Zobrazeno 1 - 10
of 10
pro vyhledávání: '"G. P. van der Schans"'
Reduced topoisomerase II activity in multidrug-resistant human non-small cell lung cancer cell lines
Autor:
Piet Borst, E. Kamst, A.J. Timmerman, G. P. Van Der Schans, M. De Haas, Frank Baas, E. W. H. M. Eijdems, G. C. B. Astaldi Ricotti, J. De Nooij
Publikováno v:
British Journal of Cancer
Scopus-Elsevier
British journal of cancer, 71(1), 40-47. Nature Publishing Group
Scopus-Elsevier
British journal of cancer, 71(1), 40-47. Nature Publishing Group
Multidrug-resistant (MDR) cell lines often have a compound phenotype, combining reduced drug accumulation with a decrease in topoisomerase II. We have analysed alterations in topoisomerase II in MDR derivatives of the human lung cancer cell line SW-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a687d539fd57d5042b4c96ac95c4b9
https://doi.org/10.1038/bjc.1995.9
https://doi.org/10.1038/bjc.1995.9
Publikováno v:
Journal of andrology. 21(2)
An immunochemical assay has been developed to detect oxidative damage in bovine sperm DNA. Sperm DNA contains a large amount of oxidative damage as a result of exposure to exogenous agents, but damage also can caused by normal metabolic processes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d81f4f852941cf1154ea1352273709e6
https://pubmed.ncbi.nlm.nih.gov/10714819
https://pubmed.ncbi.nlm.nih.gov/10714819
Autor:
A. G. Scheffer, Robert A. Baan, Roos H. Mars-Groenendijk, G. P. Van Der Schans, Hendrik P. Benschop, A. Fidder
Publikováno v:
Chemical research in toxicology. 7(3)
As part of a program to develop methods for dosimetry of exposure to sulfur mustard, we developed immunochemical methods for the detection of the major adduct, N7-[2-[(hydroxyethyl)thio]ethyl]guanine (N7-HETE-Gua), formed after alkylation of DNA with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8b1d44280cca80a71b19adf430ca0f
https://pubmed.ncbi.nlm.nih.gov/8075373
https://pubmed.ncbi.nlm.nih.gov/8075373
Autor:
G. P. Van Der Schans, Hendrik P. Benschop, A. G. Scheffer, Robert A. Baan, G. W. H. Moes, A. Fidder, L.P.A. de Jong
Publikováno v:
Chemical research in toxicology. 7(2)
As part of a program to develop methods for verification of alleged exposure to sulfur mustard, we synthesized and characterized the adducts most likely formed by alkylation of DNA with sulfur mustard: N7-[2-[(2-hydroxyethyl)thio]ethyl]guanine (1), b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1606343790f5cba4ce7567abbdc281
https://pubmed.ncbi.nlm.nih.gov/8199309
https://pubmed.ncbi.nlm.nih.gov/8199309
Publikováno v:
Radiation research. 131(3)
The XR-V9B mutant of Chinese hamster V79 cells which exhibits hypersensitivity to ionizing radiation was isolated by the replica plating technique. The increased sensitivity of XR-V9B cells to X rays (approximately 4-fold, as judged by the D10) was a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d2743096759b6483d3ec31b517e9649d
https://pubmed.ncbi.nlm.nih.gov/1438689
https://pubmed.ncbi.nlm.nih.gov/1438689
Autor:
G. P. van der Schans
Publikováno v:
The Early Effects of Radiation on DNA ISBN: 9783642751509
In research on the modification by chemical agents of the effects of ionizing radiation, most attention has been directed towards application of radiosensitizing or radioprotective drugs in cancer radiotherapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8bb396aab928e5b2fea0384edfd0a8f
https://doi.org/10.1007/978-3-642-75148-6_36
https://doi.org/10.1007/978-3-642-75148-6_36
Publikováno v:
Radiation Research. 131:309
The XR-V9B mutant of Chinese hamster V79 cells which exhibits hypersensitivity to ionizing radiation was isolated by the replica plating technique. The increased sensitivity of XR-V9B cells to X rays (approximately 4-fold, as judged by the D10) was a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdd4ff2e4623a28f368a50e7f09f17f8
https://doi.org/10.2307/3578421
https://doi.org/10.2307/3578421
Publikováno v:
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f641b76ee200a45747cc8839993fdad7
https://pubmed.ncbi.nlm.nih.gov/2673152
https://pubmed.ncbi.nlm.nih.gov/2673152
Publikováno v:
Archives of Toxicology ISBN: 9783540503361
In recent years, knowledge about the regulation of cellular growth has expanded tremendously. An important element in the research on this topic has been the demonstration that genes involved in cell proliferation, whether of normally regulated cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6dabdfc4c4be12ac8ad93a742534be0
https://doi.org/10.1007/978-3-642-74117-3_7
https://doi.org/10.1007/978-3-642-74117-3_7
Publikováno v:
Cancer research. 49(6)
We have isolated three radiosensitive mutants (V-C4, V-E5, and V-G8) of the Chinese hamster V79 cell line which also show increased sensitivities to killing by bleomycin (approximately 2-5-fold) and ethyl methanesulfonate (approximately 2-fold). Gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::57afb1c3f4a324fbc1e96ef25eccc602
https://pubmed.ncbi.nlm.nih.gov/2466555
https://pubmed.ncbi.nlm.nih.gov/2466555