Zobrazeno 1 - 10
of 18
pro vyhledávání: '"G. P. Tosolini"'
Publikováno v:
European Journal of Clinical Pharmacology. 10:257-262
In a pharmacokinetic study of the new analgesic and anti-inflammatory drug indoprofen, plasma levels and urinary excretion were determined in four healthy volunteers after 100 mg and 200 mg iv, and after 100 mg (capsules) and 200 mg (tablets) oral do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6be115c9fee502196b2c55af16c4408
https://doi.org/10.1007/bf00558338
https://doi.org/10.1007/bf00558338
Publikováno v:
European Journal of Clinical Pharmacology. 15:323-327
Six healthy volunteers received single iv and oral doses of 2-[p-(1-oxo-2-isoindolinyl)phenyl] butyric acid 100 mg (indobufen; K 3920), an inhibitor of platelet aggregation. Plasma levels and urinary excretion of the drug were determined by GLC. Coll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1fa19b0fd72ff61302201e52a012da2
https://doi.org/10.1007/bf00558435
https://doi.org/10.1007/bf00558435
Publikováno v:
European Journal of Clinical Pharmacology. 6:256-260
The fate of the new analgesic and anti-inflammatory agent α-[4-(1-oxo-2-iso-indolinyl)-phenyl]-propionic acid (compound K 4277) in healthy volunteers has been investigated by a radio-isotope method and gas-liquid chromatography. After oral administr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77747ab168b7c362b148652c60557110
https://doi.org/10.1007/bf00644742
https://doi.org/10.1007/bf00644742
Autor:
Giuliano Nannini, Longo R, I. De Carneri, G. Meinardi, G. P. Tosolini, Pier Nicola Giraldi, E. Dradi, Gisella Monti
Publikováno v:
Biochemical Pharmacology. 20:339-349
The metabolism has been investigated in man of 1-( N - β -ethylmorpholine)-5-nitroimidazole, a new trichomonacidal agent. From the urine of patients treated with the compound, two main metabolites have been isolated, quantitatively determined and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9116141eaa1e0f344d22c0e70000523
https://doi.org/10.1016/0006-2952(71)90068-2
https://doi.org/10.1016/0006-2952(71)90068-2
Publikováno v:
Journal of Heterocyclic Chemistry. 7:1429-1431
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::268aa419f2953f7663ef3228d74b80df
https://doi.org/10.1002/jhet.5570070636
https://doi.org/10.1002/jhet.5570070636
Publikováno v:
Arzneimittel-Forschung. 24(10)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e602b8d4479ac6ccac9301a342fe163e
https://pubmed.ncbi.nlm.nih.gov/4479769
https://pubmed.ncbi.nlm.nih.gov/4479769
Publikováno v:
International journal of clinical pharmacology and biopharmacy. 15(8)
The influence of food on the bioavailability of two oral dosage forms (100-mg capsules and 200-mg tablets) of indoprofen, a new propionic acid derivative with marked anti-inflammatory and analgesic properties, has been investigated. Plasma levels and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16b33b17925a63dd30283200e2d38d27
https://pubmed.ncbi.nlm.nih.gov/302241
https://pubmed.ncbi.nlm.nih.gov/302241
Publikováno v:
Thrombosis and Haemostasis.
Given by the i.v. route to healthy volunteers, indobufen has an half-life of 7-9 h. After oral administration of tablets, the drug is completely absorbed. Excretion occurs through the kidney and the drug is present in the urine as glucoronide and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73c36ab2eb6536ed0e2efa6d89a23007
https://doi.org/10.1055/s-0039-1684449
https://doi.org/10.1055/s-0039-1684449
Publikováno v:
European journal of clinical pharmacology. 15(5)
The effect of food on bioavailability of indobufen tablets was investigated in 6 healthy volunteers. Subsequently, the same subjects took 100 mg b.i.d. for 7 days. Plasma levels and urinary excretion of indobufen were determined by GLC. Platelet aggr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e19f17350b9c234324ecd04c39fc15
https://pubmed.ncbi.nlm.nih.gov/456404
https://pubmed.ncbi.nlm.nih.gov/456404
Publikováno v:
International journal of clinical pharmacology and biopharmacy. 15(9)
The pharmacokinetics of indoprofen in healthy subjects after single oral and i.v. administrations is reviewed. During repeated administration of indoprofen to 6 normal subjects (200-mg tablet every 8 hours for 6 days) no variations in the disposition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::55613730641f98ee2ffc6673b6a6ae0c
https://pubmed.ncbi.nlm.nih.gov/303237
https://pubmed.ncbi.nlm.nih.gov/303237