose reductase inhibitors exhibiting antioxidant activity

Autor: C. LA MOTTA, S. SARTINI, L. MUGNAINI, F. SIMORINI, S. TALIANI, S. SALERNO, A. M. MARINI, G. PRIMOFIORE, F. DA SETTIMO, LAVECCHIA, ANTONIO, NOVELLINO, ETTORE, M. CANTORE, P. FAILLI, M. CIUFFI

2-Phenyl-pyrido[1,2-a]pyrimidin-4-one derivatives bearing a phenol or a catechol moiety in position 2 were tested as aldose reductase (ALR2) inhibitors and exhibited activity levels in the micromolar/submicromolar range. Introduction of a hydroxy gro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27da2ed585ca7a72f59c15482e9a7fd3
http://hdl.handle.net/11588/303940

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3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: Tricyclic Heteroaromatic Derivatives as a New Class of Benzodiazepine Receptor Ligands

Autor: Ettore Novellino, F. Da Settimo, Letizia Trincavelli, G. Primofiore, Anna Maria Marini, Giovanni Greco, Marco Gesi, Claudia Martini, Sabrina Taliani, C. La Motta

Publikováno v: Journal of Medicinal Chemistry. 43:96-102

A series of 3-substituted [1,2,4]triazino[4,3-c]benzimidazoles V were prepared and tested at the central benzodiazepine receptor (BzR). These compounds were designed as rigid analogues of the previously described N-benzylindolylglyoxylylamide derivat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e315588590d51d34b781e2287417e8c6
https://doi.org/10.1021/jm991131h

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N‘-Phenylindol-3-ylglyoxylohydrazide Derivatives: Synthesis, Structure−Activity Relationships, Molecular Modeling Studies, and Pharmacological Action on Brain Benzodiazepine Receptors

Autor: Antonio Da Settimo, Antonio Lucacchini, Giovanni Greco, Claudia Martini, Marco Gesi, G. Primofiore, Federico Da Settimo, and Gino Giannaccini, A. M. Marini, Ettore Novellino

Publikováno v: Journal of Medicinal Chemistry. 41:3821-3830

A series of N'-phenylindol-3-ylglyoxylohydrazides, isosters of the N-benzylindol-3-ylglyoxylamide derivatives previously described by us, were synthesized and tested for their ability to displace [3H]Ro 15-1788 from bovine brain membranes. These comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26c258d18c104775a66042b4a20970f
https://doi.org/10.1021/jm9800301

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Synthesis of pyrrolo[3,4-c]pyridine derivatives possessing an acid group and their in vitro and in vivo evaluation as aldose reductase inhibitors

Autor: Francesca Simorini, F. Da Settimo, A. Da Settimo, C. La Motta, G. Primofiore, E. Boldrini, Adriano Martinelli

Publikováno v: European Journal of Medicinal Chemistry. 31:49-58

Derivatives of [pyrrolo[3,4- c ]pyridin-1,3(2 H )-dion-2-yl] alkanoic acids were prepared and their in vitro aldose reductase inhibitory activity was tested on rat lens enzyme. The acetic derivatives 2, 5 and 15a–d proved to be much more potent inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2286b7a871d775b23fd0f72e0dca92d
https://doi.org/10.1016/s0223-5234(96)80006-7

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Isosteric replacement of the indole nucleus by benzothiophene and benzofuran in a series of indolylglyoxylylamine derivatives with partial agonist activity at the benzodiazepine receptor

Autor: F. Da Settimo, G. Senatore, Antonio Lucacchini, G. Primofiore, Anna Maria Marini, Claudia Martini, Sabrina Taliani

Publikováno v: European Journal of Medicinal Chemistry. 31:951-956

Summary A number of benzothienyl- and benzofurylglyoxylylamine derivatives, which are analogues of previously described indolylglyoxylylamines with a partial agonist activity, are reported in this paper. They were synthesized and tested to verify the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0c593e46f118f8a3cc27c70e2a1c8e
https://doi.org/10.1016/s0223-5234(97)86173-9

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ChemInform Abstract: Synthesis and Antihypertensive Activity of Some 2-Aminobenzimidazole and Indole Derivatives

Autor: Anna Maria Marini, G. Primofiore, A. Da Settimo, A. Subissi

Publikováno v: ChemInform. 22

The synthesis of some 2-aminobenzimidazole and indole amide derivatives containing a 2,6-dichloroaniline moiety is described. The preparation of a theophylline derivative is also reported. All the compounds tested showed no appreciable antihypertensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51c75615ee5f3da0fdfffd87f302f184
https://doi.org/10.1002/chin.199144170

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ChemInform Abstract: Benzodiazepine Receptor Affinity and Interaction of New Indole Derivatives

Autor: A. Da Settimo, Antonio Lucacchini, G. Senatore, F. Da Settimo, Claudia Martini, G. Primofiore

Publikováno v: ChemInform. 25

Recently, several derivatives, in which tryptamine, tyramine, and dopamine moieties are linked to the indole nucleus by an oxalyl bridge, were tested for their affinity and efficacy at the benzodiazepine receptor (BzR). To better define the structure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9fea85f1fc80518fe6e277ce1c389881
https://doi.org/10.1002/chin.199412312

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