Výsledky vyhledávání - "G. P. O'neill"

Akademický článek

Graphene-based nanocomposites for gas sensors: challenges and opportunities.

Autor: Banglani, Talib Hussain¹ (AUTHOR), Chandio, Imamdin² (AUTHOR), Khilji, Meher-Un-Nisa¹ (AUTHOR), Ibrar, Aliya³ (AUTHOR), Memon, Ayaz Ali¹ (AUTHOR) ayazmemon33@usindh.edu.pk, Ali, Ayaz^4,5 (AUTHOR), Al-Anzi, Bader S.⁶ (AUTHOR), Thebo, Khalid Hussain⁷ (AUTHOR) Khalidthebo@yahoo.com

Publikováno v: Reviews in Inorganic Chemistry. Sep2024, Vol. 44 Issue 3, p385-408. 24p.

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Expression of the Synechocystis sp. strain PCC 6803 tRNA(Glu) gene provides tRNA for protein and chlorophyll biosynthesis

Autor: Dieter Söll, G P O'Neill

Publikováno v: Journal of Bacteriology. 172:6363-6371

In the cyanobacterium Synechocystis sp. strain PCC 6803 (Synechocystis 6803) delta-aminolevulinic acid (ALA), the sole precursor for the synthesis of the porphyrin rings of heme and chlorophyll, is formed from glutamate activated by acylation to tRNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c81247dee5eab20e9a490d0a957bdc
https://doi.org/10.1128/jb.172.11.6363-6371.1990

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Akademický článek

Potential of extracellular vesicles in the pathogenesis, diagnosis and therapy for parasitic diseases.

Autor: Pinheiro, Ana Acacia Sá^1,2 (AUTHOR), Torrecilhas, Ana Claudia³ (AUTHOR), Souza, Bruno Solano de Freitas^4,5 (AUTHOR), Cruz, Fernanda Ferreira^1,2 (AUTHOR), Guedes, Herbert Leonel de Matos^6,7 (AUTHOR), Ramos, Tadeu Diniz^6,7 (AUTHOR), Lopes‐Pacheco, Miqueias^1,8 (AUTHOR), Caruso‐Neves, Celso^1,2,9 (AUTHOR), Rocco, Patricia R. M.^1,2,9 (AUTHOR) prmrocco@gmail.com

Publikováno v: Journal of Extracellular Vesicles. Aug2024, Vol. 13 Issue 8, p1-24. 24p.

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Purification of the glutamyl-tRNA reductase from Chlamydomonas reinhardtii involved in delta-aminolevulinic acid formation during chlorophyll biosynthesis

Autor: Min-Wei Chen, Dieter Jahn, G P O'Neill, Dieter Söll

Publikováno v: Journal of Biological Chemistry. 265:4058-4063

The formation of delta-aminolevulinic acid, the first committed precursor in porphyrin biosynthesis, occurs in certain bacteria and in the chloroplasts of plants and algae in a three-step, tRNA-dependent transformation of glutamate. Glutamyl-tRNA red

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3cb6760f242e108e0855c4800009896d
https://doi.org/10.1016/s0021-9258(19)39702-9

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The anticonvulsant, antihyperalgesic agent gabapentin is an agonist at brain gamma-aminobutyric acid type B receptors negatively coupled to voltage-dependent calcium channels

Autor: S, Bertrand, G Y, Ng, M G, Purisai, S E, Wolfe, M W, Severidt, D, Nouel, R, Robitaille, M J, Low, G P, O'Neill, K, Metters, J C, Lacaille, B M, Chronwall, S J, Morris

Publikováno v: The Journal of pharmacology and experimental therapeutics. 298(1)

Gabapentin (Neurontin, Pfizer Global RD) is a novel anticonvulsant, antihyperalgesic, and antinociceptive agent with a poorly understood mechanism of action. In this study, we show that gabapentin (EC50 2 microM) inhibited up to 70 to 80% of the tota

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::775354e315e9c7bd306beeb71f8e1704
https://pubmed.ncbi.nlm.nih.gov/11408520

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Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action

Autor: G Y, Ng, S, Bertrand, R, Sullivan, N, Ethier, J, Wang, J, Yergey, M, Belley, L, Trimble, K, Bateman, L, Alder, A, Smith, R, McKernan, K, Metters, G P, O'Neill, J C, Lacaille, T E, Hébert

Publikováno v: Molecular pharmacology. 59(1)

Gamma-aminobutyric acid (GABA) activates two qualitatively different inhibitory mechanisms through ionotropic GABA(A) multisubunit chloride channel receptors and metabotropic GABA(B) G protein-coupled receptors. Evidence suggests that pharmacological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::39acdf387f79553b1e8479d24874c875
https://pubmed.ncbi.nlm.nih.gov/11125035

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Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor

Autor: R, Sullivan, A, Chateauneuf, N, Coulombe, L F, Kolakowski, M P, Johnson, T E, Hebert, N, Ethier, M, Belley, K, Metters, M, Abramovitz, G P, O'Neill, G Y, Ng

Publikováno v: The Journal of pharmacology and experimental therapeutics. 293(2)

Direct evidence is lacking to show whether the gamma-aminobutyric acid (GABA)(B) gb1-gb2 heterodimer is the signaling form of the receptor. In this study, we tested whether gb1a or gb2 subunits when coexpressed with truncated receptors or metabotropi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b5c2c993746f2248c300bb10e072980e
https://pubmed.ncbi.nlm.nih.gov/10773016

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Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles

Publikováno v: The Journal of pharmacology and experimental therapeutics. 290(2)

The discoveries that cyclooxygenase (COX)-2 is an inducible form of COX involved in inflammation and that COX-1 is the major isoform responsible for the production of prostaglandins (PGs) in the gastrointestinal tract have provided a rationale for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::894a118b5cd5d38dfcabb49a665a15c7
https://pubmed.ncbi.nlm.nih.gov/10411562

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