Výsledky vyhledávání - "G. P. Sergeant"

A seminal study on the mechanisms underlying spontaneous activity of the seminal vesicles?

Autor: M A, Hollywood, K D, Thornbury, G P, Sergeant

The mucosa may have neuron‐like functions as urinary bladder mucosa releases bioactive substances that modulate sensory nerve activity as well as detrusor muscle contractility. However, such mucosal function in other visceral organs remains to be e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b241207189a9e31d7a0fca7fb09be62d
https://europepmc.org/articles/PMC5509879/

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Royal Academy of Medicine in Ireland Section of Biomedical Sciences

Autor: C. G. Gallagher, J. G. Noble, L. A. J. O’Neill, G. Boland, M. Quinn, M. A. Hollywood, I. D. Hill, C. Sweeney, C. M. O’Connor, B. F. Leek, M. D. Walker, R. G. O’Regan, D. C. Moriarty, A. J. Mackarel, S. O’Connor, K. M. O’Boyle, A. Moore, B. A. Gormley, A. McGuigan, J. J. O’Connor, P. McLoughlin, G. Saleshando, T. Robson, F. M. Keane, N. G. McHale, C. S. Downes, C. E. Herron, C. R. Barnett, H. R. Harty, S. R. McKeown, S. Ryan, S. M. McDonough, A. E. Dusoir, C. N. Scholfield, G. O’Cuinn, E. O’Loinsigh, E. M. Dunne, D. M. Cannon, M. McGuire, K. M. Lagan, S. D. Moore, D. M. Walsh, A. F. L. Cramp, W. T. McNicholas, A. S. Lowe, P. P. Corkery, K. D. McCloskey, J. M. Allen, P. D. Glasgow, D. Cox, C. Hutchinson, D. G. Hirst, T. Quinn, P. Nolan, E. Kilbride, G. McBean, A. K. Keenan, T. M. Curtis, V. C. Cullen, D. A. Hurley, S. Wilson, C. R. Clarke, G. D. Baxter, D. Hirst, H. P. Frizelle, A. Bradford, J. P. Ryan, B. P. Curran, S. W. Kerrigan, A. W. Baird, B. M. Hannigan, O. Carroll, D. J. Fitzerald, K. D. Thornbury, P. J. Magee, G. P. Sergeant, R. Humphrey

Publikováno v: Irish Journal of Medical Science. 168:286-297

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f611db24e64866b1046267ac4433f69a
https://doi.org/10.1007/bf02944360

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Investigation of L-type Ca(2+) current in the aganglionic bowel segment in Hirschsprung's disease

Autor: R J, Large, E, Bradley, T, Webb, A M, O'Donnell, P, Puri, M A, Hollywood, K D, Thornbury, N G, McHale, G P, Sergeant

Publikováno v: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 24(12)

Studies on animal models of Hirschsprung's disease (HD) suggest that L-type Ca(2+) channels are down-regulated in the aganglionic bowel segment, however, this has yet to be confirmed in HD patients. The objective of this study was to test the hypothe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e4fc8b0b9c05195688448a12caa19f22
https://pubmed.ncbi.nlm.nih.gov/22947173

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Pharmacological and molecular evidence for the involvement of Kv4.3 in ultra-fast activating K+ currents in murine portal vein myocytes

Autor: S Y M, Yeung, S, Ohya, G P, Sergeant, V, Pucovský, I A, Greenwood

Publikováno v: British journal of pharmacology. 149(6)

The aim of this study was to determine the molecular identity of a transient K+ current (termed IUF) in mouse portal vein myocytes using pharmacological and molecular tools.Whole cell currents were recorded using the ruptured patch con from either ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e0df5696fec2d192d894ab679a2b66f9
https://pubmed.ncbi.nlm.nih.gov/17016508

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Activation of the cGMP/PKG pathway inhibits electrical activity in rabbit urethral interstitial cells of Cajal by reducing the spatial spread of Ca2+ waves

Autor: G P, Sergeant, Louise, Johnston, N G, McHale, K D, Thornbury, M A, Hollywood

Publikováno v: The Journal of physiology. 574(Pt 1)

In the present study we used a combination of patch clamping and fast confocal Ca2+ imaging to examine the effects of activators of the nitric oxide (NO)/cGMP pathway on pacemaker activity in freshly dispersed ICC from the rabbit urethra, using the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3854353e23bccbcfb5aaecb3740e5778
https://pubmed.ncbi.nlm.nih.gov/16644801

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Calcium oscillations in interstitial cells of the rabbit urethra

Autor: L, Johnston, G P, Sergeant, M A, Hollywood, K D, Thornbury, N G, McHale

Publikováno v: The Journal of physiology. 565(Pt 2)

Measurements were made (using fast confocal microscopy) of intracellular Ca2+ levels in fluo-4 loaded interstitial cells isolated from the rabbit urethra. These cells exhibited regular Ca2+ oscillations which were associated with spontaneous transien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::642484a58cc67403fc0dce5ca1fedfc5
https://pubmed.ncbi.nlm.nih.gov/15760947

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Modulation of spontaneous Ca2+-activated Cl- currents in the rabbit corpus cavernosum by the nitric oxide-cGMP pathway

Autor: M, Craven, G P, Sergeant, M A, Hollywood, N G, McHale, K D, Thornbury

Publikováno v: The Journal of physiology. 556(Pt 2)

The whole-cell perforated patch clamp technique was used to study membrane currents in isolated rabbit corpus cavernosum smooth muscle cells. Depolarization from -80 mV to the range -40 to -10 mV evoked a nifedipine-sensitive Ca(2+) current that was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::476a08323e8a309fffe1a2db2b283bbe
https://pubmed.ncbi.nlm.nih.gov/14766939

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TREK-1 regulation by nitric oxide and cGMP-dependent protein kinase. An essential role in smooth muscle inhibitory neurotransmission

Autor: S D, Koh, K, Monaghan, G P, Sergeant, S, Ro, R L, Walker, K M, Sanders, B, Horowitz

Publikováno v: The Journal of biological chemistry. 276(47)

Potassium channels activated by membrane stretch may contribute to maintenance of relaxation of smooth muscle cells in visceral hollow organs. Previous work has identified K(+) channels in murine colon that are activated by stretch and further regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f820eedf26ac88cbfea5bede869809e7
https://pubmed.ncbi.nlm.nih.gov/11560940

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Spontaneous Ca2+ activated Cl- currents in isolated urethral smooth muscle cells

Autor: G P, Sergeant, M A, Hollywood, N G, McHale, K D, Thornbury

Publikováno v: The Journal of urology. 166(3)

We identified and characterized the membrane currents underlying spontaneous transient depolarization in the urethra.Myocytes were isolated from sheep urethra by enzymatic digestion and studied by the amphotericin B patch clamp method.Just more than

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2bbf3c520e763849455ba34637f73856
https://pubmed.ncbi.nlm.nih.gov/11490316

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